Experience Of Application Of A New Hemostatic Agent "Gemogubka" In The Prevention Of Bleeding From The Gall Bladder Body After Traditional Cholecystectomy

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O.U. Rakhimov, . (2021). Experience Of Application Of A New Hemostatic Agent "Gemogubka" In The Prevention Of Bleeding From The Gall Bladder Body After Traditional Cholecystectomy. The American Journal of Medical Sciences and Pharmaceutical Research, 3(03), 122–131. https://doi.org/10.37547/TAJMSPR/Volume03Issue03-18
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Abstract

Purpose of the study. To assess the effectiveness of the use of hemostatic agent "GEMOGUBKA" for the prevention of bleeding from the bed of the gallbladder during traditional cholecystectomy. Methods. The study included 88 patients operated for acute calculous cholecystitis. Depending on the method of bleeding hemostasis, all patients were divided into 2 groups: in the study group (n=43), after cholecystectomy, 250-300 mg of "GEMOGUBKA" in the form of a fine powder was applied to the gallbladder bed for hemostasis; in the control group (n=45), after cholecystectomy, hemostasis was carried out by electrocoagulation of the gallbladder bed with a monopolar electrode. All patients in the postoperative period underwent control-dynamic ultrasound examination, study of the volume and nature of the discharge from the drains, as well as a biochemical blood tests. Results. In the study group, the average duration of hemostasis with bleeding from the bladder bed was 2,3±1,3 minutes, which is almost 2 times less than in the control group - 4,2±1,5 minutes. The duration of bed-days after surgery was 4,5±0,78 days and 6,3±2,06 days, respectively. The duration of the presence of the drainage tubes in the abdominal cavity in the study group was 1,49±0,88 days, while in the control group it was 4,24±1,38 days. The dynamics of the manifestation of cytolytic syndrome showed a low degree of intraoperative aggression during hemostasis in the study group, which significantly differed from the high rates of cytolysis in the control group. In the study group of patients, it was possible to significantly reduce the proportion of serous-hemorrhagic and hemorrhagic discharge from the drainage tube in comparison with patients in the control group. Conclusion. The use of the biocomposition in the form of the hemostatic drug "GEMOGUBKA" allowed both to reduce the duration of bleeding from the bed of the gallbladder, and the incidence of local inflammatory complications of the surgical site during traditional cholecystectomy.

 

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References

Davydov A.A. The influence of electroexcision of the gallbladder on the course of the postoperative period and the functional state of the liver. 2002;2:34-38. (In Russ.)

Plotkin A.V., Poskrovskij E.Zh., Voronova G.V. i dr. Evaluation of the effectiveness of the hemostatic action of the drug "Hemoblock" in cavity and laparoscopic interventions. Mul'ticentrovye klinicheskie issledovanija. Vestnik sovremennoj klinicheskoj mediciny. 2015;8:56-61. (In Russ.)

Rahimov O.U., Muhammadsolih Sh.B. Surgical treatment of intra-abdominal bleeding after cholecystectomy, innovative technologies in medicine: a view of a young specialist. Materialy V Vserossijskoj nauchnoj konferencii molodyh specialistov, aspirantov, ordinatorov. 2019:69-70. (In Russ.)

Rahimov O.U., Tursumetov A.A., Zhamalov Zh.B. Intra-abdominal bleeding after various cholecystectomy options. Evrazijskij vestnik pediatrii. 2019;3:224-229. (In Russ.)

Sadykov R.A., Ismailov B.A., Kim O.V. NNew film coating made from cellulose derivatives for local hemostasis. Novosti hirurgii. 2019;3:256-261. (In Russ.)

Tarkova A.R., Chernjavskij A.M., Morozov S.V. Local hemostatic material based on oxidized cellulose. Sibirskij nauchnyj medicinskij zhurnal. 2015;2:15-19. (In Russ.)

Cheng W., He J., Wu Y. et al. Preparation and characterization of oxidized regenerated cellulose film for hemostasis and the effect of blood on its surface. Cellulose. 2013;20(5):2547–2558. https://doi.org/10.1007/s10570-013-0005-5

Brustia R., Granger B., Scatton O. An update on topical haemostatic agents in liver surgery: systematic review and metaanalysis. Journal оf Hepato‐Biliary‐Pancreatic Sciences. 2016;10(23):609-621. https://doi.org/10.1002/jhbp.389

Mueller G.R., PinedaT.J., XieH.X. et al. A novel sponge-based wound stasis dressing to treat lethal noncompressible hemorrhage. J. Trauma. 2012;73(Suppl. 1):134-139. https://doi.org/10.1097/ta.0b013e3182617c3c

Aday U. The effects of low-molecular-weight-heparin administration on bleeding in elective laparoscopic cholecystectomy. Laparoscopic Endoscopic Surgical Science [Internet]. Kare Publishing; 2018; Available from: https://doi.org/10.14744/less.2017.53215

Szoka N, Yoo J. Use of Mini-Laparoscopic Percutaneous Graspers During Laparoscopic Cholecystectomy. CSurgeries [Internet]. CSurgeries; 2017 Jun; Available from: https://doi.org/10.17797/201706072

Thakur S. Bleeding complications in laparoscopic cholecystectomy: Incidence, mechanisms, prevention and management. Journal of Minimal Access Surgery [Internet]. Medknow; 2011;7(3):200. Available from: https://doi.org/10.4103/0972-9941.83516

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