CURRENT APPROACHES AND NEW RESEARCH IN
MODERN SCIENCES
International scientific-online conference
77
MODERN CONCEPTS OF SIDE EFFECTS OF LOCAL ANESTHETICS
Tillaev Saidbek Sobir ugli
Bukhara State Medical Institute
https://doi.org/10.5281/zenodo.13354723
Most surgical procedures are accompanied by pain of varying intensity, so
pain relief is one of the most pressing issues in traumatology. Local anesthetic
drugs are considered safe for use in traumatology. The cause of adverse
reactions in the form of paresthesia in both surgical and non-surgical
traumatological interventions using drugs from the local anesthetic group is
usually associated with direct trauma from injection, edema, hematoma [19].
Paresthesia is defined as neuropathy with altered sensations and persistent
anesthesia with a variety of symptoms, including sensory dysfunction [20, 21].
Studies have been conducted to study the cause of paresthesia
development due to potential neurotoxicity of local anesthetics [19, 23–26]. In
the study by Piccini C. et al., aimed at assessing possible adverse reactions due to
the use of local anesthetics, cases of adverse reactions to lidocaine, bupivacaine,
articaine, prilocaine, and mepivacaine were analyzed [19]. Data confirming the
neurotoxicity of local anesthetics are included in the study results and confirm
the persistence of paresthesia after injection. The severity of paresthesia was
also associated with the duration of altered sensations.
Despite the fact that in most cases the nerve affected by the anesthetic can
spontaneously recover within 8 weeks, in some cases this side effect may not be
eliminated within 6–18 months or may not even go away at all due to the
inability to restore excitation conduction along the nerve fiber. This ADR was
observed with the use of articaine, lidocaine and prilocaine. All ADRs reported
with the use of any local anesthetic were summarized. From 2014 to 2021,
17,246 reports on any ADRs of local anesthetics were collected, resulting in
18,574 pairs (DR/ADR). It was found that the most severe ADRs are various
types of paresthesia, in some cases (2-3%) persisting for life. The significance of
pairs may be higher, since one ADR may be associated with several drugs. The
maximum number of cases of paresthesia was established for lidocaine,
bupivacaine, articaine.
Tissue damage during histological examination was detected with the
administration of a 4% solution of articaine and was not detected with the
administration of a 2% solution [19]. In the study by Pogrel M.A. [23] also
showed how unsafe the use of anesthetics is, and emphasized the possibility of
developing paresthesia with prilocaine in 34% of the studied cases, articaine - in
CURRENT APPROACHES AND NEW RESEARCH IN
MODERN SCIENCES
International scientific-online conference
78
33%, lidocaine - in 25%, respectively. The authors concluded that all local
anesthetics are neurotoxic.
In the study of Gaffen A.S. et al. [24], non-surgical trauma interventions were
analyzed over 11 years. During the study period, about 60% of cases of
paresthesia were associated with the use of articaine solution, about 16% - with
the use of prilocaine, about 13% - lidocaine, about 3% - mepivacaine, there were
no reports of paresthesia with the use of bupivacaine. All drugs were
administered in a dose of about 1.8 ml, in the form of a 4% solution. In the study
of Garisto G.A. et al. [25] Also, only cases of non-surgical intervention over 11
years with the introduction of articaine, bupivacaine, lidocaine, mepivacaine,
prilocaine were analyzed.
References:
1.
Олимова А. З., Шодиев У. М. Репродуктив Ёшдаги эркакларда
бепуштлик сабаблари: Бухоро тумани эпидемиологияси //Scientific
progress. – 2021. – Т. 2. – №. 7. – С. 499-502.
2.
Zokirovna O. A., Abdurasulovich S. B. Ovarian Diseases in Age of
Reproductive Women: Dermoid Cyst //IJTIMOIY FANLARDA INNOVASIYA
ONLAYN ILMIY JURNALI. – 2021. – Т. 1. – №. 6. – С. 154-161.
3.
Olimova A. Z. ECHINOCOCCOSIS OF LIVER OF THREE MONTHLY WHITE
RAT //Scientific progress. – 2022. – Т. 3. – №. 3. – С. 462-466.
4.
Олимова А. З. Морфологические и морфометрические особенности
печени белых беспородных трех месячных крыс после тяжёлой черепно-
мозговой травмы вызванной экспериментальным путём //BARQARORLIK
VA YETAKCHI TADQIQOTLAR ONLAYN ILMIY JURNALI. – 2021. – Т. 1. – №. 6. –
С. 557-563.
5.
Oglu M. Z. M., Zokirovna O. A. МОРФОЛОГИЧЕСКИЕ И
МОРФОМЕТРИЧЕСКИЕ ПАРАМЕТРЫ ПЕЧЕНИ БЕЛЫХ БЕСПОРОДНЫХ КРЫС,
ПЕРЕНЕСШИХ ЭКСПЕРИМЕНТАЛЬНУЮ ЧЕРЕПНО-МОЗГОВУЮ ТРАВМУ
ПОСЛЕ МЕДИКАМЕНТОЗНОЙ КОРРЕКЦИИ //JOURNAL OF BIOMEDICINE AND
PRACTICE. – 2023. – Т. 8. – №. 1.
6.
Олимова А. З., Турдиев М. Р. БУХОРО ШАҲРИДА МЕЪДА ВА ЎН ИККИ
БАРМОҚЛИ ИЧАК ЯРАСИ УЧРАШ ЭПИДЕМИОЛОГИЯСИ //Oriental
renaissance: Innovative, educational, natural and social sciences. – 2022. – Т. 2. –
№. 4. – С. 642-647.
7.
Zokirovna O. A. Modern Concepts of Idiopathic Pulmonary Fibrosis
//American Journal of Pediatric Medicine and Health Sciences. – 2023. – Т. 1. –
№. 3. – С. 97-101.
CURRENT APPROACHES AND NEW RESEARCH IN
MODERN SCIENCES
International scientific-online conference
79
8.
Zokirovna O. A. Pathology of Precancerous Conditions of the Ovaries
//American Journal of Pediatric Medicine and Health Sciences. – 2023. – Т. 1. –
№. 3. – С. 93-96.
9.
Зокировна, Олимова Азиза и Тешаев Шухрат Джумаевич.
«Морфологические аспекты печени белых беспородных крыс после
тяжелой черепно-мозговой травмы, вызванной экспериментально в виде
дорожно-транспортного происшествия». Scholastic: Journal of Natural and
Medical Education 2.2 (2023): 59-62.
10.
Zokirovna O. A. Comparative characteristics of the morphological
parameters of the liver at different periods of traumatic brain injury //Euro-Asia
Conferences. – 2021. – С. 139-142.
11.
Zokirovna O. A. Macroand microscopic structure of the liver of
threemonthly white rats //Academic research in educational sciences. – 2021. –
Т. 2. – №. 9. – С. 309-312.
12.
Олимова А. З. Частота Встречаемости Миомы Матки У Женщин В
Репродуктивном Возрасте //BARQARORLIK VA YETAKCHI TADQIQOTLAR
ONLAYN ILMIY JURNALI. – 2021. – Т. 1. – №. 6. – С. 551-556.
13.
Zokirovna O. A., Abdurasulovich S. B. Ovarian Diseases in Age of
Reproductive Women: Dermoid Cyst //IJTIMOIY FANLARDA INNOVASIYA
ONLAYN ILMIY JURNALI. – 2021. – Т. 1. – №. 6. – С. 154-161.
14.
Zokirovna O. A. Cytological screening of cervical diseases: pap test
research in the bukhara regional diagnostic center for the period 2015-2019. –
2022.
15.
Zokirovna O. A., PREVALENCE R. M. M. EPIDEMIOLOGY OF CANCER OF
THE ORAL CAVITY AND THROAT IN THE BUKHARA REGION //Web of Scientist:
International Scientific Research Journal. – 2022. – Т. 3. – №. 11. – С. 545-550.
16.
Olimova A. Z. The frequency of occurrence of my uterus In women of
reproductive age //JOURNAL OF ADVANCED RESEARCH AND STABILITY
(JARS). – 2021. – Т. 1. – №. 06. – С. 551-556.
17.
Olimova Aziza Zokirovna. (2023). MODERN PRINCIPLES OF THE EFFECT
OF HEMODIALYSIS THERAPY ON HEART RATE. International Journal of
Integrative and Modern Medicine, 1(1), 80–85. Retrieved from
http://medicaljournals.eu/index.php/IJIMM/article/view/28
18.
Olimova
Aziza
Zokirovna.
(2023).
PATHOMORPHOLOGICAL
CHARACTERISTICS OF THE EPIDIDYMIS UNDER IRRADIATION. International
Journal of Integrative and Modern Medicine, 1(1), 96–100. Retrieved from
http://medicaljournals.eu/index.php/IJIMM/article/view/31
CURRENT APPROACHES AND NEW RESEARCH IN
MODERN SCIENCES
International scientific-online conference
80
19.
Olimova Aziza Zokirovna. (2023). THE INCIDENCE OF CANCER OF THE
ORAL CAVITY AND PHARYNX IN THE BUKHARA REGION. International Journal
of Integrative and Modern Medicine, 1(1), 86–89. Retrieved from
http://medicaljournals.eu/index.php/IJIMM/article/view/29
20.
Olimova Aziza Zokirovna. (2023). INFLUENCE OF ALCOHOL
INTOXICATION ON THE HEART TISSUE OF RATS IN THE EXPERIMENT.
International Journal of Integrative and Modern Medicine, 1(1), 90–95.
Retrieved from http://medicaljournals.eu/index.php/IJIMM/article/view/30
21.
Olimova Aziza Zokirovna. (2023). Modern Aspects of the Etiology of
Gastric Ulcer and Its Complications. American Journal of Pediatric Medicine and
Health
Sciences
(2993-2149),
1(3),
163–166.
Retrieved
from
http://grnjournal.us/index.php/AJPMHS/article/view/208
22.
Zokirovna O. A., Jumaevich T. S. Morphological Aspects of the Liver of
White Outbred Rats After Severe Traumatic Brain Injury Caused Experimentally
in the Form of a Road Accident //Scholastic: Journal of Natural and Medical
Education. – 2023. – Т. 2. – №. 2. – С. 59-62.
23.
Aziza Zokirovna Olimova GASTRIC ULCER AND ITS COMPLICATIONS //
Scientific progress. 2022. №3. URL: https://cyberleninka.ru/article/n/gastric-
ulcer-and-its-complications (дата обращения: 28.09.2023).
24.
Olimova Aziza Zokirovna. (2022). TECHNIQUE FOR CUTTING BIOPSY AND
SURGICAL MATERIAL IN THE PRACTICE OF PATHOLOGICAL ANATOMY AND
FORENSIC MEDICINE. Web of Scientist: International Scientific Research Journal,
3(7), 116–120. https://doi.org/10.17605/OSF.IO/PSQ59
25.
Zhumayevich N. F., Zokirovna O. A. PATHOMORPHOLOGY OF GASTRIC
CANCER //BARQARORLIK VA YETAKCHI TADQIQOTLAR ONLAYN ILMIY
JURNALI. – 2022. – С. 330-333.
26.
Zokirovna O. A. Epidemiological and Etiological Data of Morphogenesis
and Pathomorphology of Congenital Heart Diseases in Children //American
Journal of Pediatric Medicine and Health Sciences. – 2023. – Т. 1. – №. 4. – С. 88-
91.
