156
Volume 5, Issue 10: Special Issue
(EJAR)
ISSN: 2181-2020
MPHAPP
THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL
CONFERENCE
“
MODERN PHARMACEUTICS: ACTUAL
PROBLEMS AND PROSPECTS
”
TASHKENT, OCTOBER 17, 2025
in-academy.uz
DEVELOPMENT OF A TRANSDERMAL MEDICINE FOR WOUND HEALING
Nikitin K.A.
Zhilyakova E.T.
Belgorod State National Research University, Belgorod, Russian Federation
e-mail: sovelij7478@gmail.com, phone +79087895220
https://doi.org/10.5281/zenodo.17328605
Relevance:
the relevance is due to the high prevalence of wound pathology and the lack of
complex and effective means for its treatment in the domestic pharmaceutical market.
Purpose of the study:
development of a transdermal dosage form of wound healing action
Materials and methods:
analytical research methods and computer modeling methods were
used in the work
Results:
in order to reduce the development time and material costs, 8 compositions containing
benzyl dimethyl[3-(myristoyl amino) as an antimicrobial component were selected using the Syntelly
artificial intelligence platform for organic and medical chemistry.propyl]ammonium (miramistin),
xymedon, or acecsamic acid as a reparant, as well as 1 of 5 NSAIDs: ketoprofen, ketorolac,
benzydamine, nimesulide, or phenylbutazone, which are predicted to be stable. Three design options
for a transdermal system have been proposed to provide controlled prolonged release. (pict.1).
Picture 1.
Schemes of proposed designs of transdermal therapeutic systems with wound-
healing effect: matrix (A), reservoir (B), and combined (C).
Conclusions:
possible compositions and designs of a transdermal therapeutic system have been
developed and theoretically substantiated.
А
1 -
Подложка
Б
1 -
Подложка
2 –
Адгезив с растворенным ЛВ
2 -
Резервуар с растворенным ЛВ
3 –
Защитная пленка
3 -
Мембрана
4 -
Адгезив
5
- Защитная пленка
В 1 -
Подложка
2 -
Резервуар с растворенным ЛВ
3 -
Мембрана
4 -
Адгезив с растворенным ЛВ
5
- Защитная пленка
