Profilaktik tibbiyot va salomatlik
–
Профилактическая
медицина
и
здоровье
–
Preventive Medicine
and Health
Journal home page:
https://inscience.uz/index.php/preventive-medicine
Introduction into the practice of medical ozone in
combination with antiviral drugs for the treatment of
women with herpes infection on the background of FPI
Khayitkhon ABDURASHIDOVA
Andijan State Medical Institute
ARTICLE INFO
ABSTRACT
Article history:
Received August 2023
Received in revised form
10 September 2023
Accepted 25 September 2023
Available online
15 October 2023
Herpetic infection caused by the herpes simplex virus (HSV)
is one of the significant problems of modern health care. This is
due to a sharp increase in the incidence, a wide range of clinical
manifestations, the possibility of an asymptomatic course and a
high contagiousness of the pathogen. The probability of
intrauterine transmission of HSV, which significantly worsens
perinatal outcomes, has been proven. Over 90% of people in the
world are infected with HSV, and only 20% of it manifests itself
clinically.
2181-3663
/©
2023 in Science LLC.
https://doi.org/10.47689/2181-3663-vol2-iss5-pp32
This is an open-access article under the Attribution 4.0 International
(CC BY 4.0) license (
https://creativecommons.org/licenses/by/4.0/deed.ru
Keywords:
herpes infection,
ozone therapy,
miscarriage.
Ayollarning FPY fonidagi gerpes virus infeksiyasini
davolash maqsadida tibbiy ozonni antivirus dorilar bilan
birga amaliyotga tatbiq etish
ANNOTATSIYA
Kalit so‘zlar
:
gerpes infeksiyasi,
ozon terapiyasi,
abort.
Herpes simplex virusi (HSV) keltirib chiqaradigan herpetik
infeksiya hozirgi kunda sog‘liqni saqlashning muhim
muammolaridan biri hisoblanadi. Bu kasallanishning keskin
o‘sishi, klinik ko‘rinishlarning keng doirasi, asiptomatik ko‘rinish
ehtimoli va patogenning yuqori yuqumliligi bilan bog‘liq.
Perinatal
natijalarni sezilarli darajada yomonlashtiradigan HSVning
intrauterin yuqishi ehtimoli isbotlangan. Dunyodagi odamlarning
90% dan ortig‘i HSV bilan kasallangan va uning faqat 20% klinik
ko‘rinishda namoyon bo‘ladi.
1
Resident of the magistracy of the 3rd course of the Department 1-Obstetrics and Gynecology, Andijan State Medical
Institute. Andijan, Uzbekistan.
2
Candidate of Medical Sciences, Associate Professor, Department 1-Obstetrics and Gynecology, Andijan State
Medical Institute. Andijan, Uzbekistan.
Profilaktik tibbiyot va salomatlik
–
Профилактическая медицина и здоровье
–
Preventive Medicine and Health
Issue
–
2
№
5 (2023) / ISSN 2181-3663
33
Внедрение в практику медицинского озона в
комбинации с противовирусными препаратами для
лечения женщин с герпесной инфекцией на фоне ФПН
АННОТАЦИЯ
Ключевые слова:
герпетическая инфекция,
озонотерапия,
аборт.
Герпетическая инфекция, вызванная вирусом простого
герпеса (ВПГ), является одной из важных проблем
современного здравоохранения. Это связано с резким
ростом заболеваемости, широким спектром клинических
проявлений, возможностью бессимптомного течения,
высокой
инфекционностью
возбудителя.
Доказана
возможность
внутриутробной
передачи
ВПГ,
что
значительно ухудшает перинатальные исходы. Более 90%
людей в мире инфицированы ВПГ, и только у 20% он
проявляется клинически.
The purpose of the research is to study the effectiveness of the use of medical
ozone in the complex of prevention and treatment of FPI in pregnant women with herpes
infection. The basis of treatment is the early initiation of systemic antiviral therapy.
The minimum recommended duration of treatment is 5 days, with a primary episode
–
7-10 days. Therapy reduces the duration of the disease and is indicated in all cases, even
with a mild course.
Recommended treatment regimens for a primary episode of HSV:
• acyclovir 200 mg 5 times or 400 mg 3 times a day for 7
-10 days;
• valaciclovir 500 mg 2 times a day for 7
-10 days;
• famciclovir 250 mg 3 times a day for 7
-10 days.
The effectiveness of suppressive therapy has been proven in a multicenter open
study involving 75 patients, during which the use of valacyclovir was evaluated for
episodic (500 mg 2 times a day for 5 days) and continuous treatment (500 mg per day
continuously). The results showed that the likelihood of recurrence of genital herpes was
reduced by 78% in patients who received a course of suppressive therapy. In recent
years, parenteral ozone therapy has been increasingly used in the treatment of various
diseases.
Fundamental biochemical, immunological, morphological, ultrastructural,
physiological studies and clinical trials of parenteral use of ozonized solutions indicate
high efficiency in activating the microsomal system of the liver, optimizing the
antioxidant activity of the div. Thus, it becomes possible to use ozone in clinical
toxicology in the toxicogenic and somatogenic stages, as a powerful antihypoxic and
antioxidant agent. Ozone (Oz) is an allotropic form of oxygen, a gas with a pungent
characteristic odor. Ozone is a much stronger oxidizing agent than oxygen.
In this regard, ozone oxidizes many substances that are inert to oxygen under
normal conditions. Characteristic products of a number of chemical reactions of ozone
are ozonides, which are formed during the reaction of ozone with C=C bonds. Numerous
studies have shown that therapeutic doses of ozone stimulate the antioxidant system and
reduce the intensity of lipid peroxidation (LPO). In the process of ozone therapy, the
Profilaktik tibbiyot va salomatlik
–
Профилактическая медицина и здоровье
–
Preventive Medicine and Health
Issue
–
2
№
5 (2023) / ISSN 2181-3663
34
initial activation of free radical oxidation under the influence of ozone therapy naturally
occurs, since ozone, oxygen, and free radicals are introduced into the div, but at the
same time, the antioxidant system (AOS) is quickly launched, which ozone indirectly
stimulates.
Regulation of LPO and AOS processes in the div, apparently, is one of the
mechanisms of the therapeutic effect of ozone therapy. At the same time, many authors
consider LPO activation to be one of the universal pathogenetic factors in various
diseases. The pathogenetic expediency of using medical ozone (correcting
uteroplacental-fetal blood flow, improving hemorheological properties of blood, immune
and biochemical parameters of homeostasis of a pregnant woman) fully extends to the
newborn, whose adaptive capabilities increase significantly.
MATERIAL AND METHODS
We have examined and treated 74 women with threatened miscarriage in the first
trimester, aged 19 to 34 years. Of these, 47 patients made up the main group, who were
treated with medical ozone in the complex of therapeutic measures, and 27 patients
made up the control group, who were treated with traditional methods. A thorough
analysis of the clinical characteristics of patients showed that most of them have a
combination of several factors of miscarriage (infectious-inflammatory, hormonal,
immunological, etc.), which makes it difficult to distinguish groups of patients in
accordance with the etiology of the disease.
The medical ozone therapy unit
“
Medozon
”
was used as the hardware for ozone
therapy. A parenteral drip injection of 0.9% ozonized sodium chloride solution with an
ozone concentration of 2-3
μ
g/ml was carried out at a rate of 30 drops for the first 5
minutes and then 40-50 drops per minute. For the first 5 days, ozone therapy was carried
out every other day, then 2 times a week (6-8 procedures in total for the course of
treatment). To evaluate the effectiveness of treatment of pregnant women with the threat
of miscarriage, the following clinical criteria were taken into account: complaints, the
intensity of pain syndrome, gynecological examination data, and pathological discharge
from the genital tract.
Changes in hematological, immunological, biochemical, microbiological and
instrumental research methods were evaluated.
CONCLUSION
Thus, FPI largely determines the condition of the newborn, increasing the
frequency of various complications, mainly associated with an insufficient supply of
oxygen and nutrients to the fetus through the placenta.
At the same time, the use of medical ozone as part of the complex therapy of
FPI helps to reduce the severity of such manifestations, bringing it closer to the average
population. Herpes infection is an extremely common sexually transmitted disease
characterized by a relapsing lifelong course. Conducting oral antiviral therapy
significantly reduces the duration, and severity of the disease and the risk of infection of
the sexual partner.
The most frequent appointment of valaciclovir is justified by the lower frequency
of use of the drug and its high bioavailability. The use of valaciclovir and medical ozone in
combination in women with herpes infection against the background of FPI, in whose
anamnesis there were cases of miscarriage, gave a good result in practice.
Profilaktik tibbiyot va salomatlik
–
Профилактическая медицина и здоровье
–
Preventive Medicine and Health
Issue
–
2
№
5 (2023) / ISSN 2181-3663
35
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