80
The vaccine for prevention of echinococcosis of animals.
M. Aminjonov*, Sh. Rasulov, Sh.U. Aminjonov.
Research Institute of Veterinary after named acad. K.I. Skryabin, Samarkand, Uzbekistan.
The results of the experiment indicated that the vaccine prepared from cultural production protoskolexes of
echinococcus cysts possessed with high immunogenic activity. As it is found from the results of the experiment
its efficiency was from 50.0% to 100.0% depending from the doze. In the laboratory conditions the efficiency
of tested vaccine doze reached - 80% (table 1). In the immunized sheep the number and size of cysts were in
3-4 times lower in comparison with control one. As always, the number of dead cysts in the experimental sheep
was higher in comparison with control animals. For example in the first variant from 50 cysts 42 appeared dead
(85.0%) or at the second variant from 70 cysts - 66 specimens were (94.3%) petrificated. The same results were
obtained from the used doze of vaccine at the third and the fourth variants of experiments. Particularly from
the 16 cysts at the third variant -12 cysts were dead (80.0%); from 23 cysts of control sheep only 5 were dead
(21.7%), At the fourth variant the vaccine efficiency was 50.0-80.0%. But the number of died cysts in
experimental groups was much higher than in controle sheep. In the production conditions a good results were
obtained from vaccine usage. From 10 thousands of immunized wether lambs only 23 were infested by
echinococcosis (0.23%). The studied vaccine had rather immunogenic effect concerning the prophylaxis of
dog’s echinococcosis. The efficiency of vaccine depending from the used doze reached 100%. The number of
found echinococcus was in 5-6 times less in comparison with control dogs. The level of immunizing feature of
the vaccine increases gradually. That’s why in artificially infested animals, the large number of echinococcus
eggs was inoculated in sheep organism, but their considerable quantity with the increasing immunity titer began
petrificated not reaching their full development. Such phenomena was not observed in controle sheep. The
vaccine may be used for the echinococcosis prophylaxis in dogs. The results of the experiments on dogs showed
that echinococcus in dog’s intestine were located not on the surface but deeper in the inner mucous and
mascular covers. Taking into consideration this, we can say that dog’s echinococcus refers to the tissue
helminthes and differs from multicepts. Consequently, the immunity formation in dogs is a natural phenomena
and besides the existing methods in the struggle with dog’s echinococcosis the immunoprophylaxis is
recommended. The vaccination of dogs against echinococcosis is the most reliable and effective method in the
spreading of echinococcosis among productive animals and people.
Imidacloprid + moxidectin topical solution as a monthly treatment for prevention of heartworm
infection
(Dirofilaria immitis)
and control of fleas
(Ctenocephalides felis
) on cats.
R.G. Arther
a
*, D.D. Bowman
b
, J.W. McCall
0
, O. Hansen
d
, D.R. Young
e
.
“Bayer Healthcare, Shawnee Mission, Kansas, USA;
b
CHK, Stanwood, Michigan, USA;
C
TRS Athens, Georgia, USA;
d
Bayer AG,
Monheim, Germany; “YVRS, Turlock, California, USA.
Imidacloprid applied monthly as a low volume topical application to cats provides highly effective flea control.
Fleas are immobilized and killed after contact with imidacloprid on the dermis or hair of cats. Moxidectin is
100 % efficacious against preadult heartworm stages in dogs when administered orally or parentally in various
formulations. Studies were conducted to evaluate flea control and heartworm prevention in cats with topically
applied moxidectin and imidacloprid formulations. Moxidectin applied topically (1 mg/kg) was 100 %
efficacious against experimental pre adult
D. immitis
infections. Moxidectin solution alone had little or no
activity against adult fleas
(C.felis).
Imidacloprid alone (10 mg /kg) had no activity against preadult stages of
D. immitis.
Monthly topical treatment of cats with a combined formulation to provide 10 mg/kg imidacloprid
+ 1 mg/kg moxidectin provided 100 % prevention of D. immitis infection and >96 % control of adult fleas.
