EFFICACY OF LYMPHOTROPIC ADMINISTRATION OF BACTOX (AMOXICILIN) IN THE TREATMENT OF CHRONIC PNEUMONIA IN CHILDREN

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Abstract

Lung inflammation, also called pneumonia, is a pathological process that affects lung tissue. It occurs in both adults and children. Inflammation of the lungs needs urgent treatment, even if it is not severe. Pneumonia is mainly caused by an infection - an invasion of the lung by pathogenic organisms. Therefore, the use of antibiotics for pneumonia in adults and children, together with complementary medicines, is the mainstay of treatment.

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4

Volume 04 Issue 02-2022


The American Journal of Medical Sciences and Pharmaceutical Research
(ISSN

2689-1026)

VOLUME

04

I

SSUE

02

Pages:

4-6

SJIF

I

MPACT

FACTOR

(2020:

5.

286

)

(2021:

5.

64

)

OCLC

1121105510

METADATA

IF

7.569















































Publisher:

The USA Journals

ABSTRACT

Lung inflammation, also called pneumonia, is a pathological process that affects lung tissue. It occurs in both adults
and children. Inflammation of the lungs needs urgent treatment, even if it is not severe. Pneumonia is mainly caused
by an infection - an invasion of the lung by pathogenic organisms. Therefore, the use of antibiotics for pneumonia in
adults and children, together with complementary medicines, is the mainstay of treatment.

KEYWORDS

Pneumonia, children , antibiotics, Bactox (Amoxicillin).

Research Article


EFFICACY OF LYMPHOTROPIC ADMINISTRATION OF BACTOX
(AMOXICILIN) IN THE TREATMENT OF CHRONIC PNEUMONIA IN
CHILDREN

Submission Date:

February 10, 2022,

Accepted Date:

February 20, 2022,

Published Date:

February 28, 2022 |

Crossref doi:

https://doi.org/10.37547/TAJMSPR/Volume04Issue02-02


A.M. Vakhidova

Department of Microbiology, Virology and Immunology Samarkand State Medical University Samarkand,
Uzbekistan

G. N. Khudoyarova

Department of Microbiology, Virology and Immunology Samarkand State Medical University Samarkand,
Uzbekistan


Z.T.Muratova

Department of Microbiology, Virology and Immunology Samarkand State Medical University Samarkand,
Uzbekistan

Journal

Website:

https://theamericanjou
rnals.com/index.php/ta
jmspr

Copyright:

Original

content from this work
may be used under the
terms of the creative
commons

attributes

4.0 licence.


background image

5

Volume 04 Issue 02-2022


The American Journal of Medical Sciences and Pharmaceutical Research
(ISSN

2689-1026)

VOLUME

04

I

SSUE

02

Pages:

4-6

SJIF

I

MPACT

FACTOR

(2020:

5.

286

)

(2021:

5.

64

)

OCLC

1121105510

METADATA

IF

7.569















































Publisher:

The USA Journals

INTRODUCTION

One of the promising methods in modern medicine is
regional lymphatic antibiotic therapy (RLAT) and
regional lymphostimulation (RLS). In our studies, we
used bactox (amoxicillin), a protected penicillin
antibiotic, in the traditional and main groups of
patients. Bactox was administered intramuscularly to
the patients of the traditional group, and to the main
group - regionally by lymphotropic route.

PURPOSE OF THE PRESENT STUDY

To determine clinical and immunological efficacy of
Bactox (Amoxicillin) in chronic pneumonia in children.

MATERIALS AND METHODS OF STUDY

Bactox was used in 67 children with chronic
pneumonia,

antibiotic

was

administered

at

exacerbation of bronchopulmonary process after
identification of pathogenic microflora isolated from
sputum. Microbial sensitivity was tested by the disc-
diffusion method to determine the most effective
drug. All examined children with chronic pneumonia
were divided into 2 groups: Group 1 consisted of 37
patients who received Bactox with intramuscular
administration in a dose of 50 mg/kg 2 times a day,
Group 2 consisted of 30 children who received
antibiotic by pretracheal lymphatic route in a dose of
25 mg/kg once a day. RLATs were given once, in severe
cases twice a day. The daily dose of Bactox was ½ of
the dose administered by the conventional route of
administration. The total number of manipulations
ranged from 8 to 12 injections. Heparin 50 U/kg of child
weight was used as lymphostimulator.

RESULTS AND DISCUSSION

The effectiveness of therapy was evaluated by the
dynamics of clinical and paraclinical data.

It was found that the main symptoms of the disease in
the group of children treated with RLAT were relieved
within a shorter time compared to patients treated
with traditional methods.

Signs of intoxication disappeared on 12.8±0.8 days,
compared to 18.3±1.3 (p<0.01), cough duration and
sputum discharge diminished on 9.6±0.9 days versus
15.2±0.3 (p<0.05), dyspnea and cyanosis on 7.1±0.1 day
versus 9.2±0.6 days (p<0.01), 6 days (p<0.01),
percussive changes in lungs on 8.7±0.4 day vs 13.8±0.5
(p<0.01), auscultatory findings (rales and respiratory
changes) on 11.1±0.3 day vs 15.2±0.2 (p<0.01), duration
of hospitalization on 12.3±0.2 day vs 18.9±0.9 (p<0.01).

Immunological studies in children with chronic
pneumonia showed a marked decrease in cellular
immunity and phagocytic activity of neutrophils,
indicating

secondary

immunodeficiency.

The

emergence of exacerbation of the disease contributes
to the perversion of local immune reactions, up to the
development

of

secondary

immunodeficiency.

Application of lymphotropic antibiotic administration
of Bactox in children with chronic pneumonia
contributed to a more rapid recovery of both absolute
and relative numbers of T-lymphocytes and their
subpopulation. In children group receiving RLLAT,
immunoglobulin content reliably decreased, while in
the control group it was 1.2 times higher than in healthy
children, indicating the continuing activity of the
inflammatory process in the lungs. It was also
interesting to evaluate the results of lung tissue
antigen binding lymphocyte (ALA) tests against a
background of different treatments: ALA levels
remained high (p>0,05) in patients treated with
conventional therapy, while ALA levels significantly
and significantly decreased (p<0,01) in children who
received RLLT at discharge, indicating a more complete


background image

6

Volume 04 Issue 02-2022


The American Journal of Medical Sciences and Pharmaceutical Research
(ISSN

2689-1026)

VOLUME

04

I

SSUE

02

Pages:

4-6

SJIF

I

MPACT

FACTOR

(2020:

5.

286

)

(2021:

5.

64

)

OCLC

1121105510

METADATA

IF

7.569















































Publisher:

The USA Journals

removal of the inflammatory process in the lungs when
using RLLT.

Under the influence of lymphotropic administration of
Bactox the concentration of circulating immune
complexes sharply decreased up to 132,2±8,4%, and the
concentration of CIC significantly changed in
comparison with the data before the treatment and
was 154,1±9,4%. It should be noted that on the
background of conventional therapy, immunological
parameters improved only in 68.7% of patients, while
the application of RLLT in 88.9% of patients.

Overall, the effect of clinical and immunological
correction was better with the proposed method of
treatment than with conventional treatment. The
antibacterial effect of RLAT with Bactox was
accompanied by an immunostimulatory effect, the
mechanism

of

which

was

related

to

the

lymphostimulatory

effect

of

heparin.

Lymphostimulation in chronic pneumonia in children
promotes the outflow from tissues of toxic
substances, their neutralisation in lymph nodes,
restoring the immune protection.

CONCLUSIONS

Thus, our clinical and immunological investigations
testify to considerable effectiveness of RLLAT in
complex treatment of chronic pneumonia in children.

REFERENCES

1.

Akhmatov H., Aminov A., Vahidova A.M. The search
for the most effective drugs in echinococcosis and
pecilomycosis //Student research. 2019. С. 155-158.

2.

Vahidova A. M. et al. Fungi of the genus pacilomyces
in human echinococcosis //World Science: Problems
and Innovations. 2019. С. 186-190.

3.

Avdeev S.N. Chronic obstructive pulmonary disease
in tables and diagrams. // Atmosphera Publishing
House. Moscow, 2003. 23 с.

4.

MI Kamalova, S Khaminov, B Eshboltaeva
Morphometric features of bronchial epithelium
development

in

rabbits

in

postnatal

ontogenesisAzimov M. I., Shomurodov K.E. A
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5.

Khaidarov

Nodir

Kadyrovich,

Shomurodov

Kahramon

Erkinovich,

&

Kamalova

Malika

Ilhomovna. (2021). Microscopic Examination Of
Postcapillary Cerebral Venues In Hemorrhagic
Stroke. The American Journal of Medical Sciences
and Pharmaceutical Research, 3(08), 69–73

6.

Shomurodov , K., Khaidarov , N., & Kamalova , M.
(2021). The formation and eruption of baby teeth in
children. Збірник наукових праць scientia.
Вилучено із

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Ismoilov, O. I., Murodkosimov, S. M., Kamalova, M.
I., Turaev, A. Y., & Mahmudova, S. K. (2021). The
Spread Of SARS-Cov-2 Coronavirus In Uzbekistan
And Current Response Measures. The American
Journal of Medical Sciences and Pharmaceutical
Research, 3(03), 45-50.

8.

Aralov, N. R., Makhmatmuradova, N. N., Zakiryaeva,
P. O., & Kamalova, M. I. Distinctive Features Of Non-
Specific Interstitial Pneumonia. 2020.

9.

Yarmukhamedova S. Kh., Vakhidova a.m., Ismoilova
M. sh., Amirova sh. a. Structural and functional
heart disorders at different stages of chronic heart
failure

in

patients

with

postinfarction

cardiosclerosis and dilated cardiomyopathy //
Modern technologies: problems of innovative
development, Kemerovo, 2019, p. 268-272.

References

Akhmatov H., Aminov A., Vahidova A.M. The search for the most effective drugs in echinococcosis and pecilomycosis //Student research. 2019. С. 155-158.

Vahidova A. M. et al. Fungi of the genus pacilomyces in human echinococcosis //World Science: Problems and Innovations. 2019. С. 186-190.

Avdeev S.N. Chronic obstructive pulmonary disease in tables and diagrams. // Atmosphera Publishing House. Moscow, 2003. 23 с.

MI Kamalova, S Khaminov, B Eshboltaeva Morphometric features of bronchial epithelium development in rabbits in postnatal ontogenesisAzimov M. I., Shomurodov K.E. A technique for Cleft Palate Repair. Journal of research in health science. Vol. 1, No. 2, 2018, pp. 56- 59.

Khaidarov Nodir Kadyrovich, Shomurodov Kahramon Erkinovich, & Kamalova Malika Ilhomovna. (2021). Microscopic Examination Of Postcapillary Cerebral Venues In Hemorrhagic Stroke. The American Journal of Medical Sciences and Pharmaceutical Research, 3(08), 69–73

Shomurodov , K., Khaidarov , N., & Kamalova , M. (2021). The formation and eruption of baby teeth in children. Збірник наукових праць scientia. Вилучено із

Ismoilov, O. I., Murodkosimov, S. M., Kamalova, M. I., Turaev, A. Y., & Mahmudova, S. K. (2021). The Spread Of SARS-Cov-2 Coronavirus In Uzbekistan And Current Response Measures. The American Journal of Medical Sciences and Pharmaceutical Research, 3(03), 45-50.

Aralov, N. R., Makhmatmuradova, N. N., Zakiryaeva, P. O., & Kamalova, M. I. Distinctive Features Of NonSpecific Interstitial Pneumonia. 2020.

Yarmukhamedova S. Kh., Vakhidova a.m., Ismoilova M. sh., Amirova sh. a. Structural and functional heart disorders at different stages of chronic heart failure in patients with postinfarction cardiosclerosis and dilated cardiomyopathy // Modern technologies: problems of innovative development, Kemerovo, 2019, p. 268-272.

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