Journal of Biomedicine and Practice

Results of surgical treatment of purulent corneal ulcers by autoconjunctive plastic method in combination with tarzoraphia

2023-07-07T12:10:03+08:00

This article presents the results of surgical treatment of purulent corneal ulcers in 17 patients by the method of autoconjunctival plasty in combination with tarsorraphy. The article describes in detail the technique of the operation and its main advantages. The authors have shown the effectiveness of the proposed method, which is expressed in the fact that in ease of purulent corneal ulcers, the proposed method allows you to preserve the anatomical integrity of the eyeball and improve the patient's rehabilitation process after surgery.

Comparative aspects of pathogenic escherichia in children with acute intestinal diseases and healthy children, sensitivity of pathogenic escherichia to antibacterial drugs

2023-07-05T14:51:35+08:00

The article provides information about the incidence of Escherichia coliosis in children and reflects the relevance of their study. The pathogenic properties of various groups of diarrhoeal Escherichia coli are described. related features of the clinical course and complications in children. The issues of etiological diagnosis of Escherichia coliosis by bacteriological and serological methods are covered. Modern data on the resistance of Escherichia to antibacterial drugs are presented. A bacteriological study was performed on 350 children with OCD of unknown etiology who were hospitalized in the infectious diseases hospital in Moscow. Samarkand and 60 healthy children under 2 years old attending daycare centers.

Immune status of children with coliinfection caused by hemolytic escherichia before and after treatment with bifidumbacterin and colibacterin

2023-07-05T14:52:22+08:00

The aim of the study was to determine the level of immunoglobulins A. M. G. in coli-infection in young children before and after treatment with bifidum-bacterin and colibacterin. Determination of the effectiveness of the use of these probiotics used to correct dysbiotic shifts. A total of 45 young children with coli infection caused by hemolytic Escherichia were monitored. The article presents the main information about the versatile influence of probiotic strains on the formation of resistance of the body of children to hemolytic pathogens of coli-infections and the immune response. The characteristic of humoral protection factors in children with coli infection before and after taking probiotics is given. The effectiveness of bifidumbacterin and colibacterin in the treatment of coli infections was determined.

Aspects relating to the development of vaccination against HBV

2023-07-05T14:52:49+08:00

Chronic hepatitis B virus (HBV) infection is a global public health problem of the same magnitude as tuberculosis, HIV and malaria. The International Coalition to Eliminate HBV (ICE- HBV) is a coalition of experts to accelerate the discovery of a cure for chronic hepatitis B. After extensive consultations with more than 50 scientists from around the world, as well as with key stakeholders, including people affected by it. We believe that research should focus on discovering interventional strategies that will permanently reduce the number of productively infected cells or permanently silence the covalently closed circular DNA in these cells. There is also an urgent need to create repositories of standardized HBV reagents and protocols that can be accessed by all HBV researchers around the world. The HBV cure research agenda set out in this position paper will make a significant contribution to the goal of eliminating HBV infection worldwide.

Changes in polymorphic genes of matrix metalloproteinases (MMPS) and their tissue inhibitors in chronic glomerulonephritis in children

2023-07-05T14:54:06+08:00

In children, glomerulonephritis is a disease characterized by rapid progression and complication caused by an irreversible process of the renal glomeruli. Currently, methods of molecular diagnostics have begun to actively develop, which not only complement traditional research methods, but also provide insight from the point of view of molecular pathophysiology. It is expected that a key role in the diagnosis of kidney disease is played by the identification of genes and their changes in the course of the disease, which predict the course of the disease. Changes in chromosomal polymorphic genes of matrix metalloproteinase and its tissue inhibitors, as well as how this change manifests itself in chronic glomerulonephritis, were determined in the prognosis of the disease.

Study of interaction of blood erythrocytes and immune system parameters in athletes - adolescent

2023-07-05T14:54:29+08:00

The aim of this study was to study the interaction of red blood cells and the parameters of the immune system in adolescent athletes. Questioning and interviewing of 125 young athletes at the age of 11 - 17 years of the city of Samarkand was carried out. Among them there were 81 boys (65.1%), 44 girls (34.9%). In all study groups, there was a tendency to a decrease in the level of immunoglobulin G when comparing two study groups: incubation with saline and a sorbent immobilized with heparin. The obtained research results indicate the undoubted contribution of the components of the complement system to the pathogenesis of immunocomplex inflammation. The study of the activity of the classical complement pathway showed significant changes in the studied blood parameters.

Selection of the scope of surgical treatment for gastric cancer with invasion of the pancreas

2023-07-06T18:34:19+08:00

The article studies to clarify the indications for resection of the pancreas during operations for gastric cancer, to substantiate the proposed methods of resection of the pancreas and the results of surgical treatment of 79 patients with gastric cancer with invasion of the pancreas. On the basis of diagnostic data, patients with gastric cancer were divided into groups based on the depth of invasion into the pancreas. In 39 (49.4%) patients, the depth of germination is more than 5 mm, in 18 (22.8%) patients from 3 to 5 mm, and in the remaining 22 (27.9) patients, the depth of germination is up to 3 mm. Of these, after planar resection of the pancreas R1 resection in 3 (16.6%) patients. Postoperative complications were observed in 11 (13.9%) patients. Of these, mortality is 2 (2.5%). The one-year survival rate was 79.5%, and the three-year survival rate was 39.4%, and the five-year survival rate was 18.4%.

Peculiarities of management of patients during surgical treatment with aldosteroma

2023-07-06T18:47:40+08:00

The work is based on the results of the diagnosis, treatment and medical examination of 13 patients with adrenal aldosteroma (Conn's syndrome) (SC).
The average age of the patients was 36.4±3.1 years, the duration of arterial hypertension was 7.4±2.8 years. There were 4 males (30.8%) and 9 females (69.2%). Right – sided localization was observed in 6 (46.2%) patients, left-sided localization-in 7 (53.8%).
Arterial hypertension was a constant symptom in all the examined patients (n=13). Grade 1 hypertension was observed in 2 (15.4%) patients (BP≤140 – 159/90 – 99 mmHg), 2 degrees – in 5 (38.5%) (BP≤160 – 179/100 – 109 mmHg). The malignant course of the disease (AH 3 st.) was observed in 6 (46.1%) patients (BP≥180/≥110 mm Hg).

Complex treatment of malignant non-organ retroperitoneal sarcomas and their relapses

2023-07-06T19:05:25+08:00

The article discusses the analysis of the results of 84 patients with non-organ sarcomas of the retroperitoneal space, who underwent complex treatment. Tumors of a malignant nature were histologically verified by trepan biopsy in all patients (100%). The patients were divided into 2 groups - main n = 38 and control n = 46. Neoadjuvant chemotherapy was performed in 45.2% of preoperative patients who belong to the study group. All patients underwent radical surgical intervention after 3 courses of PCT. After the operation, they received a course of radiation therapy (TFD-1.8-2Gy). Preoperative chemotherapy resulted in partial tumor regression in 22 (57.9%) patients. Stabilization was observed in 9 (23.7%) patients and progression of the process was noted in 7 (18.4%) patients. Without a relapse period in the main group was 10.2 + 0.4 months, without a metastatic period 11.4 + 0.5 months.

Interventional performance of en-bloc transurethral resection of muscular non-invasive bladder cancer

2023-07-06T19:24:16+08:00

Bladder cancer (BC) is a rather common disease. The incidence of bladder cancer in the population is gradually increasing[3,7] In non-invasive bladder carcinoma (NICM), transurethral resection of bladder tumour (TUR) is the cornerstone of treatment. Successful treatment of these tumours depends on adequate initial resection and an accurate histological diagnosis. After TUR alone, around 50 70% of patients develop recurrence. Reasons for this high rate of recurrence of NICMP have been cited for incomplete resection during the initial TUR, aggressive tumour biology, and implantation of tumour cells[6,8,9].

Palliative surgical treatment of advanced stomach cancer

2023-07-07T11:47:09+08:00

To improve the result of surgical treatment of locally advanced gastric cancer y using palliative resection and gastrectomy.

Comparative analysis of electrosurgical and laser enucleation methods of benign prostatic hyperplasia

2023-07-05T14:50:44+08:00

The article provides an overview of existing methods of enucleation of adenomatous tissue in benign prostatic hyperplasia (BPH). A brief history of the development of endoscopic enucleation techniques is presented. Special attention is paid to modern transurethral techniques of electrosurgical and laser enucleation of prostatic hyperplasia. Data on mono- and bipolar electrosurgical enucleation are presented. The technical features of holmium laser enucleation of the prostate procedure performing are discussed in detail. The features of thulium laser enucleation are also touched upon.

Features of the manifestation of chronic obstructive pulmonary disease in combination with diabetes mellitus

2023-07-07T12:13:11+08:00

The paper identifies the clinical, functional and radiological features of COPD in diabetes mellitus, the possibility of predicting its development. The examined patients were divided into 3 groups: patients with COPD in combination with diabetes mellitus, patients with COPD and patients with diabetes mellitus. In the structure of COPD, the pulmonary component and systemic manifestations arc distinguished, which can aggravate the disease. The manifestations of diabetes mellitus are based on micro- and macroangiopathies that affect pulmonary microcirculation. When managing patients with COPD in combination with diabetes mellitus, attention was drawn to more pronounced clinical manifestations of respiratory failure (shortness of breath, participation in breathing of auxiliary muscles, hypoxemia), especially in stage III COPD, compared to patients with COPD. To diagnose microvascular lesions in patients with COPD and diabetes mellitus, to predict the course of nonspecific lung diseases, based on the specific results of the study, multispiral computed tomography was performed. In patients with COPD, the assessment of the degree of impaired ventilation in the lungs should be carried out under CT conditions performed in the inspiratory and expiratory phases. Diagnostically significant for COPD during computed tomography is a symptom of expiratory "air trap", in combination with expansion and deformation of bronchi of various sizes, up to broncho- and bronchioectasis. When MSCT in patients with COPD and diabetes mellitus, pathognomic changes characterizing microangiopathy and fibrotic changes. The clear-cut shape of microvessels is a specific X-ray morphological sign in patients with COPD in combination with diabetes mellitus.

COVID-19 билан боғлиқ каверноз синус тромбозида тасвирлаш

2023-07-07T12:15:45+08:00

Замонавий тиббиёт радиацион тасвирлаш усулларининг сезиларли даражада ривожланиши ва дсярли барча анатомии сохаларни бахолаш учуй мослаштириши мумкин булган турли режимларнинг пайдо булиши билан ажралиб туради. Ушбу тадкикот натижаларига кура, COV1D-19 билан боглик булган кавсрноз синус тромбозини эрта аниклаш учун тасвирлаш методологиясини таклиф килади. Тромбнинг борлигини аниклаш имкон бсрадиган махсус рсжимларда МРТ тасвирларини тавсифлаш ва изохлаш амалга оширилди. Тадкикот шуни курсатдики, тавсия этилган тасвирлаш усули узига хос аломатлар пайдо булишидан олдин бсморларда тромбозни эрта аниклашга имкон бсради.

Establishment of the preservation of death rating on the basis of studying the extensive brain in conditions of a hot arid zone

2023-07-07T12:16:31+08:00

A study of the medulla oblongata was carried out to establish criteria for the prescription of death in an arid zone from 61 corpses of persons who died from massive blood loss. A gradual increase in autolysis processes is noted, and in the vessels they proceed more intensively than in neurons. In the dynamics of the postmortem period, a comparative characteristic of the morphological and morphometric parameters of neurons and vessels of the medulla oblongata makes it possible to judge the timing of death after massive blood loss in a hot arid zone.

Specific features of the brain structure injury with carbon monoxide in the background of thermal injury and alcoholic intoxication

2023-07-07T12:17:23+08:00

A forensic medical study of 18 corpses of persons who died from various types of carbon monoxide poisoning was carried out. The features of damage to the structures of the brain and cerebellum -nervous tissue, glial complex, vessels and their contents, states of perivascular and pericellular edema, depending on the presence of background (competing) conditions - acute alcohol intoxication, thermal trauma. The obtained data, along with the results of a macroscopic examination of corpses, the results of a forensic chemical analysis on the concentration of carboxyhemoglobin in the blood, allow to establish the direct cause of death of the deceased and to evaluate the thanatogenesis of various variants of carbon monoxide poisoning.

Neuroendocrine structures of lungs in embryogenesis and under conditions of deadaptive remodeling

2023-07-07T12:18:02+08:00

In connection with the increase in the incidence of respiratory organs, interest has revived in the study of fundamental issues related to the diversity of lung cells. The aim of the study was to determine the features of the structural organization of the APUD-systcm of human lungs at different stages of embryonic development, as well as in inflammatory and tumor processes in them. The lungs of human fetuses and newborns, as well as children who died from respiratory diseases and in cancer patients were studied by histological methods. After fixation in Bouin's fluid, paraffin sections were stained using general histological methods: hematoxylin and cosin, according to the Van Gicson and Weigert method. To identify argyrophilic neuroendocrine cells, the sections were impregnated with silver nitrate according to the Grimclius method. Neuroendocrine cells (apudocytes) of the lungs arc determined at the tubular and alveolar stages of organ histogenesis. Branching of the bronchial tree is predetermined by closed apudocytes and neuroepithelial bodies. After birth, their number decreases. With maladaptive remodeling of the lungs caused by inflammation and especially by the tumor process, proliferation of apudocytes of a predominantly closed type occurs, and neuroepithelial bodies are also formed.

Electronic microscopic image of the myocard in diligated cardiomyopathy

2023-07-07T12:18:47+08:00

This paper examines the level of electron microscopy of structural changes that develop in the myocardium as a result of dilated cardiomyopathy (DK.MP). A patient myocardial fragment from DKMP was prepared in a specific order for electron microscopy. The results show that DKMP cardiac-myocardial infarction is manifested by destructive changes in the circulatory and connective tissue, circulatory, edema, dystrophy, destruction submicroscopic structures. Dystrophy, atrophy, and destruction of organelles in the sarcoplasm of cardiomyocytcs led to the destruction of all organelles, including mitochondrial ultrastructure shrinkage, deformation and disintegration of crystals, vacuolation of the matrix, lipidization, and deposition of calcium salts. Myofibrils are characterized by deformation, tearing of sarcomeres, disordered arrangement of actin and myosin structures, separation from each other, in one of which only myosin, in the other actin is stored.

Diliation cardiomyopathy pathomorphology

2023-07-09T22:02:02+08:00

The aim of the investigation was to study the pathomorphological changes in the structures of the myocardium in dilated cardiomyopathy (DCM). We obtained autopsy materials for DCM cases at the Republican Center for Pathological Anatomy over the past 20 years (2010 2020), and also analyzed the autopsy protocols and medical history. Sudden development of heart failure of the right and left ventricles with DCM, cardialgia and angina pectoris; In some cases, with thromboembolism, cardiac arrhythmias were observed, often accompanied by ventricular fibrillation, ventricular extrasystoles and blockade of conduction. Histologically, the following types of pathological changes were observed in the myocardium and endocardium with DCM: excessive proliferation of interstitial connective tissue, the development of myxamatosis, and sometimes lipomatosis. The main changes characteristic of DKMP were muscle fiber dilatation, that is, thinning of muscle fibers, thinning, fragmentation and homogenization of cardiomyocytcs, disordered arrangement of nuclei, and deformation and degeneration due to changes in the environment.

Diagnostic algorithm of dysthymic disorders in chronic alcoholism

2023-07-09T22:19:08+08:00

Dysthymic disorders and a hangover of dependence on alkagol-this is the most observed condition. This condition requires in-depth clinical research and extensive analysis of the course of the disease. In modern psychiatry, the concept of comorbidity is widely used, on the basis of this concept lies the presence of two or more diseases in one patient. Since comorbidity prolongs the clinical picture of the disease, it complicates the diagnosis of the disease for doctors and requires special attention from doctors for treatment. Affektiv in drug-dependent patients, the importance of diagnosing disorders and distinguishing their variants is important. Rapid rational treatment measures arc required to relieve symptoms, otherwise affektiv treatment without eliminating pathology will be ineffective at any level of the disease.

Application the methods of the mnemotechnique in the educational process at medical universities

2023-07-09T22:19:45+08:00

For stable memorizing and remaining in mind a great volume of information that is necessary for further medical activity the mnemotechnique methods can be used on educational process in medical higher schools, that is combination of methods and means making the process of memorizing easier and increasing the memory volume by creating artificial associations. Application of associative method in classes contributes to development of creative activity and logical thinking of students, improves memorizing mechanisms, enriches vocabulary.

Diagnosis and treatment of comorbidity of alcoholism and depressive disorders

2023-07-09T23:31:02+08:00

The combination of alcoholism with depressive disorder is manifested by mild to moderate depressive disorder. Addiction to alcohol often leads to the development and reversal of depression. Depressive disorders also have a significant impact on the nature of alcohol dependence. Ethanol disrupts the metabolism of dopamine, a monoamine in the central nervous system and a neurotransmitter that is mainly involved in controlling the sensitive area. Therefore, the treatment and diagnosis of comarbitis cases with alcoholism and depressive disorders require separate study.

Exudative otitis media in benign tumors of the nose, paranasal sinuses and nasopharynx

2023-07-04T17:04:21+08:00

Exudative otitis media is a polyetiological disease, often caused by a combination of several causal factors. With tumors located near the pharyngeal opening of the auditory tube, early manifestations may be symptoms from the ear and auditory tube - the phenomenon of exudative otitis media.
In this article, we present the features of the clinical course of exudative otitis media in benign neoplasms of the nose, paranasal sinuses and nasopharynx.

Правильное кормление и меры предосторожности при и послеоперационном периоде детей с врожденной расщелиной неба и губы

2023-06-30T22:52:40+08:00

Врожденная расщелина неба (ВРН) может возникать отдельно или одновременно с расщелиной верхней губы. При ВРН возникает не только деформация мягких тканей, но и дефекты и деформации костной ткани разной степени которые намного серьезнее, чем ВРГ, с точки зрения физиологической дисфункции, такой как сосание, еда и язык. Из-за роста и развития челюстей часто происходит коллапс середины лица. В тяжелых случаях оно имеет форму тарелки и имеет нарушенный прикус. Таким образом, различные физические дисфункции, вызванные деформацией волчьей пасти, особенно такие как языковая дисфункция и расстройство зубов, оказывают неблагоприятное воздействие. Оба эти заболевания являются врожденными и в медицине называются врожденными пороками развития ротовой полости.

Optimization of surgical tactics of treatment of patients with injury of the middle facial area

2023-06-30T22:54:11+08:00

Fractures of the bones of the facial skeleton make up from 30 to 40% of the number of dental diseases and up to 21% of all injured patients hospitalized in hospitals. The organization of the algorithm for optimal care for victims in road accidents is based on the principle of excluding the same procedures from different medical institutions. In addition, the diagnostic process is organizedin such a way that the victim with various injuries, upon admission to the appropriate institution or traumatology center, could immediately receive the maximum assistance, taking into account the ability to withstand or postpone the corresponding complex surgical intervention he tactics of treating patients with CTF, according to the developed algorithm, has an undoubted advantage over the previously used one - the percentage of inflammatory complications is reduced to a minimum: from 17% to 1.5%. This approach determines and enhances the role and importance of sorting victims and requires a certain skill from emergency medical specialists, specialists in the admission department and specialist surgeons of specialized or visiting brigades in order to achieve therapeutic effect and recovery results, and, therefore, economic result.

Modern approaches in the diagnosis and treatment of perimplantites

2023-07-03T15:45:25+08:00

This article provides the development of an experimental microbiological model that estimates the effectiveness of the quality of cleaning of the infected titanium surface when using traditional methods of processing and the PERIO-FLOW system. New data indicating the effectiveness of antimicrobial processing of the infected titanium surface when using traditional clinical processing methods and the PERIO-FLOW system. Indicate the speed and quality of the rehabilitation of soft tissues of the peri-implement zone after exposure to the abrasive powder containing the erythritol, which is included in the AIR-Flow Plus powder.

Bases of functional nutrition in dentistry

2023-07-04T13:59:30+08:00

The aim of the study was to assess the effectiveness of the use functional food products aimed at reducing the content of table salt in the body. According to the research results, a positive trend towards an increase in the level of sodium excretion in urine was revealed in students who received functional food products made from local products rich in potassium and low in sodium, developed by us in the standard "Products of functional nutrition NUMA".

Decompression method of treatment of the radicular cyst of the lower jaw

2023-07-04T14:22:20+08:00

Effective decompression of the cyst, which is achieved by creating a "window" in the bone cavity, allows not only sanitizing the cyst cavity with antiseptic solutions, but also obtaining the necessary histological material (bone material and cyst shell) for further research. Subsequent filling of the bone cavity defect with newly formed bone tissue occurs as a result of secondary osteogenesis.

Role of comorbid pathology in the development and severity of parodontal diseases

2023-07-04T14:22:40+08:00

In the course of the study, the need and degree of participation of narrow-profile specialists in the treatment ofparadontal diseases was determined for the timely detection of comorbid pathology and the appointment of adequate therapy.
We studied 225 patients with generalized parodontitis of varying severity. 40 patients without generalized parodontitis (GP) and pathology of the oral mucosa (POM) formed a control group.
Statistically significant differences in the frequency of registered pathology in patients of the compared groups with control indicators, as well as correlations between the frequency of detected diseases and the severity ofparadontal pathology, were established. Thus, the total incidence of previously existing diseases increased in the series of mild generalized parodontitis (MGP), moderate generalized parodontitis (MODERGP) and severe generalized parodontitis (SGP) from 32.47 ± 5.34% with MGP; up to 51.25 ± 3.83% with MODERGP up to 86.96 ± 3.14% in patients with SGP (linear correlation coefficient χ² = 96.167; P ≤ 0.001); the corresponding dynamics of the newly discovered pathology was 42.86 ± 5.63%; 47.65 ± 3.83% and 13.04 ± 3.14% (χ² = 65.087; P ≤ 0.001); and the corresponding frequency of all somatic pathology requiring systematic drug correction was 75.32 ± 4.93%; 99.41 ± 0.52% and 100.00 ± 0.00% (χ² = 235.351; P ≤ 0.001).
Based on the studies performed, local therapy tactics should be determined for the following pathogenetic mechanisms of the development of parodontitis: microcirculation disorders, the prevalence of lipid peroxidation processes, an increase in cytokine aggression and an increase in bone resorption.
When making a diagnosis, the scope and methods of therapy should be maximally individualized based on an assessment of the patient's individual clinical and laboratory parameters, by identifying markers that determine the priority mechanisms of the development of the disease.

Use of general anesthesia in thyroid surgery

2023-07-04T15:16:36+08:00

Thyroid diseases are most common in endocrinology. Thyrotoxicosis induces dysfunction of virtually all organs and systems, the blood circulatory system being subjected to considerable changes. Cardiovascular diseases affect not only the quality of life in a patient, but significantly increase a risk from surgery that is the only radical treatment. For this reason, most authors consider thyrotoxicosis to be a contraindication to elective surgical intervention. At the same time it is known that drug compensation of thyrotoxicosis may be attained in not all patients. In this case, the results of treatment and a patient's safety during surgery depend on the type and quality of anesthetic protection. The capabilities of anesthetic maintenance of thyroid surgery have recently expanded substantially. The paper deals with the preparation of patients with thyrotoxicosis for surgical intervention and the perioperative management of these patients.

Demographics of patients with haemorrhagic and ischaemic stroke

2023-07-04T15:17:01+08:00

At present, the cerebral circulation disorder is caused by various factors. According to the Ministry of Health of the Republic of Uzbekistan, 62876 cases of strokes were registered in Uzbekistan in 2019. 15% acquired lethal outcome, 10-15% returned to their previous state, 55 - 70% became disabled. Stroke is translated from the Latin language as a "stroke" which means an acute cerebral circulation disorder. Regardless of the cause of cerebral circulation disorder, the result is always the same - the death of brain neurons. The most common cause is atherosclerosis on the inner walls of blood vessels that supply the brain. They narrow the blood vessels and make them less flexible. In this case, the probability of clogging the blood vessels with blood clots increases, as a result, the blood vessels cannot supply blood to the brain.

Results of the TGFB1 RS1800471 gene polymorphism in patients with ronophathy with nose respiratory respiration

2023-07-04T15:18:06+08:00

To accurately assess the role of the rs1800471 polymorphism of the TGFb1 gene in the formation of nasal respiratory disorders and the development of rhinopathy, we believe that it is necessary to conduct additional and in depth studies with an increase in the number of patients and individuals in the control group. According to the results of the study, population genetic data turned out to be representative in relatively healthy groups of patients with rhinopathy and control, which allows us to continue working in the following process.

Results of analysis of the C589T RS2243250 polymorphism frequency in the il4 gene in patients with chronic

2023-07-04T15:19:02+08:00

Our results confirm the hypothesis that the presence of an unfavorable genotypic variant of the IL4 gene can lead to a violation of the synthesis (expression) of anti-inflammatory cytokines-interleukins, a decrease in the body's resistance to infectious diseases, and an increase in the risk of developing CPRS. In addition, these data emphasize the prognostic significance of the C/C genotype of the IL4 gene polymorphism in the development of CPRS. The relative risk of developing CPRS in carriers of these genotypes is more than 3 times higher than in carriers of other genotypic variants of IL4 gene polymorphism.

The role of lazer for the treatment of the combinated soft tissue injuries of the facial areas

2023-06-30T22:44:48+08:00

Wounds of the maxillofacial region has several special sighnes that distinguishes from injuries of the remain regions of the human body .This research includes the several dates given about chemical and physical features of the laser and its positive effect on the recovering process of the combinated wounds of the maxillofacial region.

Treatment of exudative otitis means in worldwide practice

2023-07-04T17:05:04+08:00

A literature review on the problem of treatment of exudative otitis media was performed. Exudative otitis media (EMI) is one of the most actively studied diseases of the middle ear in recent decades. Particular interest in this pathology is due to the variety of clinical manifestations of the disease, the duration of the course, the laboriousness of treatment, often resistance to standard therapy for otitis media, and a tendency to relapse. Clinical signs: the presence of exudate in the tympanic cavity, the absence of signs of acute inflammation and defect of the tympanic membrane. Modern medicine is considering many options for the treatment of exudative otitis media, up to the alternative of using hearing aids for patients with contraindications to other types of treatment. On the territory of the CIS, patients are prescribed medication or surgical treatment without active observation tactics, in most European countries and the United States, a wait-and see approach is used.

Indicators of the quality of life of patients with chronic supperative otitis media after tympanoplasty

2023-07-04T17:05:23+08:00

Chronic suppurative otitis media is characterized by clinical symptoms of decreased or loss of hearing acuity, otorrhea, congestion, noise and pain in the ears, and headaches. Health-related quality of life is an important parameter today. In order to determine the success of a surgical intervention, it is necessary both to improve the objectively measured parameters and it is important to supplement them with an improvement in the patient's quality of life.

Efficacy of histamine h2-receptor blockers in children with nephrotic syndrome receiving glucocorticosteroid therapy

2023-07-04T17:35:50+08:00

Clinical and laboratory studies were conducted in 46 children from 12 to 18 years of age. Of these, there were 30 girls and 16 boys. All children received glucocorticosteroid therapy for nephrotic syndrome. According to the results of esophagogastroduodenoscopy, all children had lesions of the gastroduodenal zone. 1 group of patients was prescribed a drug from the group of histamine H2- receptor blockers - ranitidine 300 mg. After therapy, 85% of group 1 children were found to have eradication of erosive lesions of the gastroduodenal zone

The role of risk factors in the development of unstable variants of stenocardia in young and elderly men with dyslipidemia

2023-07-04T17:36:14+08:00

Patients with unstable variants of angina pectoris have risk factors that contribute to the early development and progression of coronary artery atherosclerosis. According to a number of studies, a large contribution to the development of unstable variants of angina pectoris is made by the main behavioral risk factors (smoking, excessive alcohol consumption, improper and unhealthy diet, reduced physical activity, fatigue), which naturally leads to the development of obesity, dyslipidemia and diabetes mellitus

Surgical treatment of injuries of the rotary cuff of the shoulder joint

2023-07-04T17:36:58+08:00

Injuries to the upper urinary tract occur in 63–84% of shoulder injuries. In terms of the incidence of rotator cuff injuries, it ranks third (16%) after diseases of the spine (23%) and knee joint (19%). In the Samarkand Branch of the Republican Specialized Scientific and Practical Medical Center of Traumatology and Orthopedics, 66 patients (41 men, 25 women) were operated openly (from 2014 to 2020) with a diagnosis of chronic damage to the tendons of the rotator cuff of the shoulder, combined contracture of the shoulder joint. The average age of the patients was 58 years. In 16 patients (24.2%), the causes of damage to the rotator cuff were injuries of various mechanisms, and in 50 patients (75.8%). Excellent results were obtained in 38 patients (57.5%). A good result was obtained in 25 patients (37.8%). An unsatisfactory result was obtained in 3 patients (4.7%)

Қўшилиб келгaн aбдоминaл пaтология вa қорин чуррaлaридa хирургик ёндaшувлaрни тaктик-техник aспектлaри

2023-07-04T18:52:20+08:00

Вентрал чурра касаллигига чалинган 197 беморни жарроҳлик даволаш натижалари таҳлил қилинди, шундан 104 (52,8%) беморга бир вақтнинг ўзида қорин бўшлиғи аъзоларининг ва қорин олд деворининг жарроҳлик патологиясини коррекциялаш бўйича симултан операциялар ўтказилди. Беморларнинг 20,1% га операциянинг симултан босқичи алоҳида минилапаротомик йўл билан амалга оширилди. Шундан таранглашган аллопластика усуллари 48,2% га, таранглашмаган - 51,8% га ва беморларнинг 26,4% да дерматолипидектомия қилинган. Вентрал чурра касаллиги билан оғриган беморларда қорин девори ва қорин бўшлиғи аъзоларига симултан операцияларни ўтказишда стресс гормонларининг даражасини ўрганиш шуни кўрсатдики, жарроҳлик агрессия даражасига ва операция давомийлигига қорин олд деворининг пластикасининг "таранглашган" усули кўпроқ таъсир кўрсатди. Қорин бўшлиғи аъзоларининг патологиясини коррексиялаш бўйича операция етапи стресс гормонлари даражасига сезиларли таъсир кўрсатмади.

Surgical tactics in patients with liver echinococcosis

2023-07-04T18:53:04+08:00

Based on the analysis of the case histories of 327 patients with liver echinococcosis (LE), surgical treatment tactics were developed taking into account optimal access depending on the location of the cyst; indications for biliary tract decompression, including using endoscopic techniques, were determined.

Modern state of the problem of diagnosis of thyroid nodules (literature review)

2023-07-05T14:14:05+08:00

The question of modern possibilities of complex diagnostics of thyroid nodules is considered. Despite the large number of studies conducted, it is not always possible to correctly establish an accurate morphological diagnosis of thyroid nodules, which indicates the need to improve existing and search for new, more informative diagnostic methods. In this regard, reports on the use of measurements of tissue pressure in the thyroid gland for the differential diagnosis of various pathologies of this organ are very promising.

Surgical treatment of gallstone disease (literature review)

2023-07-05T14:30:20+08:00

The article describes modern methods of diagnosis and treatment of acute cholecystitis and its complications in cholelithiasis. In the literature, data on the problem of treating choledocholithiasis are contradictory. The question of evaluating the effectiveness of various treatment technologies remains open and requires further in-depth study. The introduction of new methods and technologies in the treatment of patients with choledocholithiasis not only did not bring clarity to the solution of issues related to the tactics of treating such patients, but, on the contrary, increased the contradictions.