All articles - Immunology
Number of articles: 112
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ASSESSMENT OF LOCAL AND HUMORAL IMMUNITY IN PATIENTS WITH CHRONIC PYELONEPHRITISThe article describes the relationship between the disease of chronic pyelonephritis and the state of the oral fluid by studying the changes in the level of pro-inflammatory and anti-inflammatory cytokines in various biological fluids of the body, in order to include in the subsequent differentiated immunocorrection of the combined form of the disease. We examined 68 patients with chronic pyelonephritis aged 25 to 65 years and older, with a disease duration of 3 to 10 years (of which 67.2% were women and 32.8% were men). It was revealed that the increased content of pro-inflammatory mediators IL-1, IL-6, IL-8 and TNF-a in the oral fluid of patients with CP can activate inflammatory and destructive processes and manifest themselves in the form of exacerbations of periodontal disease and oral mucosa.
Medicine and innovations -
Preeclampsia (PE) is an often fatal pathology characterized by hypertension and proteinuria at the 20th week of pregnancy, which affects 5-10% of pregnant women. This problem is especially important in developing countries, where the incidence of hypertensive pregnancy disorders is higher and maternal mortality rates are 20 times higher than in developed countries. Risk factors for PE include obesity, insulin resistance and hyperlipidemia, which stimulate the release of inflammatory cytokines and oxidative stress leading to endothelial dysfunction (ED). However, how all these clinical manifestations coincide with the development of PE is still not very clear. The associated poor trophoblast invasion and uteroplacental artery remodeling described in PE increase reactive oxygen species (ROS), hypoxia and ED. -
Premature birth occurs in about 20% of pregnancies [1]. In many developed countries, rates are rising. The problem of maternal and child health protection is of paramount importance for the formation of a healthy generation from the earliest period of life [2]. -
EXPERIENCE OF THE NATIONAL VACCINATION PROGRAM IMPLEMENTATION AGAINST HUMAN PAPILLOMA VIRUS IN THE REPUBLIC OF UZBEKISTANIntroduction. Cervical cancer is one of the most serious threats to women's health. This is the fourth most common cancer in women around the world. According to the forecasts of international experts (taking into account population growth and an increase of life span expectancy), the increase in the incidence and prevalence of cervical cancer will have made up 40% in developing countries and in economically developed countries - 11% by 2020. In the case of non-conducting timely measures for the prevention and treatment of cervical cancer, malignant neoplasms of the cervix will affect up to 1 million women annually after 2050 in the world. Aim of the study is primary prevention of cervical cancer by introducing vaccination to 9 years old girls of the Republic of Uzbekistan. Material and methods. The Gardasil MK vaccine was imported to the Republic of Uzbekistan in 2019. From October 21 to November 30, 2019, the first dose was vaccinated to 9 years old girls in the republic; the introduction of the 2nd dose is planned in 6 months. Results and discussion. Vaccination rates significantly increased after the measures taken on November 30: in the city of Tashkent - 97%, in the Tashkent region - 90.8%, in Bukhara - 90.2%. Refusers made up 66.9% of unvaccinated girls. Temporary left who also did not receive vaccination made up 360 (4%). 1935 girls were not vaccinated by other reasons and they made up 21.4% of the total unvaccinated population. Conclusion. As a result of joint efforts by the Government of the Republic of Uzbekistan, the Ministry of Health with the support of international organizations from WHO and UNICEF, the first dose of the tetravalent HPV vaccine - Gardasil MK- was successfully administered to 9 years old girls all over the country. According to the data of Health Ministry of the Republic of Uzbekistan no adverse reactions were observed in 292,867 girls after vaccination.
Doctor's Herald -
CHANGES IN IMMUNOLOGICAL INDICATORS AND PROTEASIS INHIBITORS IN WOMEN IN EARLY PREGNANCYThe work studied changes in immunological parameters and protease inhibitors in women without infections and with an infection of the genitourinary system in the early stages up to 12 weeks of pregnancy. It was concluded that the presence of infectious factors in the absence of a significant proinflammatory immune response in early pregnancy and a sufficient corrective reaction of protease inhibitors and TGF-01 may contribute to a favorable course of early pregnancy and the development of a full-fledged pregnancy. Therefore, studies of pro-inflammatory (TNF-u. IL-10) and anti-inflammatory interleukins (IL-10), as well as protease inhibitors (a -1-anti-trypsin) and TGF-01 can be used as markers of the adequacy and degree of correction of the immune system at early stages, terms of pregnancy.
Doctor's Herald -
ASSESSMENT OF MORPHOMETRIC CHANGES OF THE UPPER RESPIRATORY TRACT IN PATIENTS WITH GNATIC FORM OF OCCLUSION ANOMALYThe study involved 34 patients with gnathic forms of occlusion anomalies (GFOA) whom were conducted reconstructive operations on the jaws at the department of pediatric maxillofacial surgery at the clinic of TSDI. On the basis of complaints and anterior active rhinometry (PARM). the state of nasal breathing was studied. According to the results of PARM. in 79.2% of patients the condition of nasal obstruction (NO) associated with structural changes in the jaws. In order to influence the structural component of the NO surgical intervention is required. When drawing up a plan for the integrated treatment of patients with GFOA. it is necessary to take into account the severity of NO for prevent disruption of the functioning of various organs and systems.
Stomatologiya -
In the progression of diabetic nephropathy, considerable attention is paid to the development of anemia. Л significant reason for the development of anemia in patients with diabetes mellitus (DM) with diabetic nephropathy is a decrease in the production of erythropoietin in the peritubular cells of the proximal nephron. Anemia predominates in patients with diabetic nephropathy, it is associated with cardiovascular disease, retinopathy. Anemia begins to develop long before the violation of the filtration function of the kidneys. -
ASSESSMENT OF IMMUNE STATUS AND EFFICIENCY OF IMMUNE CORRECTION OF INFLAMMATORY DISEASES OF THE PELVIC ORGANS IN WOMENThe aim of the study was to review and analyze the literature on the definition and condition of the immune system and the effectiveness of immune corrective measures. It was found that in acute and chronic IDPO (inflammatory diseases of the pelvic organs) the development of secondary immunodeficiency was noted, expressed by a decrease in the indicators of cellular and humoral immunity, multidirectional changes in pro- and antiinflammatory cytokines in patients. Almost all authors were unanimous in the opinion that immune corrective therapy should be used for inflammatory diseases of the pelvic organs, while offering various immune correctors.
Doctor's Herald -
The aim of the work was to assess the state of the immune system of children with out-of-hospital pneumonia, comparative analysis of the main parameters of the immune system show ed that the inclusion of an immunocorrec-tor for bronchomunal according to the scheme contributes to a more positive clinical and immunological dynamics, correcting the broken links of immunity. -
Characteristics of the immune status of patients with the combined course of their chronic cholecystitis and metabolic syndromeThe immunometabolic features of the comorbid chronic cholecystitis and metabolic syndrome were studied. 82 patients with chronic cholecystitis and metabolic syndrome were examined. A feature of the comorbid metabolic syndrome and chronic cholecystitis is the increased activity of systemic inflammation, which is reflected in increased production of the proinflammatory cytokine tumor necrosis factor-а (TNF-a), a soluble receptor for it ((sTNF-a RI)) and pronounced changes in all parts of the immune system.
Doctor's Herald -
Postnatal formation of peripheral organs of the immune system of offspring under the influence of pesticides through the mother's organismThe purpose of the work is to reveal the structural and functional features of postnatal growth and the formation of peripheral organs of the immune system of offspring obtained under the influence of pesticides through the mother's organism. The experiments were performed on white adult female rats, who respectively received pesticides lambda-cyhalothrin or fipronil during pregnancy and lactation. Progeny from experimental and control animals was studied on the 3rd, 7th, 14th, 21st and 30th days after birth using methods of mor-phology, electron microscopy, mmunohistochemistry and biochemistry. It has been shown that the toxic effect of pesticide exposure during pregnancy and lactation is manifested in the form of growth retardation and for-mation of the peripheral immune organs – lymph nodes and spleen. In the mechanism of toxic effect of pesti-cides on the peripheral immune system the leading role is played by the imbalance between proliferation and apoptosis of cells, caused both by direct toxic effects of drugs, both developing hypothyroidism and oxidative stress in mother and offspring. This causes the need for early detection of hypothyroidism and oxidative stress in pregnant women and newborns, followed by their pharmacological correction
Journal problems of biology and medicine -
Violation of the immune system in patients with ulcerative Stomach disease and its correction in the process of treatmentThe immune status was studied in 34 patients with ulcerative stomach diseases (USD) and in 36 healthy individuals. Impaired immune status was noted in patients with USD, which was manifested in a deficiency of T- and B-links of the immune system, and a deficiency in the parameters of humoral immunity. The use of thymoptinum against the background of basic treatment led to the correction of the basic parameters of cellular immunity, an increase in IgG production. Thimoptinum eliminated immunological deficiency in patients with USD.
Doctor's Herald -
The article investigated the condition of local immunity in the oral cavity in 48 patients with chronic recurrent aphthous stomatitis (CRAS). Patients with CRAS showed a decrease in the level of lysozyme and slgA in the oral liquid (OL), which is an unfavorable prognostic criterion in patients with CRAS. This undoubtedly affects the course of the pathology in patients with CRAS. Low values of lysozyme and slgA can lead to impaired microbiocenotic status and reduced functioning of the oral mucosa (OM) in patients with CRAS. -
Changes of activity of neutrophils of blood at experimental bacterial and Immune periodontal disease and their correction by flavonolThe purpose of the study was to evaluate the activity of neutrophils in the blood under the condition of the experimental bacterial-immune periodontitis and to clarify the effect of flavonol quercetin on its parameters. The article presents the results of research on the indices of the spontaneous and activated test with nitrosin tetrazolium on the 14th day of the experimental bacterial-immune periodontitis and after correction with quercetin (in the same period of the experiment). In this case, data on the nature of changes in neutrophilic activity in the process of formation of inflammatory focus in the periodontal complex are given. The use of flavonol quercetin, which, acting on the immune processes, limited the inflammatory response in the periodontal tissues and led to a decrease in neutrophil activity relative to the rates of animals that did not receive the drug. As a result of the use of quercetin, the activity of neutrophils approached the values of the control group.
Doctor's Herald -
Variants of immunocorrection of correlation of the immune status at often ill childrenThe indices of three classes of immunoglobulins (A, M, G) and staphylococcal antitoxin were studied in 146 often ill children, from 1 year to 6 years old, hospitalized in pulmonology department of BD № 1 in Samarkand. Of these, 46 were treated by the traditional method (T), 50 by the traditional method using Broncho-munal (ТВ) and 50 by the traditional method using Bronho-munal and Sodium Nuclcinatc adjuvant (TBN). Studies were conducted before treatment (146) and in dynamics before discharge from the hospital (146). The effectiveness of the method is manifested by faster periods of clinical recovery, increased protective abilities of nonspecific factors, immune status with the appearance of antitoxic immunity and the duration of remission.
Doctor's Herald -
Features of damage of internal organs in patients with systemic lupus eritema- Tosus living in the cutting of continental climatic conditionsExplicit clinical symptoms of heart failure in systemic lupus erythematosus arc found in 51.4% of patients. Lung damage in SLE is often indicated as an infectious complication due to immunosuppressive therapy, especially long-term treatment with large doses of corticosteroids, rather than as a result of the severe course of the disease itself. Frequent symptoms of damage to the nervous system were sleep disturbances, which manifested itself in the form of lengthening the time of falling asleep, reducing the depth and duration of night sleep, rapid awakening and daytime sleepiness. Uncontrolled activity of the lupus process caused the appearance of severe manifestations, such as pneumonitis, pleurisy and pericarditis (scrositcs and polyscrositcs) and vasculitis.
Doctor's Herald -
The use of immunocorrective therapy for the treatment and prevention of diseases in children who are often illThe problem of chronically ill children is one of the most urgent and unsolved problems in pediatrics. We identified specific abnormalities in certain parts of the immune system and non-specific defense of the organism in FIC, which is the basis for inclusion immunocorrective drugs for the treatment and prevention of diseases. Use as drug immunocorrective Broncho-Munal reduces the incident of disease and improve quality of life of ill children.
Doctor's Herald -
This article presents data from a survey of children with recurrent respiratory diseases. Vitamin D deficiency has been established, which can be considered as one of the etiological factors of frequent respiratory morbidity in children, low vitamin D levels are found in 80% of cases. -
Тhe use of the drug hemolif in the cure of iron-deficiency anemiaTreatment of iron-deficiency anemia is carried out according to the etiopathogenetic condition. If possi-ble, the causes of the disease are eliminated by an etiological factor that promotes the development of anemia. Pathogenetic method of cure is the appointment of iron preparations. In this work, characteristic of the medi-cine "Hemolif" is given, which was used in 30 patients who were on cured at the Research Institute of Hema-tology and Blood transfusion with the iron-deficiency anemia diagnosis in heavy degree. The positive effect of the Hemolif action is due to the iron (III) content of the hydroxide of the sucrose complex, stimulates erythro-poiesis and leads to an increase in the hemoglobin level
Journal problems of biology and medicine -
Dynamics of cellular immunity formation in small-weight children with animal dependence on the duration of gestationPurpose. The study of cellular and humoral immunity in premature infants. Material and methods. 90 premature babies born on the gestational age of 28-37 weeks. Methods of research are immunological, statisti-cal. Results. The state of the immune system in premature infants depends directly on the gestational age. The shorter the gestation period, the more pronounced manifestations of the decrease in the links of the immune status. Conclusion. Deficiency of immunoglobulin A is due to the immaturity of the undernourished child, but also the direct effect of its action on the sub-gastric gland
Journal problems of biology and medicine -
Molecular-genetic markers and features of the course of chronic hcv infection in UzbekistanThe aim of the study was a comparative analysis of the genotypic variants of the TNF-α and CTLA-4 genes in patients with chronic hepatitis C and liver cirrhosis and their effect on the course of the disease. The analysis of the influence of the genotypes of the TNF-α gene on the course of the disease indicates an increased risk of CVD with both moderate and highly active course of the disease in carriers of the combination of geno-types G / A + A / A. The obtained data allow us to conclude that the carriage of the allele "G" and the combina-tion of the A / G + G / G genotypes of the -49GG polymorph of the CTLA-4 gene are associated not only with a decrease in the risk of development of HCVF, but also with a lower intensity of inflammation and fibrosis in the liver and a high probability favorable course of the disease.
Journal problems of biology and medicine -
Study of the immune condition of the frequently sicked children invalid against hibHaemophilus influenzae type b is one of the common causes of generalized infection (bacteremia) in children, half of them developed purulent meningitis, quite often (15-20%), pneumonia, and rarely other focal lesions. In countries where the vaccination campaign against Hib-infection, there is a decrease in morbidity and frequency carrier Hib. Vaccination, in these countries, has led to a decrease in carrier frequency in a population of healthy children up to 0.5-1.0%. However, vaccination coverage of infants, vaccine efficacy ACP-Hib, preservation of antibody titer in the infection and their comparison with the reduction of morbidity during the vaccination have not been investigated. Figuring allow them to improve preventive measures in organized and unorganized babies on Hib-infection and to assess their cost-effectiveness. All of the above was the object of study
Journal problems of biology and medicine -
Immunopathogenetic course featuresrelapsing forms of genital herpes
Journal problems of biology and medicineImbalance of humoral immunity, accompanied by high-Coy concentration of the CEC, can be evaluated as stressful type of response with the subsequent depletion of adequate reaction of the or-ganism
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There was data on the clinic of polyradiculoneuritis as early as the middle of the 19th century, the exact localization of their foci was unknown. However, the lesion occurs in the central nervous system (CNS). In 1864, Dumesnil recorded the observation of transient paralysis as a result of damage to the peripheral nerves. In addition, Landry also made independent clinical observations. Histopathology of polyradiculoneuritis before 1880 Although data were not available, a group of researchers led by Deger studied the pathological causes of diphtheria paralysis. In the same year, Gombo developed an experimental model for the demyelination of peripheral nerves. Of lead and arsenic poisoning, diabetes, leprosy, alcoholism, and beriberi also cause nerve damage and paralysis [2, 5, 11, 23, 29]. -
Level immune response mediators in children with epilepsy the background cerebral palsyA study of 85 children with epilepsy or without at cerebral palsy background to study the level of pro-inflammatory (TNF-α and IFN-γ) cytokines in the serum and cerebrospinal fluid. It was revealed that the pe-ripheral blood serum of children with cerebral palsy TNF-α level by almost 3 times higher than control group values, and IFN-γ level is 1.3 times lower than control values. In children with cerebral palsy with epilepsy on a background level of TNF-α is 1.5 times higher than the control group values, and 1.7 times lower than that of children with cerebral palsy without epilepsy, and the level of IFN-γ in the presence of epilepsy is 1.7 times lower control values. In the cerebrospinal fluid of children with cerebral palsy and epilepsy level of TNF-α was significantly higher than in children without epilepsy
Journal problems of biology and medicine
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