CURRENT APPROACHES AND NEW RESEARCH IN
MODERN SCIENCES
International scientific-online conference
75
CLINICAL AND IMMUNOLOGICAL CHARACTERISTICS OF STABLE
ANGINA PECTORIS IN ELDERLY WOMEN WITH CONCOMITANT
ARTERIAL HYPERTENSION
Kamilova Shakhzoda Rakhmatovna
Bukhara State Medical Institute, Republic
of Uzbekistan, Bukhara
https://doi.org/10.5281/zenodo.15653964
Annotation
A comprehensive examination of 208 elderly women (60-74 years; mean
age 66.0±6.0 years) with ischemic heart disease and arterial hypertension of II–
III degrees was conducted. The main group consisted of patients with stable
angina pectoris (SS) of functional classes I-III: FC-1-58 (32.6%), FC-2 — 62
(34.8%), FC-3 — 58 (32.6%). The comparison group included 30 patients with
progressive angina pectoris. Clinical, biochemical and immunological
parameters were studied. The relationship between the level of cytokines and
the severity of the disease was revealed. Prognostic criteria for the course of SS
in elderly women with hypertension have been developed, which help clarify the
diagnosis and individualize therapy.
Keywords
Stable angina, arterial hypertension, elderly women, cytokines,
immunological indicators, prognosis, diagnosis.
Relevance
The combination of stable angina and arterial hypertension in elderly
women is a complex clinical and diagnostic problem due to progressive vascular
and immunological disorders. According to epidemiological studies, more than
65% of women over 60 years of age suffer from hypertension, and symptoms of
stable angina occur in 25-30% of this population. Age-related changes in the
immune system, an imbalance in the cytokine profile, and the severity of
endothelial dysfunction contribute to the aggravation of the clinical course of
coronary heart disease. At the same time, clear prognostic immunological
criteria for assessing the severity of stable angina in elderly women with arterial
hypertension have not been developed. This determines the need for a
comprehensive assessment of clinical, biochemical and immunological
parameters, which will improve risk stratification, increase the diagnostic value
of the examination and individualize therapeutic approaches for this category of
patients, reducing the risk of cardiovascular complications and disease
progression.
CURRENT APPROACHES AND NEW RESEARCH IN
MODERN SCIENCES
International scientific-online conference
76
Research objective
Comprehensive clinical and immunological diagnostics of stable angina
pectoris in elderly women with arterial hypertension and development of
prognostic criteria for its severity.
Materials and methods
The study included 208 women with IHD and grade II–III arterial
hypertension aged 60-74 years (mean age 66.0±6.0 years). The main group
consisted of patients with stable angina: FC-1-58 (32.6%), FC-2 — 62 (34.8%),
FC-3 — 58 (32.6%). The comparison group consisted of 30 women with
progressive angina pectoris. Clinical and instrumental data, peripheral blood
parameters, biochemical status, cytokine levels (IL-6, TNF-α), CIC, and the
content of lymphocytic subpopulations were studied. General clinical,
anthropometric, biochemical, immunological, functional and statistical research
methods were used.
Results
In women with stable FC-3 angina, a significant increase in the level of IL-6
to 15.2±1.4 pg/ml and TNF-α to 19.7±1.6 pg/ml was detected compared to FC-1
(IL-6 — 8.6±0.9 pg/ml, TNF-α — 11.2±1.3 pg/ml).ml; p<0.01). The CIC level was
maximal in FC-3 — 123.4±5.2 U/ ml versus 84.6±4.3 U/ ml in FC-1 (p<0.05). The
CD4+/CD8+ index increased with the progression of angina pectoris FC (up to
2.8±0.2; p<0.05). Significant correlations were found between immune markers
and clinical manifestations of the disease (r=0.62-0.68; p<0.01).
Conclusion
In elderly women with stable angina pectoris and grade II–III arterial
hypertension, pronounced immune disorders were detected: activation of pro-
inflammatory cytokines (IL-6, TNF-α), increased CIC levels, and shifts in
субпопуляцияхT-lymphocyte subpopulations. The severity of these changes
depended on the functional class of angina pectoris, which allows us to use them
as prognostic markers of the severity of the disease. The developed clinical and
immunological indicators increase the informative value of diagnostics,
contribute to more accurate risk stratification and individualization of treatment
of patients in this category. The results of the study are recommended for
implementation in practical healthcare in the examination of elderly women
with CHD and hypertension.
CURRENT APPROACHES AND NEW RESEARCH IN
MODERN SCIENCES
International scientific-online conference
77
Литература:
1.
Khamdamov B. Z., Umarov B. Y. COMBINED LOCAL TREATMENT OF LONG-
TERM NON-HEALING WOUNDS://Collection of abstracts of the scientific and
practical conference «Current Problems of Surgical Soft Tissue
Infections»(2024), Tashkent, October 28 //JOURNAL OF EDUCATION AND
SCIENTIFIC MEDICINE. – 2024. – Т. 1. – №. 5. – С. 7-8.
2.
Умаров Б. Я., Мемиров Б. М., Латыпова З. Г. ВЛИЯНИЕ САНИТАРНО-
ГИГИЕНИЧЕСКИХ УСЛОВИЙ ПРОЖИВАНИЯ НАСЕЛЕНИЯ И КАЧЕСТВА
ВОДОПРОВОДНОЙ ВОДЫ НА ЗАБОЛЕВАЕМОСТЬ ОСТРЫМИ КИШЕЧНЫМИ
ИНФЕКЦИЯМИ //Гигиена и санитария. – 1991. – №. 1. – С. 29-30.
3.
Umarov B. Y. THE NATURE OF NECROBIOTIC PROCESSES OF LONG-TERM
NON-HEALING WOUNDS://Collection of abstracts of the scientific and practical
conference «Current Problems of Surgical Soft Tissue Infections»(2024),
Tashkent, October 28 //JOURNAL OF EDUCATION AND SCIENTIFIC MEDICINE. –
2024. – Т. 1. – №. 5. – С. 9-10.
