CURRENT APPROACHES AND NEW RESEARCH IN
MODERN SCIENCES
International scientific-online conference
140
MORPHOLOGICAL CHANGES OF THE SPLEEN IN EXPERIMENTAL
RHEUMATOID ARTHRITIS WITH THE HELP OF ADJUVANT
FREYEND
Makhmudova Guljamol Fazliddinovna
Azimova Dilora Alijonovna
Bukhara State Medical institute named after Abu Ali ibn Sina
https://doi.org/10.5281/zenodo.13923404
Research relevance:
the immune system is one of the most complex
autonomous regulatory systems of the div, therefore, violation of its
functionality leads to serious complications of an autoimmune and infectious
nature. “In this regard, in recent years, the issues of maintaining homeostasis in
the immune system have become especially relevant.”The protection of a living
organism cannot be imagined without an immune system. In humans and
animals, the immune system provides the div's flexibility and protection
against the effects of various pathogenic factors. In recent years, there has been
an increase in diseases associated with damage to the immune system in the
world". Currently, the degree of the div's immune reactivity undoubtedly
determines the course and consequences of most diseases. The state of health of
modern society is characterized by a decrease in immune reactivity,as a result,
an increase in acute and chronic diseases.". In the world, a number of scientific
studies are being carried out aimed at assessing the changes in morphological
and morphometric indicators of the spleen under the influence of rheumatoid
arthritis disease and auxiliary Freund induced arthritis. In this regard, it is
required to substantiate age-related normative, rheumatoid arthritis and
morphological and morphometric indicators of the spleen of white-breed rats in
postnatal ontogenesis, to compare morphometric indicators of spleen lymphoid
structures in rheumatoid arthritis with indicators of healthy laboratory animals,
to study morphological and morphometric changes that occur in their spleen
when administering rheumatoid in arthritis.
The purpose of the study.
Study of morphological, morphometric and
immunogystochemical indicators of the White Rat spleen in the treatment of
experimental rheumatoid arthritis and postpatogenetics.
Materials and methods:
for the modeling of rheumatoid arthritis, a full-
fledged Freund assistant was used in 100 white randomized rats aged 18 to 24
months under the stationary conditions of the vivarium of the Bukhara State
Medical Institute.
CURRENT APPROACHES AND NEW RESEARCH IN
MODERN SCIENCES
International scientific-online conference
141
Results:
age-related morphological and morphometric changes are justified
in postnatal ontogenesis in the White Rat spleen after rheumatoid arthritis and
under the influence of the adyuvant Freyend
.
The study of structural changes in
postnatal ontogenesis of the White Rat spleen in rheumatoid arthritis disease
and under the influence of Freyend's blanket is based on the possibility of
determining the most dangerous age periods;
The data obtained in the study is based on the fact that it is important to identify
the development of immunopathological processes that occur under the
influence of rheumatoid arthritis in the early stages, to prevent it and to develop
effective treatments.
References:
1.
Г Махмудова// ВЛИЯНИЕ РАЗЛИЧНЫХ ФАКТОРОВ НА ЛИМФОИДНЫЕ
СТРУКТУРЫ СЕЛЕЗЕНКИ// Центральноазиатский журнал образования и
инноваций.- Vol-3. Issue-1. C.-122-130.-2024
2.
G Makhmudova, A Nurboboyev//INFLUENCE OF VARIOUS FACTORS ON
THE LYMPHOID STRUCTURES OF THE SPLEEN//Центральноазиатский
журнал образования и инноваций.- Vol-3. Issue-1. P.-131-138.-2024
3.
М Турдиев, Г Махмудова// ТУРЛИ ОМИЛЛАРНИНГ ТАЛОҚ ЛИМФОИД
ТУЗИЛМАЛАРИГА ТАЪСИРИ//Центральноазиатский журнал образования
и инноваций.- Vol-3. Issue-1. B.-139-147.-2024
