Evaluation of the sensitivity of microflora of the periodontal pocket to antibacterial agents in the conditions of the rural population

Relevance of the topic: the use of antibiotics after surgery in the treatment of periodontal  disease  is  aimed  at  eliminating  the  pathogenic  microflora  of  the periodontium,  oral  cavity  and  restoring  the  normal  microbiota,  which  is  inherent  in healthy  periodontal  tissues.  We  know  that  periodontal  diseases  are  caused  by periodontal  pathogens:  Porphyromonas  gingivalis. Actinobacillus  actinomycetemcommitans  ,Bacteroides  forsithus,  Threponema denticola , Prevotella intermedia, Actinomices viscosus. Numerous studies suggest that the  role  of  polymicrobial  synergy  in  the  development  of  dental  diseases.  When prescribing antibacterial drugs, the doctor should remember that most microorganisms of the oral cavity are combined into a microbial biofilm. Microorganisms of the oral cavity  form  a  microbial  biofilm  on  the  surface  of  the  teeth  –  a  special  form  of organization  of  microorganisms,  which  is  surrounded  by  a  protective  matrix  –  a complex of glycosaminoglycans and proteins. It is this protective matrix that does not allow antibacterial drugs from saliva or gingival fluid to penetrate inside the biofilm. Therefore,  microorganisms  in  the  biofilm  are  more  resistant  to  antibiotics, antimicrobials and other active agents. The most effective choice for the treatment of infectious and inflammatory processes of the oral cavity should be based on the results of  modern  scientific  research,  proving  the  clinical  and  microbiological  efficacy  and safety of any drugs.