№ 10(MPHAPP) (2025) THE 6TH INTERNATIONAL SCIENTIFIC AND PRACTICAL CONFERENCE “MODERN PHARMACEUTICS: ACTUAL PROBLEMS AND PROSPECTS”

Статьи

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  (1-(4-NITROFENIL)-1H-1,2,3-TRIAZOL-4-IL)METIL 2-GIDROKSIBENZOAT MODDASINING YALLIG‘LANISHGA QARSHI TA’SIRI Bugungi kunda revmatoid artrit va unga o‘xshash surunkali yallig‘lanish kasalliklari butun dunyoda sog‘liqni saqlash tizimi uchun jiddiy muammo bo‘lib qolmoqda. Statistik ma’lumotlarga ko‘ra, revmatoid artrit aholining, ko‘pincha mehnatga layoqatli yoshdagi insonlarning 1–2 % ini qamrab oladi. Ushbu jarayonlar bemorlarning hayot sifatini keskin pasaytiradi, nogironlikka olib kelishi mumkin. So‘nggi yillarda qo‘llanilayotgan nosteroid yallig‘lanishga qarshi dorilar (NYaQD), gormonlar va biologik preparatlar yallig‘lanish jarayonini kamaytirishda samarali bo‘lsa-da, ular ko‘plab nojo‘ya ta’sirlarga ega. Shu bois xavfsizroq va samaraliroq yangi dori vositalarini izlash farmakologiya va tibbiyotda dolzarb masalalardan biri hisoblanadi

  U Aytmuratova , A Azamatov , F Tursunxodjayeva

  547

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  СОВРЕМЕННЫЕ ПОДХОДЫ К ИСПОЛЬЗОВАНИЮ БЕТА- АДРЕНОБЛОКАТОРОВ В ФАРМАКОТЕРАПИИ Сердечно-сосудистые заболевания (ССЗ) продолжают оставаться основной причиной смертности в мире и Республике Казахстан. По данным Всемирной организации здравоохранения, ежегодно от ССЗ умирает более 17,9 млн человек (WHO, 2021). В Казахстане распространенность артериальной гипертензии среди взрослого населения составляет более 25%, что делает проблему её контроля особенно актуальной (Минздрав РК, 2022). Одним из ключевых классов лекарственных средств для лечения ССЗ являются бета- адреноблокаторы (БАБ), которые применяются более 50 лет и занимают важное место в терапии артериальной гипертензии, ишемической болезни сердца (ИБС), хронической сердечной недостаточности (ХСН) и нарушений ритма.

  Молайханов Ш.А, Рахманова Г. М, Рустамханов Д.Р, Шакиров М.А.

  548-549

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  TRANSFORMING PHARMACEUTICAL EDUCATION FOR THE FUTURE: A GLOBAL ASSESSMENT OF SUCCESSES, CHALLENGES, AND EMERGING OPPORTUNITIES Pharmaceutical education plays a crucial role in preparing the next generation of professionals who will shape global healthcare delivery. As the industry faces challenges such as emerging diseases, an aging population, and the integration of advanced technologies, it is essential for educational systems to evolve. Future pharmacists must possess the knowledge, skills, and adaptability to address these issues. This study evaluates current educational reforms and explores how pharmaceutical education systems can better align with emerging healthcare trends, technological advancements, and global health crises. The findings offer valuable insights for educators, policymakers, and industry leaders aiming to modernize pharmaceutical education globally

  Aslam Imran, S Yuldashev

  550-551

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  DEVELOPMENT OF AN EFFERVESCENT TABLET FORM FOR BATHS WITH SOOTHING AND ANTI-INFLAMMATORY EFFECT BASED ON NATURAL RAW MATERIALS In recent decades, there has been a steady increase in the incidence of skin pathologies — allergic dermatitis, eczema, psoriasis, as well as various forms of skin irritation caused by adverse environmental conditions, stress, and reduced immunity. According to dermatological practice, up to 20–30% of the population of different age groups experience manifestations of skin hypersensitivity, accompanied by itching, inflammation, and impaired barrier function. Existing dosage forms (ointments, alcohol-based solutions, creams) have limitations: they may cause burning and discomfort, make it difficult to apply evenly over large skin areas, and reduce treatment adherence. In this regard, there is growing interest in remedies based on natural plant and mineral raw materials, which are characterized by mild action, ecological safety, and ease of use

  A Shaizanda , U Umirzakova , B Torlanova

  552

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  ANALYSIS OF TORASEMIDE BY CHROMATOSPECTROPHOTOMETRIC METHOD Torasemide is a loop diuretic. When used in low doses, its diuresis rate is similar to that of the thiazide group, and the maximum effect is achieved 2 hours after administration. The drug is rapidly and almost completely absorbed into the blood. In patients with impaired liver function, an increase in the concentration of torasemide in the blood plasma is observed. Therefore, such patients should exercise caution. The toxic effect of torasemide can lead to serious complications such as arterial hypotension, confusion, thrombosis, cardiac arrhythmias, angina pectoris and acute myocardial infarction as a result of impaired water and electrolyte balance, increased metabolic alkalosis and excessive diuresis. From the urinary system. In patients with impaired urinary excretion, it can lead to rapid urine output, its retention and overdistension of the bladder. Sometimes the level of uric acid, glucose, lipids in the blood increases.

  N Abdullabekova , Z Usmanalieva

  554-555

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  МЕТОДИКА СУДЕБНО-ХИМИЧЕСКОГО ИССЛЕДОВАНИЯ НЕИЗВЕСТНОЙ ТАБЛЕТКИ С ПОМОЩЬЮ МЕТОДА ИК-СПЕКТРОФОТОМЕТРИИ Неизвестные фармацевтические препараты являются частыми объектами исследования судебно-экспертных учреждений. Неизвестные препараты поступают в виде таблеток, порошка и инъекционных растворов в ампулах, которые обнаруживаются на месте преступления. При этом перед экспертами ставятся задачи по установлению его названия, отнесению к тому-или иному списку наркотических средств и психотропных веществ, подлежащих контролю.

  Абдуллаева М.У, Халилова Н.Ш, Боисходжаева А.А, Сидаметова З.Э

  556-557

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  TOXICITY OF METALS IN VITAL ORGANS OF THE BODY AND THE STUDY OF STRATEGIES FOR ELIMINATING THEIR TOXINS FROM THE PERSPECTIVE OF RHAZES AND AVICENNA In recent decades, due to the expansion of the consumption of processed foods, the increase in environmental pollutants, and the decline in nutritional quality, the possibility of poisoning with some metals found in foods, such as lead and mercury, has increased. These metals can negatively affect vital organs of the body, such as the brain, heart, and liver, disrupting their function. The present study aimed to investigate how metal toxicity occurs in vital organs of the body and analyze the therapeutic strategies for eliminating their toxins from the perspectives of Rhazes and Avicenna in two valuable books, Al-Hawi fi al-Tibb and Al-Qanun fi alTibb

  Mohammad Hashemimehr

  558

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  ANALYSIS OF TOXIC METALS IN DAIRY PRODUCTS USING THE VOLTAMMETRY METHOD Dairy products are widely consumed by humans and represent an important source of proteins, fats, and minerals for the body. Unfortunately, due to environmental pollution, these products may also contain toxic metals along with other harmful substances. The accumulation of toxic metals in dairy products at elevated levels poses a serious threat to food safety and human health. Therefore, determining the amount of toxic metals in dairy products is of great importance. In this study, the contents of toxic metals such as lead (Pb) and cadmium (Cd) in certain dairy products were determined using voltammetry, and the results were compared with the permissible hygienic limits

  Z Asrorova , Z Yaxshieva

  559

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  РАЗРАБОТКА МЕТОДИКИ ХИМИКО-ТОКСИКОЛОГИЧЕСКОГО ИССЛЕДОВАНИЯ МАЛЫХ КОЛИЧЕСТВ НЕКОТОРЫХ ПРЕКУРСОРОВ С ИСПОЛЬЗОВАНИЕМ ИК-СПЕКТРОФОТОМЕТРИИ Прекурсоры – вещества(уксусный ангидрид, эфедрин, псевдоэфедрин, кислоты, растворители), которые используются при производстве, изготовлении, переработке наркотических средств и психотропных веществ с целью получения более сильнодействующих наркотиков (ацетилированный опий, героин, метамфетамин, ЛСД). Так, эфедрин, псевдоэфедрин могут применяться для приготовления в кустарных условиях наркотического средства - психостимулятора метамфетамина (первитина).

  Абдуллаева М.У, Халилова Н.Ш, Олимов Н.К

  560-561

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  COMPOSITION OF VARIOUS HEMATOGEN PREPARATIONS AND THE TOXIC EFFECTS OF THEIR COMPONENTS ON THE HUMAN BODY One of the most common health issues observed among the population today is iron deficiency. According to the World Health Organization (WHO), in 2023, anemia was diagnosed in 2.24 billion people worldwide, and this number continues to increase daily. In Uzbekistan, anemia has been recorded in 17.5% of men and 31.2% of women. Iron deficiency raises the demand for ironcontaining preparations, which necessitates their production. Currently, the pharmaceutical market offers various types of iron-containing medicines. These preparations are based on iron (Ferrum), but they differ in their main and excipient components, as well as in their dosage forms—such as tablets, syrups, injections, biologically active supplements, and food-like products such as bars known as hematogen. Hematogen lat. Haematogenum in greek αἷμα (blood) and γένος (generation).

  Sh Muzaffarova , M Xamdamov , M Nurmatova

  562

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