The aim of the research work is the development of production technologies for the substances of preparations Flanorin, Lemarine with hepatoprotective and choleretic action, Cinaroside with hypoazotemic action, improvement of the production technology of the substance of the antiprostatic preparation Ferulen, and the development of feed additives for use in poultry farming.
The scientific novelty of the work is as follows:
a method of sequential extraction of raw materials with water to remove basic impurities and alcohol as a selective extractant for the extraction of flavonoids from the roots of Pseudosophora alopecuroides, which allows obtaining an extract saturated with flavonoids;
the possibility of fractionation of the target products in the liquid-liquid extraction system by changing the polarity of the solvent has been proved and removing green color from a water-alcohol extract was developed;
an industrial technology of obtaining the substance of Lemarin on the basis of the flavonoids of the roots of Ammothamnus Lehmannii was developed;
the optimal conditions for purification the extract from the aerial part of Ferula varia and crystallization of the Cinaroside substance, providing a stable product with its high yield;
the conditions for chromatographic purification of esters of sesquiterpene alcohols on silica gel and drying with addition of filler which ensure the production of ferulene substance with a simplified technology are established;
on the basis of esters of sesquiterpenoid alcohols from the roots of Ferula tenuisecta «Pano-25», «Panoroot- 50» and «Panoroot-98» feed additives for increasing of chickens egg-laying were developed.
