КЛИНИЧЕСКИЕ ИССЛЕДОВАНИЯ
2.
ЛИТЕРАТУРА/REFERENCES
Гопурова ГФ. Ўткир полиморф психотик бу-
зилишларнинг
клиникиммунологик
бузили-
шлари/ Султанов Ш.Х., Курбаниязова Ш.Э.
«NEVROLOGIYA
»—2(82).
"Ташкент
2020.
стр. 62-64. [Gopurova G.F. O'tkir polimorf
psixotik
buzilishlaming
klinikimmunologik
huzilishlari
Sultanov
Sh.X..
Kurbanivazova
Sh.E. «NEVROLOGIYA »—2(82), Tashkent 2020. str.
62-64.]
Нарходжаев А. А.. Гофурова Г.Ф., Султа
нов LUX. Алкоголга царам бўлган беморлар-
да
вахима
бузилишларининг
уусусиятла-
ри/« NEVROLOGIYA»—2(82), Ташкент2020, стр.
53-55. [Narxodjaev A.A., Gofurova G.E, Sultanov
Sh.X. Alkogolga qaram bo 'lgan bemorlarda vaxima
buzilishlarining hususiyatlari ■■ NEl ROLOl И
YA»—2(82), Tashkent 2020, str. 53-55.]
Гопурова ГФ. Реакция иммунной системы на
острый полиморфный психоз/ Ходжаева НИ,
Султанов Ш.Х. Инфекция, иммунитет и фарма
кология-2020, № 3, стр. 39-43. [ Gopurova G.E,
Xodjaeva N.I, Sultanov Sh.X. reaktsiya immunnoy
sistemi na ostriy polimorfhiy psixoz Infektsiya,
immunitet i farmakologiya]
Nikitina, V. Role of immune mechanisms information
of variants of adaptation in persons with PTSD / V.
Nikitina, T. Vetlugina, E. Epan-chintseva, V. Semke
/// European Psvchiatrv. - 2010. - Vol. 25. -Suppl.
1.-P.833.
Черенъко, В. Б. Система иммунитета при раз
ных уровнях психических расстройств / Т. И.
Ветлугина, С. А. Иванова, О. А. Никифорова, В.
Б. Черенъко II Сибирский вестник психиатрии и
наркологии. -1996. -№ 2.
6.
- С.
77—
78. [Cherenbko, V. В. Sistema immuniteta
pri raznix urovnyax psixicheskix rasstroystv / T.
P. Vetlugina, S. A. Ivanova, 0. A. Nikiforova, V. B.
Cherenbko II Sibirskiv vestnikpsixiatrii i narkologii.
-1996.-N° 2. -S. 77— 78]
7.
Никитина ВБ. Иммунокоррекция и и иммуно
реабилитация при психических расстройствах
Ветлугина Т.П., Иванова о.А., Лобачева В.Б.,
Лебедева ВБ. II Метаболические механизмы
иммунореактивности. Красноярск 2004, Стр.
107-108. [Nikitina V.B. Immunokorrektsiya i i
immunoreabilitatsiya pri psixicheskix rasstroystvax
/ Vetlugina TP, Ivanova o.A„ Lobacheva VB„
Lebedeva
VB.
II
Metabollcheskie
mexanizmi
immunoreaktivnosti. Krasnoyarsk 2004, Str. 107-108.]
8.
Никитина ВБ. Состояние иммунитета у боль
ных с впервые диагностированной шизофренией
//Ж. невропатолог и психиатрии. -1991,-№ 8,-
Стр. 47-49. [Nikitina V.B. Sostoyanie immuniteta и
Ьо1ъпых s vpervbie diagnostirovannoy shizofreniey //
J. nevropatolog ipsixiatrii. -1991,-№ 8,-Str. 47-49.]
9. Lyall, M- Systematic review, and: critical evaluation
of the immunology> of chronic fatigue syndrome /М:
LvalEM: Peakman, Si A. Wessely//JPsvchosomRes:
-2003: -Vol: 55: №2: -P: 79-90:''
10. Marquesr A: H. Brain-immune interactions and
implications psychiatric disorders / A: H: Marques;
G'. Cizza, E. Sternberg:// Rev. Bras. Psiquiatr.
-2007.-№29: -Suppl.l.-S: 27-32:
11. Impairedmatural immunity, cognitive dysfunction, and,
physical symptoms in patients with; chronic; fatigue
swdrome: preliminary>: evidence for a?sub-group
7
/ Si I): Siegel, M: H: Antoni, Ml. A. Fletcher etal: II
. -2006: - Vol:60iN6: -P: 559-566:
УДК: 616.36-002.2:616.314-089.87:332.143
MONITORING THE INCIDENCE OF INFLAMMATORY
PROCESSES OF MALE AFTER TOOTH EXTRACTION
IN PATIENTS WITH CHRONIC HEPATITIS
Rakhmatullaeva O. U., Shomurodov K.E.
Tashkent State Dental Institute
ABSTRACT
As a result of numerous clinical and experimental
studies, a relationship has been established between
changes in the oral cavity and pathology of internal
organs. In modem dentistry, interest in research
on concomitant pathologies is explained by the
accumulation of new arguments, the emergence of
new information in the system of the whole organism
[3,5]. This analysis focuses on the prevalence of
hepatitis infection and its various oral manifestations,
consequences and clinical course. In this regard, the
monitoring of outpatient records of patients with
concomitant pathology, such as hepatitis А, В, C
with inflammatory processes of the oral cavity and
maxillofacial area after tooth extraction for emergency
indications in the clinic of surgical dentistry of the
clinic of the Tashkent State Dental Institute over the
past 5 years was carried out.
Relevance. Diseases of internal organs, in particular
the liver and organs of the oral cavity. The development
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КЛИНИЧЕСКИЕ ИССЛЕДОВАНИЯ
of lesions of the mucous membrane and inflammatory
diseases of the periapical tissues of the oral cavity (in
particular, complications arising after tooth extraction)
aggravate the course of the underlying disease and
represent the particularities of carrying out therapeutic
and preventive measures [4,5].
The study of the oral cavity in liver diseases is of
interest to physicians [7], since the disease processes
developing in the liver mainly provoke organic
and functional disorders in the oral mucosa and
periodontium [1].
It should be noted that the incidence of viral hepatitis
has sharply increased in large cities of our Republic.
As for the incidence of viral hepatitis, in this regard,
a tense epidemiological situation has also developed
in Uzbekistan, with a steady upward trend, especially
in recent years. In the structure of the registered
morbidity, adolescents and young people generally
occupy an important place (80%). [3]
Most deaths are currently associated with viral
hepatitis (this infection ranks second among the causes
of death of people from infectious diseases) and most of
the cases of chronic liver diseases, including cirrhosis
and primary liver cancer [6]. Dental care for patients,
even with an established diagnosis of hepatitis, is
provided mainly on the basis of accessibility due to
acute pain. There are very few developments in the
dental tactics of managing patients with hepatitis. In
countries with a high level of dental services, there is
also no experience on this problem. The widespread
occurrence of viral hepatitis, in particular hepatitis B,
requires in-depth dental research. [1,7].
Purpose of the study.
Conducting outpatient
follow-up of patients with concomitant pathology,
for example, chronic hepatitis with inflammatory
processes of the oral cavity and maxillofacial region
after tooth extraction for urgent indications in the
clinic of surgical dentistry of the clinic of the Tashkent
State Dental Institute over the past 5 years.
MATERIALSAND RESEARCH METHODS
According to archival data for 5 years on the
basis of the clinic of adult surgical dentistry of the
Tashkent State Dental Institute, an analysis of 78 case
histories of hospitalized patients with hepatitis and
107 outpatient records of patients with concomitant
pathologies such as hepatitis А, В, C aged 25 to 65
years with various types of odontogenic inflammatory
processes
of
the
oral
cavity
and
maxillofacial
region. [1] Statistical analysis of case histories and
outpatient charts was carried out depending on the
type of hepatitis, as well as inflammatory processes
of the maxillofacial area of different localizations
with different courses.
Distribution of hepatitis by complications in the
form of inflammatory processes of various localization.
Table 1
Complications
Hepatitis
Alveolitis
phlegmon
of the
maxillofacial
region
(different
localization)
Periostitis
Lymphadenitis
A
10
3
7
2
В
8
5
10
4
C
3
1
3
1
Total
26
17
24
11
%
33
22
31
14
According to table 1, within 5 years from the
histories of diseases with odontogenic phlegmons of
the maxillofacial area of various localization, which
have concomitant pathology, such as hepatitis (A, B,
C) amounted to 17 (22%) patients; with lymphadenitis
in 11 (14%), periostitis in 24 (31%), alveolitis in 26
(33%) patients.
Consequently, due to the existence of a close
functional connection between the affected organs,
the dependent course of the disease is characteristic
of combined pathology. In this case, the concomitant
pathology of hepatitis is of interest in this regard. From
the monitoring carried out, it should be noted that
inflammatory processes in the oral cavity aggravate
the course of the disease and serve as an important
addition to the characteristics of the general picture of
hepatitis. With the concomitant pathology of hepatitis,
a large number of complications in the form of
alveolitis 21 (36.8%) and periostitis 20 (35.2%) were
revealed.
It is known that in chronic liver diseases secondary
immunodeficiency is formed, which is of great
importance for the oral cavity and the whole organism,
therefore, the importance of the problem of studying
the course of inflammatory processes in the oral cavity
in patients with liver pathology, which requires timely
and constant correction, becomes clear. It should also
be noted the persistence of various microorganisms
in
saliva,
which,
under
certain
conditions
and
secondary immunodeficiency in the div, can give
rise to pathogenic flora that contributes to the lesion
of the periodontium. The state and diseases of the oral
cavity should be considered dependent not only on the
microbial factor, but also as a result of the state of the
organism as a whole. [3,8].
Conclusion.
Studying the history of the disease
and diseases of the oral cavity of patients of different
subgroups of observation with somatic pathology, it is
possible to draw a conclusion about the dependence
on the presence or absence of somatic problems.
Patients
with
concomitant
pathology,
namely
chronic hepatitis, have poor quality of health of teeth
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КЛИНИЧЕСКИЕ ИССЛЕДОВАНИЯ
and gums in the oral cavity when compared with the
somatically healthy study group. This fact indicates
the effect of liver disease on the condition of the teeth
of the mouth in general.
Patients with hepatitis, the structure of dental
problems is determined by the phase of therapy of the
underlying problem, and also requires additional and
further study.
ЛИТЕРАТУРА/REFERENCES
1.
Алейник, М.Д.0 результатах оценки риска
заражения гепатитом В медицинских ра
ботников Нижегородской области и путях
его снижения: справочная информация / М.Д.
Алейник. Н. Новгород, 2008. [Aleinik, M.D.
On the results of assessing the risk of hepatitis
В infection of medical workers in the Nizhny
Novgorod region and ways to reduce it: reference
/M.D. Aleinik. N. Novgorod 2008.].
2.
Akhrorova Z.K. Features of the lesion of the oral
mucosa and periodontal disease in patients with
chronic liver diseases of viral etiology> / Z.K.
Rakhmonova // Aviation abstract of Ph.D. thesis
2011. [Ахророва 3.K. Особенности поражения
слизистой оболочки полости рта и пародонта
у больных хроническими заболеваниями печени
вирусной этиологии / З.К. Рахмонова // авто
реферат канд. диссертация, 2011 ].
3.
Roda Rafael Poveda , Med Oral Patol Oral Cir
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4.
Rupasova A.R., Sorokina A.Yu. VIRAL HEPATITIS
// International student scientific bulletin.-2018.
No 4-2.:
5.
Treatment
of
inflammatory>
and
atrophic
complications after tooth extraction / SV Sirac,
AD. Chitanava, AG. Sirac, K.H. Kardanova, MA.
Sasina Materials of the XVIIIfinal (interregional)
scientific
conference
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6.
Young КС., Chang T.T., Liou T.C., Wu H.L.
Detection of hepatitis C virus RNA in peripheral
blood mononuclear cells and in saliva. //J. Med.
Virol. 2013 Sep. -vol. 41 (l).-P. 55-60.
7.
Zmuda J.F, Wagoneer B., Liotta L., Whiteley G.
Recognition of multiple classes of hepatitis C
antibodies increases detection sensitivity> in oral
fluid. //Clin. Diagn. Lab. Immunol. 2011. - N 8. -
P. 1267-70.
8.
Krasteva A., Panov VI, Garova M., Velikova R.,
Kisselova A., Krastev Z. Hepatitis В and C in
dentistry>. JIMAB 2008: 2: 38-40
9.
7. RakhmonovKh.Sh. The role ofbarrier-protective
complexes of the oral cavity> at pathology of hard
tissues of teeth and the way of their correction
Abstract of the dissertation of the doctor med.
Sciences Tashkent, 2003.
УДК: 616.314.001.6-007-089.843]-616.31-008.9
СОСТОЯНИЕ МЕТАБОЛИЧЕСКОЙ СИСТЕМЫ
ПОЛОСТИ РТА ПОСЛЕ ЛЕЧЕНИЯ С ИСПОЛЬЗОВАНИЕМ
ДЕНТАЛЬНОЙ ИМПЛАНТАЦИИ
С.Ч. Сафарова
Ташкентский государственный стоматологический институт
Цель: В
стоматологической практике большой ин
терес для изучения представляет ротовая жидкость
(РЖ). РЖ является биологической средой, которая
омывает всю полость рта, взаимодействуя со слизи
стыми, зубами и ортопедическими конструкциями.
Ротовая жидкость оказывает влияние на все компо
ненты зубочелюстной системы, с которыми контак
тирует, являясь для них агрессивной средой, спо
собной изменять их физико-химические показатели.
Новые компоненты зубочелюстной системы способ
ны изменять состав ротовой жидкости, что актуали
зирует использование ее биохимического исследова
ния для определения звеньев патогенеза заболеваний
полости рта на молекулярном уровне и обоснования
возможностей их метаболической коррекции. Так
на изменение ферментативной активности ротовой
жидкости могут влиять ионы металлов используе
мых для изготовления дентальных имплантатов и
их ортопедических составляющих, что может приво
дить к изменению защитных, минерализующих, пи
щеварительных и других свойств, что может пагубно
влиять как на зубочелюстную систему, так и на весь
организм в целом.
Ключевые слова/keywords: ПОЛ, АОС, полости
рта, адентии . POL ,AOS cavity,adentias
Материал и методы:
Сегодня внутрикостные
имплантаты все чаще внедряются в широкую
стоматологическую практику. Разнообразные си
стемы имплантатов стали доступны для повсед
невной хирургической стоматологии в конце 30-х
годов. Имплантаты представляют собой альтерна
тивный метод лечения различных видов адентий.
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