№ 10(MPHAPP) (2025) THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL CONFERENCE “MODERN PHARMACEUTICS: ACTUAL PROBLEMS AND PROSPECTS”

Статьи

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  HERBAL REMEDIES IN THE TREATMENT OF ANTI-ULCER DRUGS Peptic ulcer disease (PUD) holds a special place among chronic diseases of the gastrointestinal tract due to its prevalence and severity. We know that in most cases, synthetic drugs are taken which have a pronounced pharmacotherapeutic effect. However, they also have side effects on other functional organs. This limits their possible use in some cases (for children and pregnant women) as well as for individual intolerance to synthetic drugs. In this regard, the use of medicinal plants with anti-ulcer effects is relevant.

  R Sultanova , F Kulboeva, A Kholboev

  476

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  CHANGES IN THE PHYSICAL ENDURANCE OF MICE BASED ON THE RESULTS OF A SWIMMING TEST BASED ON THE COMBINED USE OF ACTOPROTECTIVE AGENTS Physical performance is a key indicator of the functional state of the body, reflecting the ability to exercise and fatigue resistance. In sports physiology and pharmacology, endurance assessment is important in developing training programs and testing various effects. Mice are widely used as models due to their genetic uniformity and sensitivity. The swimming to exhaustion test is a valid method of assessing endurance

  M Tagangylyjova , A Kasymov

  477

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  CARDIAC MARKERS IN THE BLOOD OF RATS EXPOSED TO FREE AND BOUND DOXORUBICIN The anthracycline antibiotic doxorubicin (DOX) is widely used in clinical practice for the treatment of cancer; however, its high cardiotoxicity limits its use. The development of targeted delivery systems for the cytostatic agent to the tumor site has significantly reduced DOX toxicity. Research in this area has also been conducted at the Institute of Bioorganic Chemistry of the Academy of Sciences of the Republic of Uzbekistan, where various DOX derivatives have been obtained. Comprehensive studies are currently underway on the promising polysaccharide conjugated drug PGA-DOX. To assess the cardiotoxic effect of various drugs, levels of various cardiac markers are determined.

  N Tagayalieva , Sh Usmonov , A Abdullaev , M Zaripova , K Baratov , R Yakubova , G Rakhmonova , B Mukhitdinov , M Kalonova , A Turaev

  478-479

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  INVESTIGATION OF THE SPECIFIC EFFECT OF A DENTAL GEL BASED ON THE HANDELIA PLANT Due to the high prevalence of oral inflammatory diseases among the population of our republic, the development of natural-based dental gels and the study of their activity is considered relevant.

  N Temirova, Z Fayziyeva

  480

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  THERAPEUTIC STRATEGIES FOR CEREBRAL ATHEROSCLEROSIS UNDER HIGH-ALTITUDE CONDITIONS: ADAPTIVE-METABOLIC CORRECTION Cerebral atherosclerosis under high-altitude conditions has a more severe course due to chronic hypobaric hypoxia, which enhances mitochondrial dysfunction, lipid peroxidation, and energy deficit in brain cells. This leads to faster progression of cognitive impairments and increases the risk of ischemic stroke. The search for therapeutic strategies focused not only on the vascular component but also on adaptive-metabolic support is a pressing task.

  M Taalaibekova , Zh Makhmudova

  481

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  STUDYING THE ANTIANEMIC ACTIVITY OF THE PREPARATION FOLIC ACID Anemia is a group of diseases characterized by a decrease in the number of circulating red blood cells and (or) hemoglobin (Hb) in a unit of blood volume below the normal level for a given age and gender. Today, the relevance of the anemia problem remains high: every fourth person in the world suffers from anemia, and women and children are especially affected. Anemia is a common symptom of a wide range of diseases, including malignant tumors, and requires attention due to its severe consequences for health and quality of life, especially in Africa and Southeast Asia. Prevention and treatment of iron deficiency is one of the most important health problems in many countries around the world. In the treatment of anemia, folic acid plays a key role, ensuring the process of formation of blood cells (erythrocytes) when there is a lack of iron in the body. Stimulates erythropoiesis, participates in the synthesis of nucleic and amino acids, purine and pyrimidine bases, in the metabolism of choline and histidine.

  B Tulyaganov , R Tulyaganov , H Usmanova

  482-483

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  DETERMINATION OF THE ACUTE TOXICITY OF WILD PEAR (PYRUS PYRASTER) DRY EXTRACT As is known from the literature, the fruit of pear (Pyrus communis) has been used as food since ancient times. There are more than 22 species of it, one of which is the wild pear, which is the ancestor of the modern cultivated pear. Diabetes mellitus remains one of the most urgent problems of clinical medicine. Diabetes mellitus is the third leading cause of death from this disease (6%), after cardiovascular diseases (51%) and cancer (17%). Over the past 10 years, the incidence of diabetes mellitus has increased in all countries of the world. Children under the age of 14 account for 6-8% of the population with diabetes. The annual increase in the number of children with insulin-dependent diabetes is 6%. Up to 13% of children with diabetes are under the age of 5. Due to the high content of beneficial substances in the composition of wild pear, it has been used: for diuretics, inflammation, normalization of blood pressure, and boosting immunity. Scientific research in recent years has shown that natural compounds consisting of polyphenols and polysaccharides in their chemical composition are used to prevent the development of obesity and diabetes (by reducing the amount of glucose in the blood).

  U Berdibaev , B Tulyaganov , R Tulyaganov

  484

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  STUDY OF THE EFFECT OF THE SUBSTANCE “ALFAMANKOR” ON HEPG2 CELLS Liver cancer, particularly hepatocellular carcinoma (HepG2), is one of the most common cancers worldwide, with a high mortality rate. Current chemotherapeutic agents often have significant side effects, and their effectiveness is limited. Therefore, the search for new, effective, and less toxic compounds is considered a key area of research in oncology

  D Khayrullaev , Sh Gulyamov , R Zakirova , F Jumaboev , A Sharipov

  485

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  ИССЛЕДОВАНИЯ ПО ОСТРОЙ И ХРОНИЧЕСКОЙ ТОКСИЧНОСТИ БИОЛОГИЧЕСКОЙ АКТИВНОЙ ДОБАВКИ «АС-КУРКУМИН» Разработка новых фармакологически эффективных лекарственных средств (ЛС) или биологически активных добавок (БАД) включает совершенствование технологий получения, а также подбор вспомогательных веществ и наполнителей, способствующих улучшению биодоступности и стабильности активных компонентов. ЛС и БАД растительного происхождения представлены в различных лекарственных формах и включают стандартизованные экстракты, эфирные масла и выделенные биологически активные соединения. Одним из направлений расширения ассортимента растительных лекарственных средств является углублённое фармакологическое изучение уже известных фармакопейных растений, традиционно применяемых при ограниченном числе показаний. Многие из них обладают потенциалом для более широкого терапевтического использования. Перспективным представляется также формирование рациональных многокомпонентных фитокомпозиций, содержащих совокупность биологически активных веществ с полифункциональным фармакологическим действием, направленным на регуляцию физиологических процессов в функционально взаимосвязанных системах организма

  К.Ш. Мухитдинова, З.А. Юлдашев, И.З. Закиров, С.А.Мухитдинов

  486-487

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  HYGIENIC CHARACTERISTICS OF WORKING CONDITIONS IN THE PHYTOCHEMICAL SECTOR OF THE "SULTON MEDPHARM" LLC PRODUCTION In the Republic of Uzbekistan, the task of creating its own industrial pharmaceutical base, capable of solving many problems related to production conditions, is currently acute. To ensure the creation of optimal working conditions in pharmaceutical enterprises operating under our natural and climatic conditions, it is already necessary to have a comprehensive hygienic characterization of pharmaceutical production.

  I Rustamov , N Olimov , M Abdullaeva , Sh Nurmatov

  488-489

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  INFLUENCE OF DIHYDROQUERCITIN ON RESTORATION OF LACTATE CONTENT IN BLOOD IN HIGHLY SKILLED ROWERS Today, the constant growth of sports results in canoeing requires intensification of the athletes' training system. To improve the performance of high-class rowers, the use of biologically active additives is in high demand. As such, dihydroquercetin, which has antioxidant, capillary protective, anti-inflammatory properties, as well as positively affecting the functioning of the cardiovascular, immune, nervous and respiratory systems, has not been studied

  J Abdurakhmanov , L Kuchkarova

  490

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  DETERMINATION OF ANTIOXIDANT AND ANTIRADICAL PROPERTIES OF GOSSITAN AND SAFFLOWER EXTRACTS selective gossitan consists of studying the antioquism as well as antiradicality nature of safflower extracts. To achieve the purpose of the work, we used the following research tasks. Study of solubility and properties of extracted gossitan, gallora extracts. Determination of the antioxidant and antiradicality properties of selected gossitan, gallora extracts. The effect of Gossitan and safflower extracts on LPO and oxygen balance in the body

  G Qalandarova

  491

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  ANTICOAGULANT PROPERTIES OF ENDOPHYTIC FUNGI FROM CERTAIN MEDICINAL PLANTS OF THE CHATKAL BIOSPHERE RESERVE In the current era of modern technologies, the supply of medicines is an important issue in the treatment of diseases caused by heredity, gene mutations, cell membrane disorders of higher organisms, climate degradation, and other causes, including in the situation caused by the coronavirus. One of the complications remaining after the COVID-19 disease, which has spread throughout the world, is the state of platelet aggregation. This naturally increases the demand for the production of blood thinners (for example, heparin, cleacsan, etc.). In the context of the current pandemic, one of the urgent problems is the search for cost-effective substitutes for such drugs using the anticoagulant properties of endophytic fungi, their screening and recommendation for pharmaceuticals and medicine

  M Boʻrieva , X Nuralieva

  492

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  ANTIMICROBIAL PROPERTIES OF IONOGENIC INULIN DERIVATIVES World medical practice faces the problem of increasing number of infectious diseases that are difficult to treat with known antimicrobial agents. First of all, this is due to a sharp increase in the number of resistant microorganisms to existing drugs and a decrease in their therapeutic effectiveness due to uncontrolled administration. In such conditions, the need for the development of new antimicrobial agents based on natural polymers increases. Of particular interest are compounds that can combine antimicrobial activity with a minimal risk of side effects. It is known that polysaccharides such as chitosan, pectin, alginic acid and their derivatives have a wide spectrum of antimicrobial action. At the same time, antimicrobial polysaccharides do not exhibit toxic effects and do not accumulate in the body. Based on this, research aimed at obtaining new polysaccharide derivatives with antimicrobial action remains relevant.

  A Jonuzokov , O Abdullaev , A Khusenov , G Rakhmanberdiev

  493

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  THE INFLUENCE OF THE ORGANIC NITROGEN SOURCE CONTENT ON THE ACTIVITY OF CHOLESTEROL OXIDASE PRODUCER Cholesterol oxidase (CHO) is an enzyme from the oxidoreductase class that catalyzes the conversion of cholesterol to cholest-4-en-3-one and hydrogen peroxide. It can be used in test systems for determining blood cholesterol levels or as a catalyst in the synthesis of biologically active derivatives of cholesterol. This enzyme is obtained only through microbial synthesis, during which the selection of an optimal nutrient medium (NM) in general and the optimal content of the organic nitrogen source, in particular, remains a very relevant issue.

  A Shpachuk , N Ponomarev , E Khryachkova , V Kolodyazhnaya

  494-495

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  EFFECTIVENESS AND SAFETY OF PHYTOTHERAPY OF THE MEDICINAL PLANT - PAPAVER SOMNIFERUM L .) Opium poppy, an annual herbaceous plant, is widely cultivated in southern Central Asia. Its petals contain 0.05% alkaloids and fatty acids. The greatest interest in studying this plant lies in its effects on the nervous system, exhibiting a sedative effect, as well as less pronounced hypnotic and analgesic properties. It is widely known for its hemostatic effect. An infusion made from the petals of the opium poppy is highly valued for its cough suppressant effect. Given its well known beneficial pharmacological effects, the potential for adverse effects of the opium poppy cannot be ruled out.

  K Akhmadjonov , A Azamatov, M Ergasheva

  496

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  FEATURES OF THERAPY WITH HERBAL PRODUCTS OF BELLADONNA (ATROPA BELLADONNA L.) Belladonna , being perennial plant, It is considered widespread throughout Asia Minor. The plant material is harvested primarily in plantations, the leaves during flowering, and the herb during fruit ripening. Belladonna roots are of interest as the primary raw material for therapeutic agents. All parts of the plant are poisonous and contain the alkaloids atropine, scopolamine, and hyoscyamine: 0.14-1.20% in the leaves, 0.2-0.65% in the herb, 0.24-0.6% in the flowers, and 0.7% in the ripe fruit.

  K Akhmadjonov , A Azamatov, M Ergasheva

  497

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  USING THE DIURETIC PROPERTIES OF CUCUMBER ( CUCUMIS SATIVUS L. ) AS A PHYTOTHERAPY FOR KIDNEY DISORDERS Cucumber ( Cucumis ) sativus L. ) contains a significant amount of moisture (90 95% ) , protein (0.8%), sugars (2-2.5%), fat (0.1%), hemicellulose (0.1%), all tissues (0.7%), pectin (0.4%), as well as starch (0.1%) and organic acids. It is rich in vitamins B1, B2, B6, B15, C, PP, as well as microelements K, Ca, Mg, Al, F, Zn, Fe, I.

  K Akhmadjonov , A Azamatov , M Ergasheva

  498-499

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  POLYPHENOLS AS POTENTIAL INHIBITORS OF SARS-COV-2 CORONAVIRUS: AN IN SILICO STUDY Currently, the search for antiviral substances is carried out in two ways: 1. Repurposing existing and screening newly synthesized compounds. 2. Targeted search for natural biologically active substances, in most cases, using computer modeling. The main disadvantage of all currently used drugs is their fairly high toxicity and, as a consequence, the presence of side effects. In the development of new drugs for the treatment of COVID-19, polyphenolic compounds are of particular interest. Studies conducted by scientists from different countries have shown that plant polyphenols are promising polyfunctional compounds with great potential as active ingredients for the creation of new pharmaceutical substances with antiviral activity

  N Abdulladjanova , R Makhmudov, R Rakhimov , U Gayibov

  500-501

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  STUDY OF THE ANTI-INFLAMMATORY ACTIVITY OF THE SUPRAMOLECULAR COMPLEX OF GLYCYRRHIZIC ACID AND RUTIN In leading pharmaceutical companies, the development of new herbal medicines and their application in medical practice has significantly increased. Medicinal plants are of great importance in the global healthcare system due to the effective therapeutic properties of their biologically active components. Currently, phenolic compounds isolated from plants show antioxidant, antihypoxic, antiviral, anti-inflammatory, and vasodilatory activities.

  Q Baratov , G Rakhmonova , N Tagayaliyeva , R Yakubova

  502

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  BIOLOGICAL ACTIVITY OF RIBOSOME-INACTIVATING PROTEINS ISOLATED FROM NIGELLA SATIVA (BLACK SEED) One of the most important directions in the development of new biotechnologies is the creation of pharmacological preparations that have a highly specific effect on cells or molecules in the organism. Currently, proteins or their conjugates are attracting particular interest from researchers in the creation of highly selective drugs. In this context, plant toxins that completely stop protein synthesis in the cell by switching ribosomes to an inactive state are being actively studied. These toxins are collectively called Ribosome-Inactivating Proteins (RIPs).

  B Qoraboyeva , M Oripova , Z Xashimova, Yu Oshepkova

  503-504

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  EFFECTS OF HYALURONIC ACID AND GELATIN-BASED HYDROGELS LOADED WITH DOXORUBICIN ON 4T1 CANCER CELLS Cancer is one of the most life-threatening diseases, and conventional therapies such as chemotherapy, radiotherapy, and systemic treatments are widely used. However, these methods often cause severe side effects, highlighting the need for alternative strategies. Hydrogels, especially those based on hyaluronic acid (HA) and gelatin, are promising due to their biocompatibility, biodegradability, and drug delivery potential. They can release therapeutic agents locally, in a controlled and sustained manner. HA, a natural polysaccharide, combined with gelatin, a collagen derivative, forms hydrogels that interact efficiently with cancer cells, while their water retention and microenvironment support cell regulation. Doxorubicin (DOX), a common chemotherapeutic, inhibits proliferation and induces apoptosis but is limited by systemic toxicity. Therefore, HA–gelatin hydrogels provide an innovative carrier to enhance efficacy and reduce side effects. The 4T1 breast cancer line, known for its aggressive and metastatic behavior, is a suitable model to evaluate these systems. This study examines DOX-loaded HA–gelatin hydrogels on 4T1 cells to provide insights for effective localized cancer therapy.

  A Boydedaev , D Amonova , M Karimov , M Kalonova , B Muhitdinov , A Turaev, Y Huang , H Wang

  505-506

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  ИССЛЕДОВАНИЕ СЕДАТИВНОГО ДЕЙСТВИЯ СУХОГО ЭКСТРАКТА НА ОСНОВЕ МЕСТНОГО ПИОНА ЛЕКАРСТВЕННОГО (PAEÓNIA OFFICINÁLIS L.) С целью создания лекарственных препаратов на основе местного растительного сырья и внедрения их в медицинскую практику необходимо исследование специфической активности разработанных лекарственных препаратов. Методом полиэкстракции получен сухой экстракт, успокаивающего действия, из местного сырья корней и корневищ пиона лекарственного (Paeónia officinális L.).

  Садикова Г. И, Исмоилова Г.М, Зупарова З.А

  507-508

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  STUDY OF THE PHYSICAL AND CHEMICAL PROPERTIES, ANTIOXIDANT AND BIOLOGICAL ACTIVITY OF HUMIC ACIDS OF COALFROM KAZAKHSTAN DEPOSITS OF THE REPUBLIC OF KAZAKHSTAN Currently, Kazakhstan market of medicines is filled with quite expensive antioxidant drugs mainly of foreign production. The country needs domestic medicines and medicinal preparations that can compete with foreign analogues. In this regard, research on the development of innovative import-substituting drugs based on humic substances of peloids are of particular relevance and practical importance. One of the interesting and promising sources of biologically active substances (BAS) in terms of economic and therapeutic efficacy are peloids, in particular, coal, which is a complex of both inorganic and organic substances

  Zh Kairbekov , M Esenalieva , S Suimbaeva , I Dzheldybaeva , A Kairbekov

  509-510

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  ANALYSIS OF STATIONARY CULTIVATION OF THE PASTEUR STRAIN OF RABIES VIRUS Modern production of immunobiological preparations and diagnostic test systems primarily relies on economic efficiency. Traditionally, a stationary cultivation method is used to accumulate virus-containing material, which has a number of advantages associated primarily with the lack of need for expensive equipment , consumables , and greater opportunities for monitoring fungal and bacterial contamination, with low personnel qualifications.

  A Nurmukhambetova , G Ustenova , E Krykbayev , N Akhmetsadykov

  511-512

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