13
FEATURES OF THE COURSE OF PULMONARY HYPERTENSION
IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE
Anvarov A.Kh., Medical-pedagogical and medical faculty, 602-group
medical pedagogy
Scientific supervisor: assistant Shamukhamedova N.Sh.
Department of Internal Diseases, Nephrology and Hemodialysis.
Relevance:
The problem of COPD occupies one of the leading places in clinical medicine,
which is due to both the steady increase in morbidity and the frequent development of
complications, in particular, CHL.
Objective:
to study the course of pulmonary hypertension in patients with chronic
obstructive pulmonary disease (COPD).
Material and methods:
The study is based on the examination data of 60 patients aged 35-
78 years with COPD of I—III severity. To determine the severity of the course of LH in patients,
the definition of functional class was used (FC; WHO/NYHA, 2003). All patients with COPD
were examined according to a single program, which included anamnesis, objective data,
laboratory and instrumental methods of examination. Clinical and laboratory examination of
patients, including clinical and biochemical blood tests, general urine analysis, ECG, chest
radiography were performed according to generally accepted methods.
Results:
According to the data obtained, among all COPD patients, signs of LH were
diagnosed in 31.7% of patients and in 77.4% corresponded to I, in 16.1% - II and in 6.5% - III
degree of LH. In this group of patients, LH corresponded to II and III FC and was detected in
severe and extremely severe course of the underlying disease. Analysis of the clinical
manifestations of LH depending on its severity in the group of patients with COPD revealed
signs that were more often diagnosed with an increase in the degree of LH.Severe pulmonary
hypertension was registered in 6.5%. For all COPD patients with severe pulmonary
hypertension, a significant decrease in lung diffusion capacity, severe hypoxemia without
hypercapnia and a moderate decrease in FEV1 are considered typical functional features.
Conclusions:
Thus, pulmonary hypertension in COPD is characterized by lower values of
mean blood pressure than in primary pulmonary hypertension, reaching a level of 40-50 mm Hg.
It occurs due to pulmonary vasoconstriction as a result of alveolar hypoxia, acidosis and
hypercapnia, due to mechanical pressure of increased lung volume on the pulmonary vessels, a
decrease in the number of small vessels from-due to emphysema and destruction of the alveoli,
as well as as a result of increased cardiac output and increased blood viscosity due to
compensatory polycythemia (due to hypoxia).
References:
1.
Абдурахманова
,
Ф
.
Р
.,
К
.
Ш
.
Салихова
, and
Н
.
Д
.
Ишниязова
. "
ЗНАЧИМОСТЬ
ОПРЕДЕЛЕНИЯ С-РЕАКТИВНОГО БЕЛКА И ЦИТОКИНОВ У НОВОРОЖДЕННЫХ С
ВРОЖДЕННОЙ ПНЕВМОНИЕЙ
."
Российский вестник перинатологии и педиатрии
66.4
(2021): 278-278.
