All articles - Life Sciences Biomedicine Other Topics
Number of articles: 499
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Predictive study of penetrating ability 5% glucose solution into insulin- dependent organ cells mice exposed to ionizing radiation.The article reflects the results of an experimental study of the effect of ionizing radiation on the organs of animals of 30 intact opposite-sex BALB / c mice, 15 individuals of each sex. The age of the animals ranged from 2 to 3 months. Body weight from 18 to 22 grams.
Medicine and innovations -
MORPHOLOGICAL CHANGES IN THE SKIN OF RATS SUBJECTED TO PROPHYLACTIC REDERMALIZATIONThe article describes the results of experimental work on rats, in order to study the reparative changes in the skin wound during injections of the succinatc-containing preparation HYALUAL. The objective of the research was a comparative description of the structural changes in the skin in control and experimental rats with publicly available morphological research methods.
Medicine and innovations -
Based on the conducted research, the safety of the use of the new insecticide Seller in agriculture was established. Scientifically substantiated the maximum permissible concentration of insecticide in atmospheric air, air of the working area, in the soil. Approximately permissible concentration of the drug in products of plant origin, in the water of water bodies has been developed. -
Macroscopic and microscopic characteristics of kidneys of white unbored rats after severe cranial injuryThis article provides information on the results of scientific studies that allow to evaluate and study the features of macroscopic and microscopic characteristics of the kidneys of 3-month-old white outbred rats with severe traumatic brain injury. Traumatic brain injury was performed using the Traffic Accident model, and rat kidneys were isolated and macroscopic and microscopic examinations were performed in the order in which anatomical parameters were established.
Doctor's Herald -
The article discuss issues of creatine use safety in pregnant women. Literature search has shown that although the use of creatine during pregnancy in humans is not yet fully understood, long-term use of this agent in adults is considered absolutely safe. Authors discourse about creatine synthesis pathways by the fetus, the mechanisms of transfer through the placental barrier. Considerable attention is paid on evidence of benefit of creatine supplementation during pregnancy for prevention and reduction of oxidative stress, fetoplacental hypoxia arising from various types gestational complications, such as fetal growth restriction, premature birth, and cases of fetal hypoxic conditions. -
The purpose of the study is to assess the environmental and hygienic impact of production factors on the health of poultry farm workers and to develop measures to improve working conditions, improve the environmental situation on the territory of farms. It is established that the unfavorable factors of the production environment of poultry farms are strenuous physical labor, neuropsychiatric stress, the impact on the human body of chemicals, bacterial and dust aerosols, fungal microflora, excrement and other products of poultry life. -
THE IMPORTANCE OF REDUCING THE LEVEL OF PROTEIN–POLYSACCHARIDE COMPLEXES IN THE PROCESS OF GASTRICDIGESTIONThe effect of gastric hydrolysis of proteins on the formation of protein-polysaccharide complexes was studied. The study was conducted in vitro, gastric juice, starch, casein, albumin solutions, as well as casein and albumin hydrolysates were used in the work. It is concluded that the use of a mixture of starch and casein or albumin contributes to a significant decrease in light transmission, which is the inverse of the increase in turbidity of the solution. Simultaneously, an increase in turbidity may be a consequence of the formation of starch-casein or starch-albumin complexes. Simultaneously, the use of a mixture of starch and casein hydrolysate or albumin hydrolysate contributes to higher light transmission or lower turbidity of the solution, which may be a consequence of the low formation of starch complexes and protein hydrolysates. The obtained results also demonstrate that the hydrolysis of proteins by pepsin of the stomach contributes to a decrease in the number of protein-polysaccharide complexes.
Doctor's Herald -
MORPHOLOGICAL CHANGES IN THE SPLEEN TISSUE OF LABORATORY RATS ON THE THIRD DAY AFTER A TRAUMATIC BRAIN INJURYLaboratory studies were conducted on 26 white mongrel rats of 3 months of age. This study was conducted three days after receiving a traumatic brain injury. The animals were fixed on a device made by hand in the form of a vehicle on wheels, the fixed animals were accelerated on the vehicle and hit the wooden barrier with the frontal part of the head. The speed of the vehicle was 6.7 km per hour. As a result of this experiment, two rats died on the spot. In 3-month-old rats, during the experiment, it was revealed that there were no macroscopic changes outside the organ, but there were some changes in the tissue structures of the white and red pulp of the spleen.
Doctor's Herald -
The present pandemic and Severe Acute Respiratory Syndrome (SARS-CoV-2) have resulted in a significant number of deaths worldwide. Today the number of deaths exceeds 4.55 million people. To identify drugs for additional effective treatment of SARS-CoV-2 infection, a screen was created to measure the dimerization of angiotensin converting enzyme 2 (ACE2), the main virus entry receptor into the cell. This screen identified fenofibric acid, the active metabolite of fenofibrate. Fenofibric acid also destabilized the receptor-binding domain (RBD) of the viral spike protein and inhibited the binding of RBD to ACE2 in an enzyme-linked immunosorbent assay (ELISA). Fenofibrate and fenofibric acid have been tested by two independent laboratories. In both cases, at concentrations of the drug in clinical doses, fenofibrate and fenofibric acid reduced viral infection by up to 70% (15. 23]. Together with an extensive history of clinical use and a relatively good safety profile, this study identifies fenofibrate as a potential therapeutic agent requiring clinical evaluation for the treatment of SARS-CoV-2 infection in comorbid patients with hypertension and high body mass index. -
THE MEDICAL SOCIAL CHARACTERISTIC OF THE DOCTOR, THE PRESERVATION AND REHABILITATION OF THEIR HEALTHToday. Uzbekistan government pays attention to problems that related to health condition of rezidents, it requires combination of theoretical and practical medicine. Furthermore, the health situation should be at the good condition. It is important that aim of medicine in Uzbekistan is to maintain healthy adults and medical staffs.
Doctor's Herald -
The effect of vitamin E on rat liver cytochrome P-450 in experimental acute pancreatitis (ЛР) was studied. The animals were divided into 4 groups. The obtained data were compared with the indicators of the 1 -st group (intact). During the experiment, the development of AP showed a decrease in the content of cytochrome P450 in the microsomal fraction. The administration of vitamin E to animals of the 4th group led to an increase in the content of cytochrome P-450, strengthening the protection of the liver, the abolition of inhibition of the monooxygenase system of the liver. -
Acute myeloid leukemia (AML) is the most common acute leukemia in adults. The pathophysiology of this disease is only beginning to be understood at the cellular and molecular level, and cytogenetic markers are currently the most important for risk stratification and treatment of AML patients. However, with the advent of new technologies, the discovery of other molecular markers, such as point mutations, indicates that the disease is approaching. Recent data show that the identification of new biomarkers for AML contributes to a better understanding of the molecular basis of the disease, is significantly useful in screening, diagnosis, prognosis and monitoring of AML. as well as the ability to predict the response of each person to treatment. This review summarizes the most important molecular (genetic, epigenetic, and proteinaceous) biomarkers associated with acute myeloid leukemia and discusses their clinical relevance in terms of risk prediction, diagnosis, and prognosis. -
Cellular composition and mitotic activity lymphocytes in peyer's lymph nodes small intestinal plaques in intact ratsPeyer's patches are an effective tool for protection against the penetration of the pathogen through the gastrointestinal tract. The small intestine, constantly interacting with natural antigens, primarily with microor- ganisms with pronounced immunogenicity, undergoes significant structural and functional rearrangements. They are expressed in changes in the linear parameters of the villi and crypts, accelerating the renewal of en- terocytes, increasing infiltration with inter-epithelial lymphocytes, enriching one's own plate with immunocom- petent cells, clearly forming the structural and functional areas of the PB
Journal problems of biology and medicine -
We examined 52 patients under the age of one year who Were hospitalized in the children’s Department 1 of SamMI in Samarkand in 2018 - 2019; 19 of them were under the age of 6 months; 29 boys and 23 girls. Staphylococci were isolated in 43 children, the control group consisted of 9 patients in whom staphylococci were not detected. A total of 215 strains of staphylococci were isolated from children's feces. And sensitivity to antibiotics (penicillin, streptomycin, gentamicin, levomycetin, tetracycline, cephalosporins, and erythromycin) was studied. Staphylococci are quite often and in large quantities sown from the feces of children with dyspeptic disorders. Staphylococci are characterized by the presence of pathogenicity enzymes and toxigenic properties. Dedicated staphylococci were sensitive to gentamycin and Cefotaxime. -
Currently, in the treatment of urolithiasis (UL) preference is given to herbal preparations. Despite the wide range of herbal medicines (HM) for the treatment of UL, none of those currently used are ideal for the treatment of patients with calcium urolithiasis and preurolithiasis. In this regard, the further research on the study of the properties of drugs from medicinal plants of the Hora of Uzbekistan is important. The goal is to examine the relationship between the anti-lithogenic efficacy and the diuretic power of plant diuretics. Material and methods. In 212 patients with the calcium type of urolithiasis, the diuretic and saluretic abilities of the infusions from seven medicinal plants of the flora of Uzbekistan were investigated. The selected HM are widely known among doctors and patients. Results. Their diuretic ability of HM is different. The strong diuretics: Alhagi pseudoalhagi (+ 65.2%) and Herba Aervea Lanata a (+ 50.19%). The moderate diuretics: Stigmata Maydis (+ 42.12%), Achillea fllipendulina (41.34%) and Hypericum perforatum (+ 29.06%). The weak diuretics: Folia Menthae piperitae (+ 23.53%) and Friictus Rosae (+ 12.59%). The calculation of the ion activity index revealed differences in the severity of the anti-litogenic effect. Infusions were distributed in the following sequence: Alhagi pseudoalhagi (-71.65%) - Achillea fllipendulina (-63.14%) -Herba Aervea Lanata (-49.86%) - Folia Menthae piperitae (-41.36%) - Stigmata Maydis (-33.08%) - Hypericum perforatum (-33.02%) - Fructus Rosae (-15.43%). Conclusion. The strength of the diuretic effect should not be considered the primary factor in the change in the activity of stone formation. Therefore, when prescribing HM, this factor (diuretic effect) is not the main criterion for prevention and metaphy lax is. -
Indices of dysbiosis and inflammation in rats with periodontitis on the background of hyper- and hypothyroidismThe issues of hormonal regulation of inflammatory reactions in periodontium and their development on the background of thyroid gland dysfunction remain insufficiently studied. The markers of inflammation and periodontal microbiocenosis in rats with periodontitis without concomitant pathology and on the background of hyper- and hypothyroidism have been studied. The results of our studies showed that the urease activity in the periodontal tissues homogenate of rats with periodontitis increased by 3.1 times, in rats with periodontitis and hyperthyroidism by 5.1 times, in rats with periodontitis and hypothyroidism by 3.8 times compared to the control group. At the same time, the changes in lysozyme activity in the homogenate of periodontal tissues were multidirectional. Thus, in rats with periodontitis on the background of hyperthyroidism this index significantly increased by 13.9%, in rats with periodontitis on the background of hypothyroidism - decreased by 1.9 times compared to the control group. The activity of elastase in the homogenate of periodontal tissues in rats with periodontitis increased by 50.8%, in rats with periodontitis and hyperthyroidism by 92.3%, in rats with perio-dontitis and hypothyroidism by 73.2% compared to the control group. It has been concluded that experimental periodontitis is accompanied with the increase in elastase and urease activities and the decrease in lysozyme activity in the homogenate of periodontal tissues. These data indicate on the development of local inflammatory reactions, a pronounced degree of dysbiosis, and the decrease in the level of nonspecific protection. Imbalance of thyroid hormones strongly affects the course of periodontitis, especially in hyperthyroidism
Journal problems of biology and medicine -
Organ-preserving operations m echinococcosis oi the liver arc accompanied by a slight trauma to the liver tissue. It is the cases when the invasiveness of access exceeds the invasiveness of the intervention itself on the operated organ are indications for the use of minimally invasive, video endoscopic technologies. Minimally invasive video endoscopic techniques for treating liver echinococcosis significantly improve patient outcomes. With the accumulation of experience in performing these operations for an increasing number of patients with echinococcosis, the approaches will become optimal for performing surgery. -
Evaluation of metabolic changes in prolonged neonatal hyperbilirubinemia With c-reactive protein and procalcitoninThe article presents the causal mechanisms of prolonged neonatal hyperbilirubinemia. Modem methods for the study of inflammatory markers are described. Early markers of inflammatory activity with prolonged hyperbilirubinemia were analyzed.
Doctor's Herald -
Indicators of lipid peroxidation and their significance in pathogenetic mechanism of anaemic cardiomiopathyTo characterize the morphological and functional changes in the myocardium arising from the develop-ment of chronic iron-deficiency anemia the terms of «anemic heart» or anemic cardiomiopathy are used. For the purpose of the main pathogenetic mechanisms, in particular lipid peroxidation, 140 patients suffering from chronic anemia of varying degrees of severity and cardiomyopathy and 30 generally healthy individuals were studied. During the research it was identified that the main mechanisms stimulating the cascade of metabolic and morphofunctional changes in the heart of patient suffering from IDA are the indication of hemical hypoxia and activation of the processes of lipid peroxidation which lead to the decrease in antioxidant protection. In turn, the reduction of antioxidant protection leads to the intensification of production of pro-inflammatory cy- tokines which are involved in fibrillar collagen degradation and intensification of cardiomyocyte apoptosis, that causes cardiomiopathy
Journal problems of biology and medicine -
Effect of sorbilact and l-arginin on the status of cardiovascular system in the complex infusion therapy of endogenous intoxication syndrome of purulent-septic genezeThe effect of the combined use of sorbilact and L-arginine in the program of infusion therapy of the en-dogenous intoxication syndrome of purulent septic genesis on the state of the cardiovascular system was stud-ied.
Journal problems of biology and medicine -
Effect of kazein on lipolytic activity of the pancreatic juice with and without participation of bilic acidsWe studied the role of casein and its hydrolysates in the inhibition of lipase and its binding ability with bile acids, by changing the activity of pancreatic lipase and digesting fats. It was concluded that preliminary hydrolysis of pepsin proteins in the stomach not only further improves their hydrolysis under the influence of proteolytic enzymes of pancreatic juice (tryptic attack of proteins), but also reduces their binding capacity with bile acids and improves hydrolysis of fats under the influence of pancreatic lipase. This fact is probably more important for the hydrolytic function of the stomach than the tryptic attack of proteins in the stomach and the main evolutionary factor in the preliminary digestion of proteins with gastric juice.
Doctor's Herald -
Differential - diagnostic approach of the etiology and clinical symptoms of prolonged neonatal hyperbilirubinemiaAnalysis of the literature data shows the relevance and significance of prolonged neonatal hyperbilirubinemia in the present. Excessive accumulation of bilirubin in the serum of a newborn can become negative in the growth and development of the individual as a whole. The particularly toxic effect of bilirubin leads to such negative consequences as damage to the central nervous system, after which paresis, paralysis and even death in the neonatal period can occur. The primary condition for solving this problem is a differential diagnostic approach of the etiology and clinical symptoms of prolonged neonatal hyperbilirubinemia.
Doctor's Herald -
The article presents current data on the species diversity of vaginal lactobacilli and mechanisms that provide antimicrobial protection of the vaginal biotope. The colonization resistance of the vagina is supported by the dominance of lactobacilli with protective properties, exactly, L. crispatus и L. jensenii, the presence of the bacterium L. incrs, which at any moment can contribute to the manifestation of bacterial vaginosis. -
Features of structural alteration in periodontal complex components at the early stage of the experimental bacterial-immune periodonitis developmentThe inflammatory process in the periodontium is the most widespread among dental diseases, that is characterized by a recurrent course and significantly reduces the quality of life patients. Existing data about structural and pathomorphological changes in the tissues of the periodontal complex for the of inflammation development does not explain largely the patterns of the destructive phenomena development in this pathology. and therefore require additional research. The purpose of this study was to determine the peculiarities of struc- tural components of periodontal complex and their changes on the 7 th day of the experimental bacterial- immune periodontitis development. In the study of intact animals, it was found that connective tissue of its own plate is represented by collagen fibers, forms high connective tissue papillae and closely adheres to the epithe- lium. The histological study showed that on the 7th day of the experimental bacterial-immune periodontitis de- velopment of typical and spread inflammatory reaction onto all periodontium was observed. However, the se-verity of this reaction was different in the structural components of the periodontium. Fibroblasts were the most often found among cellular elements, less frequently – histiocytes, lymphocytes, single plasmacytes and mono-cytes. It was an increase of the fibroblasts number, that perform the resorptive functionof collagen fibers and reduce number of active osteoblasts. All these pathomorphological changes testified about of the inflammatory process development
Journal problems of biology and medicine -
The article analyzes the incidence of nosocomial infections (N1) in medical institutions (MI) of the Bukhara region in 2015. Purulent septic infections (PSI) have been shown to be the most common cause of MI. MI are characterized by high contagiousness, a wide range of pathogens and a variety of ways of their transmission, the possibility of outbreaks at any time of the year, the presence of patients with an increased risk of the disease (the so-called "risk group") and the possibility of recurrence.
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