8
Volume 04 Issue 04-2022
The American Journal of Medical Sciences and Pharmaceutical Research
(ISSN
–
2689-1026)
VOLUME
04
I
SSUE
04
Pages:
8-10
SJIF
I
MPACT
FACTOR
(2020:
5.
286
)
(2021:
5.
64
)
(2022:
6.
319
)
OCLC
–
1121105510
METADATA
IF
–
7.569
Publisher:
The USA Journals
ABSTRACT
In recent years, the world has seen a significant increase in the incidence of sexually transmitted infections, including
syphilis. Despite the progress made in venereology, the problem of syphilis is an urgent problem of our time, and this
especially concerns serological resistance in syphilis. Among practitioners and scientists involved in the treatment of
syphilis, it is widely believed that there is an increase in the number of cases of seroresistance among patients treated
for syphilis.
KEYWORDS
Biochemical indicators, syphilis, serological indicators.
INTRODUCTION
Based on a comprehensive study of clinical-serological,
immunological, biochemical studies, to determine the
probable risks of serological resistance in syphilis.
Based on probabilistic criteria, optimize the methods
of specific treatment of seroresistance. The following
tasks were set for the correction of syphilis. To
determine the state of the immune status in patients
with seroresistant syphilis before and after specific
Research Article
BIOCHEMICAL, IMMUNOLOGICAL, SEROLOGICAL INDICATORS FOR
SERORESISTANT SYPHILIS, CORRECTION IN TREATMENT
Submission Date:
April 05, 2022,
Accepted Date:
April 15, 2022,
Published Date:
April 28, 2022 |
Crossref doi:
https://doi.org/10.37547/TAJMSPR/Volume04Issue04-02
K. A. Yuldashev
Professor, Supervisor: Doctor of Medical Sciences, Uzbekistan
Abzoirov Kudrat Musulmanovich
Republican Scientific And Practical Medical Center For Dermatology And Venerology Ministry Of Health Of
The Republic Of Uzbekistan
Journal
Website:
https://theamericanjou
rnals.com/index.php/ta
jmspr
Copyright:
Original
content from this work
may be used under the
terms of the creative
commons
attributes
4.0 licence.
9
Volume 04 Issue 04-2022
The American Journal of Medical Sciences and Pharmaceutical Research
(ISSN
–
2689-1026)
VOLUME
04
I
SSUE
04
Pages:
8-10
SJIF
I
MPACT
FACTOR
(2020:
5.
286
)
(2021:
5.
64
)
(2022:
6.
319
)
OCLC
–
1121105510
METADATA
IF
–
7.569
Publisher:
The USA Journals
treatment. To study the state of internal organs and
the nervous system in patients with seroresistant
syphilis using ultrasound, REG, EEG and other
diagnostic methods. To study the state of serological
and biochemical parameters of cerebrospinal fluid
before and after specific treatment. To optimize the
tactics and methods of treatment of seroresistant
syphilis. The problem of sexually transmitted diseases,
including syphilis, is very relevant at the present time.
According to the World Health Organization,
spirochete pallidum, the causative agent of syphilis,
infects 50 million people every year. The incidence of
syphilis, despite all the measures taken, continues to
be high, which is associated with the safety of the
reservoirs of its spread. Syphilitic infection in terms of
incidence, medical and social significance, threat to the
health of the nation, certain difficulties in diagnosis and
treatment, occupies a special place not only among
sexually transmitted infections (STIs), but also in all
infectious pathology. Syphilitic infection is inexorable
not only in relation to sex, but also to age. The
epidemiological situation of syphilis in the countries of
the post-Soviet space, associated with deep economic
and social transformations, once again highlighted the
shortcomings
in
the
clinical
and
laboratory
examination and treatment of patients with syphilis.
One of the most urgent and most difficult problems,
both in practical and theoretical syphilidology, was the
problem of seroresistance after syphilis treatment. It
should be noted that a detailed discussion on the
pages of the journal "Bulletin of Dermatology and
Venereology" in the 80s of the last century between
leading syphilidologists revealed more questions than
answers. Moreover, disagreements among various
authors concern the very definition of this state. So, if
some authors propose the term "ser-resistant
syphilis", others consider its use somewhat inaccurate,
and propose to qualify this condition as "ser-resistant
after a full treatment of syphilis". In recent years, in
medical practice, the opinion of an increase in the
number of cases of seroresistance has been widely
spread. This phenomenon is explained, first of all, by
the unprecedentedly high incidence during the
epidemic of the 90s, many believe that this is due to
the methods of treatment used during this period: the
widespread use of foreign penicillin durant drugs and
the shortening of the duration of treatment. However,
some authors believe that the very concept of
"seroresistance" is ambiguous. The study of
seroresistance has deep roots; in the last century,
many scientific works were devoted to this problem,
starting with the works of M.N. Bukharovich (1964),
L.M. Dubashevskaya-Zenina and ending with the works
of S.I. Danilova (1986) and E.V. Sokolovsky (1985). The
group of serological studies included a complex of
classical (microprecipitation reaction, Wasserman
reaction with cardiolipin and ultrasound treponemal
antigens) and specific (immunofluorescence reaction
in two modifications and the immobilization reaction
of pale treponema) reactions. Microprecipitation
reaction. The principle of the method is based on the
precipitation in the form of white flakes of an antigen-
antidiv complex, a precipitate formed by adding an
emulsion of a cardiolipin antigen to the blood serum of
a patient with syphilis. Wasserman reaction (RV). The
essence of the method lies in the phenomenon of
complement binding. In the formulation of the
reaction, specific (antigens from pale treponema) and
nonspecific antigens (extract of the muscle of a bovine
heart) are used. Complement fixation is produced by a
complex of lipoid antigen and reagin of the test
serum). To indicate the complex, a hemolytic system is
used (sheep erythrocytes and hemolytic serum).
Statement of RV with cardilipin antigen is more
sensitive. Immunofluorescence reaction. The principle
of the method is based on the detection of fluorescent
antibodies, since fluorochrome-labeled antibodies do
not lose their ability to bind to the corresponding
10
Volume 04 Issue 04-2022
The American Journal of Medical Sciences and Pharmaceutical Research
(ISSN
–
2689-1026)
VOLUME
04
I
SSUE
04
Pages:
8-10
SJIF
I
MPACT
FACTOR
(2020:
5.
286
)
(2021:
5.
64
)
(2022:
6.
319
)
OCLC
–
1121105510
METADATA
IF
–
7.569
Publisher:
The USA Journals
antigen and thereby cause the drugs to glow in blue-
violet rays, the source of which is a mercury-quartz
lamp. Instrumental research methods. The technique
of lumbar puncture and the study of cerebrospinal fluid
by biochemical and serological methods. Spinal
puncture was performed in the department in a room
specially designated for this purpose. The patient was
in a sitting position, with his head lowered to his chest,
while his back had to be arched, his hands folded on his
stomach. The puncture site was determined along the
line connecting the superior iliac crests, which
corresponded to the intervertebral fissure of the III
and IV lumbar vertebrae. The development of
seroresistance in syphilis is due to many factors, among
which not the last role belongs to the phenomena of
endotoxicosis of the div. In this regard, we studied
the state of the syndrome of endogenous intoxication
of the div by determining the level of medium
molecular weight peptides and the sorption capacity of
the liver. The leukocyte and hematological (GPI) index
of intoxication were also calculated. The study of
indicators of endogenous intoxication in patients with
syphilis was carried out by some domestic researchers,
however, in patients with seroresistant syphilis, we
carried out for the first time. Seroresistance after a full-
fledged specific treatment occurs against the
background of disturbed indicators of the T-cell link of
cellular immunity and an increased syndrome of
endogenous intoxication. The study of the state of
internal organs and the nervous system in patients
with seroresistance reveals multiple organ disorders,
among which the largest proportion is occupied by
neurological disorders. The study of the nervous
system of patients with seroresistance using an
electroencephalogram and a rheoencephalogram
reveals functional changes in the bioelectrical activity
of the brain in 29% of the examined, changes in cerebral
hemodynamics in 73.1% of the examined, and more
pronounced changes correlate with the duration of the
disease. Additional treatment with three treatment
modalities showed the advantages of ceftriaxone,
especially when administered by the lymphotropic
method, as a result of treatment with which it is
possible to achieve a shift towards negative serological
reactions in more than half of the patients.
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