A Retrospective Study Of The Clinical Significance Of Hemoconcentration As An Early Prognostic Marker For The Development Of Severe Acute Pancreatitis
Keywords:
Abstract
Objective: to study the relationship between hematocrit indicators during the first 6 hours after the patient's hospitalization and the development of complications of acute pancreatitis.
Materials and methods. The study included 243 patients with acute pancreatitis. All patients were examined for hematocrit at admission. The multivariate analysis made it possible to determine whether there was a correlation between the presence of hemoconcentration in patients (hematocrit ≥43) at the time of admission with the development of complications of acute pancreatitis. The predictive effectiveness of this marker was estimated by the area under the ROC curve.
Results. Severe acute pancreatitis was observed in 36 (14.8%) patients. Average hematocrit values were 43.2 ± 6.4% (P0,01). In the first 6 hours after admission, hemoconcentration was observed in 72.2% of patients with acute pancreatitis who later developed complications of this disease.
Similar Articles
References
Gubergrits NB, Lukashevich GM, Fomenko PG, Beliaeva NV. "Fatal chain": from acute pancreatitis to pancreatic cancer. Herald of Pancreatic Club. 2017; 36(3):16-30. (inRuss.).
Guerrero A., de Miguel A.F., Albillos A. Acute pancreatitis. Diagnostic and therapeutic protocol. Medicine. 2019; 87(12):5140-5144. DOI: 10.1016/j.med.2019.10.008
Lankisch P.G., Apte M., Banks P.A. Acute pancreatitis. Lancet. 2015; 9988(386):85-96. DOI: 10.1016/S0140-6736(14)60649-8
Leppäniemi A., Tolonen M., TarasconiА., Segovia-Lohse H., Gamberini E., Kirkpatrick A.W., et al. 2019 WSES guidelines for the management of severe acute pancreatitis. World Journal of Emergency Surgery. 2019; 14:27-39. DOI: 10.1186/s13017-019-0247-0
BagnenkoSF, GoltsovVR. Acute pancreatitis - the current state of the problem and unresolved issues. AlmanacoftheVishnevskyInstituteofSurgery. 2008; (3)3:104-112. (inRuss.).
Jeon T.J., Lee K.J., Woo H.S., Kim E.J., Kim Y.S., Park J.Y., et al. Refeeding Syndrome as a Possible Cause of Very Early Mortality in Acute Pancreatitis. Gut and Liver. 2019; 13(5):576-581. DOI: 10.5009/gnl18458
Valverde-López F., Matas-Cobos A.M., Alegría-Motte C., Jiménez-Rosales R., Úbeda-Muñoz M., Redondo-Cerezo E. BISAP, RANSON, lactate and others biomarkers in prediction of severe acute pancreatitis in a European cohort. Journal ofGastroenterology and Hepatology. 2017; 32:1649–1656. DOI: 10.1111/jgh.13763
Doctor N., Agarwal P., Gandhi V. Management of severe acute pancreatitis. Indian Journal of Surgery. 2012; 74(1):40-46. DOI: 10.1007/s12262-011-0384-5
Gao W., Yang H.X., Ma C.E. The Value of BISAP Score for Predicting Mortality and Severity in Acute Pancreatitis: A Systematic Review and Meta-Analysis. PLoS One. 2015; 10(6):e0130412. DOI: 10.1371/journal.pone.0130412
Mayerle J., Sendler M., Hegyi E., Beyer G., Lerch M.M., Sahin-Tóth M. Genetics, Cell Biology and Pathophysiology of Pancreatitis. Gastroenterology. 2019; 156(7):1951-1968.
