4
Volume 04 Issue 02-2022
The American Journal of Medical Sciences and Pharmaceutical Research
(ISSN
–
2689-1026)
VOLUME
04
I
SSUE
02
Pages:
4-6
SJIF
I
MPACT
FACTOR
(2020:
5.
286
)
(2021:
5.
64
)
OCLC
–
1121105510
METADATA
IF
–
7.569
Publisher:
The USA Journals
ABSTRACT
Lung inflammation, also called pneumonia, is a pathological process that affects lung tissue. It occurs in both adults
and children. Inflammation of the lungs needs urgent treatment, even if it is not severe. Pneumonia is mainly caused
by an infection - an invasion of the lung by pathogenic organisms. Therefore, the use of antibiotics for pneumonia in
adults and children, together with complementary medicines, is the mainstay of treatment.
KEYWORDS
Pneumonia, children , antibiotics, Bactox (Amoxicillin).
Research Article
EFFICACY OF LYMPHOTROPIC ADMINISTRATION OF BACTOX
(AMOXICILIN) IN THE TREATMENT OF CHRONIC PNEUMONIA IN
CHILDREN
Submission Date:
February 10, 2022,
Accepted Date:
February 20, 2022,
Published Date:
February 28, 2022 |
Crossref doi:
https://doi.org/10.37547/TAJMSPR/Volume04Issue02-02
A.M. Vakhidova
Department of Microbiology, Virology and Immunology Samarkand State Medical University Samarkand,
Uzbekistan
G. N. Khudoyarova
Department of Microbiology, Virology and Immunology Samarkand State Medical University Samarkand,
Uzbekistan
Z.T.Muratova
Department of Microbiology, Virology and Immunology Samarkand State Medical University Samarkand,
Uzbekistan
Journal
Website:
https://theamericanjou
rnals.com/index.php/ta
jmspr
Copyright:
Original
content from this work
may be used under the
terms of the creative
commons
attributes
4.0 licence.
5
Volume 04 Issue 02-2022
The American Journal of Medical Sciences and Pharmaceutical Research
(ISSN
–
2689-1026)
VOLUME
04
I
SSUE
02
Pages:
4-6
SJIF
I
MPACT
FACTOR
(2020:
5.
286
)
(2021:
5.
64
)
OCLC
–
1121105510
METADATA
IF
–
7.569
Publisher:
The USA Journals
INTRODUCTION
One of the promising methods in modern medicine is
regional lymphatic antibiotic therapy (RLAT) and
regional lymphostimulation (RLS). In our studies, we
used bactox (amoxicillin), a protected penicillin
antibiotic, in the traditional and main groups of
patients. Bactox was administered intramuscularly to
the patients of the traditional group, and to the main
group - regionally by lymphotropic route.
PURPOSE OF THE PRESENT STUDY
To determine clinical and immunological efficacy of
Bactox (Amoxicillin) in chronic pneumonia in children.
MATERIALS AND METHODS OF STUDY
Bactox was used in 67 children with chronic
pneumonia,
antibiotic
was
administered
at
exacerbation of bronchopulmonary process after
identification of pathogenic microflora isolated from
sputum. Microbial sensitivity was tested by the disc-
diffusion method to determine the most effective
drug. All examined children with chronic pneumonia
were divided into 2 groups: Group 1 consisted of 37
patients who received Bactox with intramuscular
administration in a dose of 50 mg/kg 2 times a day,
Group 2 consisted of 30 children who received
antibiotic by pretracheal lymphatic route in a dose of
25 mg/kg once a day. RLATs were given once, in severe
cases twice a day. The daily dose of Bactox was ½ of
the dose administered by the conventional route of
administration. The total number of manipulations
ranged from 8 to 12 injections. Heparin 50 U/kg of child
weight was used as lymphostimulator.
RESULTS AND DISCUSSION
The effectiveness of therapy was evaluated by the
dynamics of clinical and paraclinical data.
It was found that the main symptoms of the disease in
the group of children treated with RLAT were relieved
within a shorter time compared to patients treated
with traditional methods.
Signs of intoxication disappeared on 12.8±0.8 days,
compared to 18.3±1.3 (p<0.01), cough duration and
sputum discharge diminished on 9.6±0.9 days versus
15.2±0.3 (p<0.05), dyspnea and cyanosis on 7.1±0.1 day
versus 9.2±0.6 days (p<0.01), 6 days (p<0.01),
percussive changes in lungs on 8.7±0.4 day vs 13.8±0.5
(p<0.01), auscultatory findings (rales and respiratory
changes) on 11.1±0.3 day vs 15.2±0.2 (p<0.01), duration
of hospitalization on 12.3±0.2 day vs 18.9±0.9 (p<0.01).
Immunological studies in children with chronic
pneumonia showed a marked decrease in cellular
immunity and phagocytic activity of neutrophils,
indicating
secondary
immunodeficiency.
The
emergence of exacerbation of the disease contributes
to the perversion of local immune reactions, up to the
development
of
secondary
immunodeficiency.
Application of lymphotropic antibiotic administration
of Bactox in children with chronic pneumonia
contributed to a more rapid recovery of both absolute
and relative numbers of T-lymphocytes and their
subpopulation. In children group receiving RLLAT,
immunoglobulin content reliably decreased, while in
the control group it was 1.2 times higher than in healthy
children, indicating the continuing activity of the
inflammatory process in the lungs. It was also
interesting to evaluate the results of lung tissue
antigen binding lymphocyte (ALA) tests against a
background of different treatments: ALA levels
remained high (p>0,05) in patients treated with
conventional therapy, while ALA levels significantly
and significantly decreased (p<0,01) in children who
received RLLT at discharge, indicating a more complete
6
Volume 04 Issue 02-2022
The American Journal of Medical Sciences and Pharmaceutical Research
(ISSN
–
2689-1026)
VOLUME
04
I
SSUE
02
Pages:
4-6
SJIF
I
MPACT
FACTOR
(2020:
5.
286
)
(2021:
5.
64
)
OCLC
–
1121105510
METADATA
IF
–
7.569
Publisher:
The USA Journals
removal of the inflammatory process in the lungs when
using RLLT.
Under the influence of lymphotropic administration of
Bactox the concentration of circulating immune
complexes sharply decreased up to 132,2±8,4%, and the
concentration of CIC significantly changed in
comparison with the data before the treatment and
was 154,1±9,4%. It should be noted that on the
background of conventional therapy, immunological
parameters improved only in 68.7% of patients, while
the application of RLLT in 88.9% of patients.
Overall, the effect of clinical and immunological
correction was better with the proposed method of
treatment than with conventional treatment. The
antibacterial effect of RLAT with Bactox was
accompanied by an immunostimulatory effect, the
mechanism
of
which
was
related
to
the
lymphostimulatory
effect
of
heparin.
Lymphostimulation in chronic pneumonia in children
promotes the outflow from tissues of toxic
substances, their neutralisation in lymph nodes,
restoring the immune protection.
CONCLUSIONS
Thus, our clinical and immunological investigations
testify to considerable effectiveness of RLLAT in
complex treatment of chronic pneumonia in children.
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