2023WCAC I 2023WPC
2023WNPC & 2023WHCS, September 08-09, 2023
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It emphasizes the importance of careful monitoring for adverse drug reactions in pediatric patients who are receiving these
medications.
Keyword: Steve ns-J oh n son syndrome (SJS), Leukopenia and Thrombocytopenia, Lamotrigine in Combination with Valproic Acid.
Gait Disturbance Patient with Hydrocephalus Due to CMV Encephalitis
Jae Hyun JEON, Min Kim, Young Hee Sung
’Department of Neurology, Gil Medical Center, Gachon University College of Medicine, Incheon, South Korea
Background and Purpose: CMV encephalitis can present in various ways and may be asymptomatic or show symptoms like confusion,
cognitive decline, and focal neurologic abnormalities. In this case study, we report a rare manifestation of CMV infection ca using
hydrocephalus due to ventriculoencephalitis.
Case: A 71-year-old female presented to the emergency room with gait disturbance, headache, frequent urination, and cognitive
dysfunction 5 days after receiving the second dose of Astrazeneca vaccine. She had an acute-looking appearance with a fever of
38“C, but no prominent meningeal irritation signs. Her neurological exam showed drowsiness, disorientation, and weak muscle
strength. Her laboratory findings did not show any definite inflammation or infections. Brain CT showed increased ventricle s ize and
hypoattenuation in the corpus callosum and periventricular region, indicating hydrocephalus. Lumbar puncture showed clear
cerebrospinal fluid (CSF) with elevated lymphocytes and mildly raised protein. Initially, tuberculosis meningoencephalitis was
suspected, but after starting ТВ medication and high-dose dexamethasone, the patient's symptoms worsened, and EVD was
reinserted. A few CSF tests showed CMV infection, and the patient was started on intravenous ganciclovir. After two weeks, she
received ventriculoperitoneal shunt operation and is currently monitoring the progress while controlling the VP shunt pressure.
Conclusion: CMV encephalitis is rare and usually occurs in immunocompromised patients, such as those with HIV/AIDS. In this case,
the patient's immunosuppressive state due to medical illness, poor condition after vaccination, and the use of high-dose
dexamethasone may have led to CMV reactivation. Clinicians should consider CMV infection as a potential cause of hydrocephalus
in patients with neurological symptoms, even without typical signs of inflammation or infections.
Clinical Manifestations of Post-Covid Syndrome among Children
Gulchekhra Khamraeva
1
, Iroda Shaxizirova
2
’Department of Anesthesiology and Intensive Care in Pediatrics, Center for the development of professional skills of medical staff
under the Ministry of Health of the RUz, Tashkent, Uzbekistan
^Department of Pediatrics, Center for the development of professional skills of medical staff under the Ministry of Health of the RUz,
Tashkent, Uzbekistan
Relevance: Studies conducted in the USA, Great Britain, Sweden (observations of more than 4 million people) revealed a variety of
complaints and symptoms among patients after an acute periodof COVID-19. Therefore, the concept of "post-
covid syndrome” (PCS)
appeared. In the domestic andforeign literature, there are few data on the study of PCS among children and adolescents, and an
intensive analysis of the obtained clinical observations is currently being carried out. The symptoms of PCS are polymorphic. Timely
examination with differential diagnosis will allow not only to make a diagnosis, but also to recommend therapy with a personalized
approach to the correction of PCS.
Aim of the study: To study the features of the course of post-covid syndrome among children. Materials and methodology: 253 children
who had had covid infection during the previous 6 months were examined. The age of patients was from 1 to 17 years. This group of
patients was examined by an allergist-immunologist, a cardiologist, a neurologist, a gastroenterologist, a pediatrician.
Results of the study: according to the results of the study, it was revealed that 177 children had post- covid syndrome, which accounted
for 69.96%, of which 30.5% (54 children) of children had a loss of div weight of more than 10%, 25.4% (45 children) had conjunctivitis
, 50.3% (89 children) had fatigue and weakness, 40.1% (71 children) of the examined had frequent acute respiratory viral infections,
tonsillitis, skin rashes in 30.5% (54 children) of the examined. 40.1% of children, frequent acute respiratory viral infections and tonsillitis
are observed over the next 6 months, even if the infection is asymptomatic. According to the results of the study, sleep disorders were
noted in 60.5%, headaches in 25.4% of the examined children with post-covid syndrome, dizziness in 30.5% of children. All examined
children with post-covid syndrome showed changes in the general blood test: leukopenia in 20%, lymphopenia in 50%, elevated ESR
in 80%, and a decrease in platelets in 60% of children. Echocardiography changes were found in 40% of the examined children:
blockade of the legs and bundles of His, arrhythmias (extrasystole), ST-segment elevation, in 10% of the changes in the CT of the
lungs: residual effects of pneumonia, in 15% of the changes in the ultrasound of the abdominal cavity: enlarged liver, mesenteric
lymphadenopathy.
Conclusion: post-covid syndrome is characterized by frequent acute respiratory viral infections and tonsillitis in the next 6 months,
fatigue and weakness, sleep disturbances. In instrumental studies, there are arrhythmias, blockade on echocardiography, residual
effects of pneumonia on CT scan of the lungs, liver enlargement and mesenteric lymphadenopathy on ultrasound of the abdominal
cavity.
Biography: Dr. Khamraeva -DcS, Associate Professor. Specialist in Anesthesiology and Intensive Care, Chief of the Department of
Anesthesiology and Intensive Care in Pediatrics of Tashkent institute postgraduate medical education. National expert of the WHO
Regional Office. Co-author of the national guidelines for intensive care and management of SARI and the national guidelines for
COVID-19. Member of the COVID-19 Case Management Consultant Group.
Joint Meeting on
