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METHODS OF PREVENTION AND
TREATMENT OF TRICHOPHYTE IN CAUSE
(literature analysis)
Usmanova Khadicha Juraevna
–
doctoral student.
https://orcid.org/0009-0005-6103-7389
Veterinary Research Institute
Abstract
: Effective treatment of trichophytosis in cattle with the effective use of systemic
drugs. To do this, the animals infected with trichophytia should be divided into groups, each
drug should be used and monitored every ten days. Early treatment is based on the results
obtained. It consists of taking skin and wool samples from the recovered part of the disease in
laboratory conditions, planting them in food, making differential diagnosis in other similar
diseases, and studying the effects of the used drugs. Treatment in this way is to increase the
productivity of farm animals and reduce the rate of transmission to humans. In addition to
these, lecoformulation by taking blood samples from animals that have recovered from the
disease. In this, the shaped elements of the blood are checked. The obtained results and each
systemic drug used are formed on the basis of the scheme and entered in tabular form.
Annatatsiya
: Qoramollar trixofitiya kasalligini davolashda tizimli preparatlardan unumli
foydalangan holda davolashni samarali amalga oshirish. Buning uchun trixofitiya bilan
kasallangan hayvonlarni guruhlarga bo‘lgan holda har bir preparatlarni qo‘llab, har o‘n kunda
kuzatib borishdan iborat. Olingan natijalarga qarab davolashni erta amalga oshirishdir.
Laboratoriya sharoitida kasallikdan tuzalgan qismidan teri va jun namunalari olinib oziq-
muhitlarga ekib ko‘rish va boshqa o‘xshash kasalliklarda diferentsial diagnostika qilib,
qo‘llanilgan preparatlar ta’sitini o‘rganishdan iborat bo‘ladi. Bu usulda davolash qishloq
xo‘jalik hayvonlarni maxsuldorligini oshirish hamda odamlarga yuqish tezligini
kamaytirishdan iboratdir. Bulardan tashqari kasallikdan tuzalgan hayvonlardan qon namunalari
olinib lekoformula qilish. Bunda qonning shaklli elementlari tekshiriladi. Olingan natijalar va
qo‘llanilgan har bir tizimli preparatlar sxema asosida shakllantirilib, jadval ko‘rinishda kiritish.
Key words
: cattle, ectoparasites, dermatitis, trichophytia, ivermectin, multivitamin, LTF-130
vaccine, tetramak, flukonozol, butamine drugs are under research.
Kalit so‘zlar
: qoramol, ektoparazitlar, dermatit, trixofitiya, ivermektin, multivitamin, LTF-130
vaktsina, tetramak, flukonozol, butamin kabi preparatlar tadqiqotlarda.
Introduction
: Cattle diseases caused by ectoparasites are widespread in mountain and sub-
mountain regions. Ectoparasites cause inflammation of the skin and other organs, which leads
to discomfort, mechanical damage in the process of scratching, and a decrease in meat and milk
products in cattle. For decades, chlorine, organophosphorus and carbamate drugs have been
used in the fight against diseases of invasive origin. It should be noted that most of them do not
Western European Journal of Modern Experiments
and Scientific Methods
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meet modern requirements due to their ineffectiveness, high toxicity for animals and humans,
long-term accumulation and storage in the external environment and animal div.
Due to the unfavorable epidemiological and social situation in different countries of the world,
the distribution, etiology, clinical course and treatment of zooanthropon dermatomycosis,
including trichophytosis, remain the focus of attention of both dermatovenerologists and health
leaders [1,2;33b]
Despite the availability of many modern external and systemic pharmacological agents, their
therapeutic effectiveness remains rather low, so the problem of treating dermatomycosis is
relevant not only for veterinary medicine, but also for medicine [3,4,5,7,6,9,7]. .
It should be noted that vaccines against dermatophytosis (Vakderm, Poli-vac-TM, Microderm,
etc.) are recommended for use in pets from 1-1.5 months of age. However, because the immune
system is not well developed in newborn animals, they are very sensitive to pathogens and
suffer from dermatomycosis, sometimes in severe form. [5,6;61-62,]
Many methods of treating trichophytosis in animals are known, including the use of used motor
oil with up to 70% aromatic hydrocarbons, 10% water, traces of ferrous iron, chlorine, nitrogen
and sulfur; mixtures of acetic acid with sulfur and diesel oil, 85% hexamide paste, 0.25%
trichocetin suspension in fish oil or petroleum jelly, 3% aminophosphonic oil, juglone, 10-20%
sulfuric acid, 10% sulfur and 3% salicylic mixture 10% sulfur tar ointments, lamisil, mycospor,
clotriazole, etc.
For the treatment and prevention of trichophytosis, LTF-130 vaccines and drugs in the form of
ointments or liniments are often used. The main antimycotic used in the treatment of
trichophytosis is griseofulvin, the daily dose of which is equal to 18-25 mg / kg of div weight.
Griseofulvin is taken daily until the first negative test, then daily for 2 weeks, then 2 more
weeks at 3-day intervals. Griseofulvin is poorly soluble in water and causes side effects in the
form of dyspeptic symptoms and urticaria [Malanin L.P., Morozov A.P., Selivanova A.S
1988].[6,7,8,9; 278-278-100-101].
In trichophytosis, acaricides from the ivermectin group were used for preventive and
therapeutic purposes.
In production conditions, we used systemic drugs: systemic drugs - ivermectin and
multivitamin, LTF-130 vaccine and tetramak, fluconazole and butamine, which had a good
therapeutic effect in the treatment of a large number of small cattle in autumn and winter. Blood
is a liquid medium of the div, through which organs, tissues and cells are filled with all
nutrients and oxygen, as well as metabolic products are removed. A change in the
morphological composition of blood is an indicator of metabolic diseases in the animal div.
The purpose of the study: The purpose of our study was to study the clinical condition of the
animal organism, the effect of these drugs before and after the treatment of trichophytosis in
cattle.
Materials and methods. The experiment was conducted on 4-5-month-old calves with moderate
obesity and live weight of 112-130 kg. Experimental animals were divided into four groups:
three experimental and one control, each with four heads. Before the experiment, wool and
affected skin samples were taken from all group animals for the study. The first experimental
group: animals were injected with LTF 130 vaccine 5.0 ml, tetramak 5.0 ml into the thigh
muscles, the second experimental group: ivermectin was injected subcutaneously into the
forearm in a dose of 5.0 ml, multivitamin 5.0 ml into the thigh muscle. The third experimental
Western European Journal of Modern Experiments
and Scientific Methods
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ISSN (E): 2942-1896 Open Access| Peer Reviewed
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group: a mixture of fluconazole 150 ml and butamine drug 5.0 ml, a total of 155 ml, was
injected into the jugular vein. Control group animals remained for the experiment.
Table 1
Scheme of treatment of calves infected with trichophytosis
Results and their analysis. In the course of research, the diameter of the injured skin formation
stopped expanding, and small hairs began to grow around it. At the end of the experiment, this
part was covered with wool. From covered wool and skin, 5-6 hairs and 1 cm of skin products
were taken to the laboratory for examination and checked for the presence of fungus.
Results: During the research, fungi were found at all stages of the development of the skin
derivative before the experiment. In the animals of the first, second and third experimental
groups, already on the 10th day, the signs of dermatitis were alleviated, itching was almost not
felt. In 20 days, wounds disappear in experimental animals, the hairline is not tangled. tr.
verrucosum was not found when the skin was scraped and microscopically examined on days
10-20 of the experimental group animals. The animals in the control group showed clinical
signs of dermatitis in all periods of the study.
The scores increased slightly in the control group, but significantly higher than in the
experimental group. The study of the distribution of fungi and age dynamics in cattle showed
that in the autumn-winter period, young animals under one year of age are most often infected
with trichophyta. The invasion of ectoparasites in the conditions of private households is not
so clear.
Conclusion: Studies have shown that systemic drugs - ivermectin and multivitamin, LTF-130
vaccine and tetramac, fluconazole and butamine have a therapeutic effect on cattle
trichophytosis at tested doses. A decrease in the number of erythrocytes and hemoglobin was
found in the study of hematological parameters in trichophytosis of cattle, which may indicate
a decrease in the supply of oxygen and nutrients to the tissues and organs of the animal div
with dermatitis of parasitic etiology. In experimental animals, the rate of wool production in
the skin derivative changes slightly after 9 days, and after 20 days they cover the skin. After
30 days, the animals will fully recover.
Groups
Number
of heads
Methods of treatment
Treatme
nt
effective
ness
Name of the
drug
Injection
method
The
amount
of
the
drug
Follow-
up
period,
days
The cost of
1 calf, sum
I experiment
4
LTF-130
vaccine
+
tetramag
Muscle
10,0 ml
5,0 ml
9-20
25000
100%
II experiment
4
Ivermectin
+
multivitami
n
Under
the skin
3-ml
20
11000
100%
Muscle
5-ml
III experiment
4
Fluconazole
+ butamine
blood
vessel
150-ml -
5 ml
20
18000
100%
IV control
4
the drug is
not used
-
-
30
-
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