Study Of The Neuroprotective Properties Of Biologically Active Compounds
Keywords:
Abstract
The works show that, using fluorescent probes, it was used to study the effect of PC-8 on changes in the dynamics of the intracellular Ca2+ content in synaptosomes of the rat brain, depending on the site of the binding of glutamate on calcium channels by a specific mediator with glutamate. To measure the amount of cytosolic Ca2+ synaptosomes, we calculated using the Grinkevich equation. It has been shown that polyphenol PC-8 binds to the glutamate-binding site of NMDA receptors, so that the conductance for Ca2+ ions is reduced through a channel blocking the effect of polyphenol PC-8 can be explained. due to its binding to the competing action of the site, the binding of glutamate to NMDA receptors.
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References
P.K. Kamat, S. Rai, S. Swarnkar, R. Shukla, C. Nathт. Mechanism of synapse redox stress in Okadaic acid (ICV) induced memory impairment: role of NMDA receptor. Neurochem. Int., 76 (2014), pp. 32-41.
S. Rai, P.K. Kamat, C. Nath, R. Shukla. Glial activation and post-synaptic neurotoxicity: the key events in Streptozotocin (ICV) induced memory impairment in rats. Pharmacol. Biochem. Behav., 117 (2014), pp. 104-117
Khoshimov N.N., Rakhimov R.N., Akhmedova G.B., Azizov V.G. Investigation of the effect of polyphenol euphorbin on the transport of L Glutamate and calcium channels to synaptosomes of rat brain // European Journal of Medicine. – 2018. – №. 6. – С. 72-82. DOI: 10.13187/ejm.2018.2.72
M. Nilsson, D. van Westen, F. Stahlberg, P.C. Sundgren, J. Latt. The role of tissue microstructure and water exchange in biophysical modelling of diffusion in white matter. Magma, 26 (2013), pp. 345-370.(New York, NY)
Q.K. Telesford, S.L. Simpson, J.H. Burdette, S. Hayasaka, P.J. Laurienti. The brain as a complex system: using network science as a tool for understanding the brain. Brain Connect, 1 (2011), pp. 295-308.
Khoshimov N.N., Saidmurodov S. A., Rakhimov R.N. (2021). The Mechanism of action of polyphenol on changes in the dynamics of calcium in the synaptosomes of the rat brain against the background of glutamate. The American journal of applied sciences, 3(03), 48-55. https://doi.org/10.37547/tajas/Volume03Issue03-08
S. Chanraud, N. Zahr, E.V. Sullivan, A. Pfefferbaum. MR diffusion tensor imaging: a window into white matter integrity of the working brain. Neuropsychol. Rev., 20 (2010), pp. 209-225.
Кhoshimov N.N, Nasirov K.E., Rakhimov R.N. The Research of action of preparations rutan and gossitan on the glutamate eksitetoxic mediated by NMDA-receptor at chronic alcoholic intoxication and cancellation of ethanol // Russian Journal of Biological Research, 2015, Vol. (4), Is. 2. Page 60-67.
J.A. Autio, R.E. Roberts. Interpreting functional diffusion tensor imaging. Front. Neurosci., 8 (2014), p. 68.
Khoshimov N.N., Nasirov K.E. Action of cytisinum on the transport mediators and calcium channel of glutamatergic neurotransmitter systems of the NMDA-receptor. European Journal of Medicine. 2017, 5(2): 56-63. DO- 10.13187/ejm.2017.2.31.
Vauzour D. Dietary polyphenols as modulators of brain functions: biological actions and molecular mechanisms underpinning their beneficial effects. Oxid Med Cell Longev. 2012;2012:914273. doi:10.1155/2012/914273.
Khoshimov N.N; Raimova G.M.; Nasirov K.E.; Rakhimov R.N.; Azizov V.G. The effect of SP-6 on the transport of mediators of NMDA-receptors and Ca2+-channels in synaptosomes of rat brain. ”European Journal of Molecular & Clinical Medicine”, 7, 3, 2020, 2435-2446.
"European Convention for the Protection of Vertebrate Animals used for Experimental and other Scientific Purposes." Strasbourg. 1986. Available from: http://conventions.coe.int
Weiler, M. H., Gundersen C. B. and Jenden D. J. (1981) Choline uptake and acetylcholine synthesis in synaptosomes: Investigations using two differently labelled variants of choline//Neurochem. 36. P.1802-1812.
Grynkiewicz G., Poenie M., Tsien R.Y. 'A new generation of Ca2+, indicators with greatly improved fluorescence properties' J. Biol. Chem. Vol. 260, 1985, P. 3440 – 3450.
