THE ROLE OF MELATONIN IN DIABETIC PATIENTS
Keywords:
Abstract
Diabetes mellitus (DM) and complications associated with diabetes are one of the leading causes of death worldwide. The International Diabetes Federation (IDF) has estimated that 592 million people will suffer from diabetes by 2035. Therefore, it is vital to find a new biomolecule that can further help in the treatment of diabetes. For several decades, a persistent interest in the biological properties of melatonin (MT) has been maintained in biological science and medicine. In recent years, a lot of information has appeared about its participation in maintaining energy homeostasis and the genesis of diabetes mellitus. The purpose of this review is to study the pathogenetic mechanism of melatonin in diabetes mellitus
Similar Articles
-
PRESCRIPTION PERILS: SAFEGUARDING PATIENT WELFARE THROUGH ENHANCED ELECTRONIC PRESCRIBING PROTOCOLS IN PRIMARY HEALTH CARE
-
Clinical And Functional Changes In Hard Tissues Of Teeth In Patients With Hemophilia
The American Journal of Medical Sciences and Pharmaceutical Research: No. 12 (2020) / Alisher Berdikulovich Norbutaev, Mukhiddin Kamariddinovich Shamsiev, Nodira Sharipovna Nazarova , -
The Importance Of Immunoprophylaxis For Tuberculosis (BCG Vaccination)
The American Journal of Medical Sciences and Pharmaceutical Research: No. 10 (2021) / Bayramgul Sadikovna Jumamuratova, -
Dental Status In Geriatric Population
The American Journal of Medical Sciences and Pharmaceutical Research: No. 08 (2020) / Samatov Ulugbek Abdumajitovich, -
Ecological Aspects Of Polynosis
The American Journal of Medical Sciences and Pharmaceutical Research: No. 04 (2021) / Umurova Nigora Mavlonovna , Ismatova Mehriniso Nasritdinovna, -
OSTEOMUSCULARES ADHERENCE TO PHYSICAL ACTIVITY AMONG HEALTH PROFESSIONALS AND ITS MUSCULOSKELETAL REPERCUSSIONS
The American Journal of Medical Sciences and Pharmaceutical Research: No. 12 (2023) / Bianca Gabriella de Oliveira , Melissa Alves Aires Marques , Gabriel Oliveira Zacheo , Juliana Farias Araujo , Maria Eduarda Bastos Tinoco , Fabricio Negreiros Holtz , Rafael Costa Nerys, Laís Cristina Pereira da Silva , Marcella Rodrigues costa Simoes , -
Clinical And Morphological Assessment Of The Effectiveness Of Application Of Anti-Inflammatory Toothpasts In The Complex Treatment Of Periodontal Diseases In Patients With Glucose Exchange
The American Journal of Medical Sciences and Pharmaceutical Research: No. 12 (2020) / Xolboyeva Nasiba Asrorovna , Turayeva Kamila Furqat Qizi , -
Dangerous Symptoms Of Covid-19 Virus And Analysis Of Their Characteristics
The American Journal of Medical Sciences and Pharmaceutical Research: No. 10 (2021) / A.B. Tleubergenova , Z.U. Kunnazarova, -
Characteristics Of Articulate Syndrome In Patients With Reactive Arthritis
The American Journal of Medical Sciences and Pharmaceutical Research: No. 01 (2021) / Khalmetova F.I., Akhmedov K.S., -
ETHIO-PATHOGENESIS OF POUND DESTROYMENT IN CHILDREN
The American Journal of Medical Sciences and Pharmaceutical Research: No. 02 (2024) / Kadirov K.Z., Isroilov R.I.,
References
Roma Patel, Nishant Parmar, Sayantani Pramanik Palit, Nirali Rathwa, A.V. Ramachandran, Rasheedunnisa Begum,Diabetes mellitus and melatonin: Where are we?, Biochimie, Volume 202, 2022, Pages 2-14, ISSN 0300-9084, https://doi.org/10.1016/j.biochi.2022.01.001.
Pourhanifeh MH, Hosseinzadeh A, Dehdashtian E, Hemati K, Mehrzadi S. Melatonin: new insights on its therapeutic properties in diabetic complications. Diabetol Metab Syndrome (2020) 12:1–20. doi: 10.1186/s13098-020-00537-z
Lyssenko V, Nagorny CL, Erdos MR, Wierup N, Jonsson A, Spegel P, et al. Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion. Nat Genet. 2009;41(1):82-8.
Alves M, Martins A, Rato L, Moreira P, Socorro S, Oliveira P. Molecular mechanisms beyond glucose transport in diabetes-related male infertility. Biochim Biophys Acta (BBA)-Molecular Basis Dis (2013) 1832(5):626–35. doi: 10.1016/j.bbadis.2013.01.011
Jesus Lopez-Minguez, Richa Saxena, Cristina Bandín, Frank A. Scheer, Marta Garaulet, Late dinner impairs glucose tolerance in MTNR1B risk allele carriers: A randomized, cross-over study, Clinical Nutrition, Volume 37, Issue 4, 2018, Pages 1133-1140, ISSN 0261-5614, https://doi.org/10.1016/j.clnu.2017.04.003.
Rezvanfar MR, Heshmati G, Chehrei A, Haghverdi F, Rafiee F, Rezvanfar F. Effect of bedtime melatonin consumption on diabetes control and lipid profile. Int J Diabetes Developing Countries (2017) 37(1):74–7. doi: 10.1007/s13410-016-0497-2
Joshua H. Cho, Saumya Bhutani, Carole H. Kim, Michael R. Irwin, Anti-inflammatory effects of melatonin: A systematic review and meta-analysis of clinical trials, Brain, Behavior, and Immunity, Volume 93, 2021, Pages 245-253, ISSN 0889-1591, https://doi.org/10.1016/j.bbi.2021.01.034.
Felipe Mendes Delpino, Lílian Munhoz Figueiredo, Bruno Pereira Nunes, Effects of melatonin supplementation on diabetes: A systematic review and meta-analysis of randomized clinical trials, Clinical Nutrition, Volume 40, Issue 7, 2021, Pages 4595-4605, ISSN 0261-5614, https://doi.org/10.1016/j.clnu.2021.06.007.
Allaman-Pillet N, Roduit R, Oberson A, Abdelli S, Ruiz J, Beckmann JS, et al. Circadian regulation of islet genes involved in insulin production and secretion. Molecular and cellular endocrinology. 2004;226(1-2):59-66.
Karamitri A, Renault N, Clement N, Guillaume JL, Jockers R. Minireview: Toward the establishment of a link between melatonin and glucose homeostasis: association of melatonin MT2 receptor variants with type 2 diabetes. Molecular endocrinology (Baltimore, Md). 2013;27(8):1217-33.
Nduhirabandi F., Du Toit E.F., Blackhurst D., Marais D., Lochner A. Chronic melatonin consumption prevents obesity-related metabolic abnormalities and protects the heart against myocardial ischemic and reperfusion injury in a prediabetic model of dietinduced obesity. J Pineal Res 2011; 50: 171—182.
Marta Garaulet, Jingyi Qian, Jose C. Florez, Josephine Arendt, Richa Saxena, Frank A.J.L. Scheer, Melatonin Effects on Glucose Metabolism: Time To Unlock the Controversy, Trends in Endocrinology & Metabolism, Volume 31, Issue 3, 2020, Pages 192-204, ISSN 1043-2760, https://doi.org/10.1016/j.tem.2019.11.011.
Aylamazyan EK, Evsyukova II, Yarmolinskaya ML. The role of melatonin in the development of gestational diabetes. MOJ Curr Res & Rev. 2018;1(4):159-162. DOI:10.15406/mojcrr.2018.01.00025
Farrar D, Simmonds M, Bryant M, et al. Risk factor screening to identify women requiring oral glucose tolerance testing to diagnose gestational diabetes: A systematic review and meta-analysis and analysis of two pregnancy cohorts. PLoS One. 2017;12(8):e0175288.
McMullan CJ, Schernhammer ES, Rimm EB, et al. Melatonin secretion and the incidence of type 2 diabetes. JAMA. 2013;309(13):1388–1396.
Reiter RJ, Tan DX, Korkmaz A, et al. Melatonin and stable circadian rhythms optimize maternal, placental and fetal physiology. Hum Reprod Update. 2014;20(2):293–307.
de Melo IMF, Ferreira CGM, Alves ÉR, D'Assunção CG, Neto CJCL, de Albuquerque YML, Wanderley Teixeira V, Teixeira ÁAC. Melatonin Administration Prevents Placental and Fetal Changes Induced by Gestational Diabetes. Reprod Sci. 2022 Apr;29(4):1111-1123. doi: 10.1007/s43032-022-00850-
Verteramo, R.; Pierdomenico, M.; Greco, P.; Milano, C. The Role of Melatonin in Pregnancy and the Health Benefits for the Newborn. Biomedicines 2022, 10, 3252. https://doi.org/10.3390/ biomedicines10123252
Sagrillo-Fagundes, L.; Assunção Salustiano, E.M.; Ruano, R.; Markus, R.P.; Vaillancourt, C. Melatonin modulates autophagy and inflammation protecting human placental trophoblast from hypoxia/reoxygenation. J. Pineal Res. 2018, 65, e12520.
