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BACTERIAL COINFECTION AND SECONDARY INFECTION IN
COVID-19 PATIENTS
Abduvohidova Z.Sh. II-Pediatric and medical-biological faculty group 510
Scientific adviser: Associate dosent Ibragimova X.N.
Department: TashPMI, Infectious diseases, childhood infectious diseases,
phthisiology and pulmonology
Bacterial copathogens are commonly found in viral respiratory infections and are important causes
of morbidity and mortality. The prevalence of bacterial infection in patients infected with SARS-CoV-2
is not well understood.
Objective:
To determine the prevalence of bacterial coinfection (at admission) and secondary
infection (after admission) in patients with COVID-19.
Methodology:
We conducted a collection analysis to determine the prevalence of respiratory
bacterial infections among individuals with confirmed active COVID-19 infection. We included studies
of people with laboratory-confirmed SARS-CoV-2 infection at Zangiota Hospital No. 1. 50 children were
examined. Bacterial infection was defined as an acute infection,
including either co-infection on admission or secondary infection occurring during illness or hospital
stay.
We included randomized controlled trials, cohort studies, and case series with more than 10
patients, but excluded reviews, editorials, letters, and case studies. We considered studies to be
appropriate regardless of experimental or observational design and regardless of their primary purpose.
However, we excluded studies that did not report bacterial infection or only reported chronic co-infection
or non-bacterial pathogens.
Results:
Data were extracted by one reviewer and cross-checked by a second reviewer. The
primary outcome was the proportion of COVID-19 patients with acute bacterial infection. Any bacteria
not found in the respiratory tract or in the bloodstream were excluded. Of the 1,308 studies reviewed, 24
were eligible and included in a rapid review of 3,338 COVID-19 patients screened for acute bacterial
infection. In a meta-analysis, bacterial coinfection (score at admission) was found in 3.5% of patients
(95% CI 0.4-6.7%) and secondary bacterial infection in 14.3% of patients (95% CI 9.6-18, 9%). The
overall proportion of patients with COVID-19 with a bacterial infection was 6.9% (95% CI 4.3-9.5%).
Bacterial infection was more common in critically ill patients (8.1%, 95% CI 2.3-13.8%).
Conclusions:
Bacterial coinfection is relatively rare in hospitalized patients with COVID-19. Most
of these patients may not require empiric antibiotic therapy.
References:
1.
Mirzayeva, U., and H. Nasirova. "METABOLIC DISORDERS IN THE ACUTE PERIOD OF
COVID-19." Science and innovation 2.D7 (2023): 10-17.
2.
Мирзаева, У. З., С. И. Исмаилов, and Х. К. Насырова. "НАРУШЕНИЕ УГЛЕВОДНОГО
ОБМЕНА У ПАЦИЕНТОВ COVID-19." BARQARORLIK VA YETAKCHI TADQIQOTLAR
ONLAYN ILMIY JURNALI 2.9 (2022): 117-122.
3.
Nasirova, Khurshida, and Sitorakhon Muminova. "Management of pregnant women with
prolactinomas and analysis of their pregnancy outcomes." Endocrine Abstracts. Vol. 70.
Bioscientifica, 2020.
