Effects Of F-18 On KCL And Phenylephrine - Induced Contractions Of Rat Aorta

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Zaripov, A. ., Esimbetov, A. ., Usmanov, P. ., Shokirova, D. ., & Zhurakulov, S. . (2021). Effects Of F-18 On KCL And Phenylephrine - Induced Contractions Of Rat Aorta. The American Journal of Medical Sciences and Pharmaceutical Research, 3(06), 100–108. https://doi.org/10.37547/TAJMSPR/Volume03Issue06-16
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Abstract

The mechanism of action of the alkaloid 1-(2´-bromine-4´,5´-dimethoxyphenyl) - 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline (F-18) on the functional activity of smooth muscle cells of the rat aorta was studied. Isometric contraction activity was recorded using a Grass FT – 03 (Grass Instrument, USA) mechanotron. The relaxant effect of the F-18 alkaloid was found to be associated with blockade of Ca2 + (IP3R) channels in the SR, along with voltage- dependent and receptor-operated Ca2+channels in the aorta smooth muscle cell plasmalemma.

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