Genetics and Heredity

Монография посвящена аутоиммунным полиглаидулярным синдромам (АПС), которые в настоящее время являются одной из актуальных проблем эндокринологии. АПС - редкая полиэндокринопатия, которая характеризуется поражением нескольких эндокринных желез и неэндокринных тканей в результате иммунных нарушений. Обычно это приводит к снижению активности участников. Скрининг, диагностика, иммуногенетическое, эпидемиологическое и клиническое изучение АПС является одним из актуальных направлений современной эндокринологии.
Монография расчитана для врачей- эндокринологов, клинических ординаторов, резидентов и студентов медицинских вузов

In children, glomerulonephritis is a disease characterized by rapid progression and complication caused by an irreversible process of the renal glomeruli. Currently, methods of molecular diagnostics have begun to actively develop, which not only complement traditional research methods, but also provide insight from the point of view of molecular pathophysiology. It is expected that a key role in the diagnosis of kidney disease is played by the identification of genes and their changes in the course of the disease, which predict the course of the disease. Changes in chromosomal polymorphic genes of matrix metalloproteinase and its tissue inhibitors, as well as how this change manifests itself in chronic glomerulonephritis, were determined in the prognosis of the disease.

The thyroid gland (glandula thyroidea) is an unpaired endocrine organ whose function is regulated by the central nervous system and the thyroid-stimulating hormone of the anterior pituitary gland.

The gland is located in the region of the anterior triangle of the neck (trigonum cervicale anterius), bounded from above by the base of the lower jaw, from below by the jugular notch of the sternum, on the sides by the anterior edges of the right and left sternocleidomastoid muscles.

Among infectious diseases of childhood, the most common, after acute respiratory viral infections, is acute intestinal infections. We were interested in the question whether there is an antigenic relationship between the Escherichia coli of a mother and her children - members of the same family. We assumed that the E. coli of children who are related to each other on the maternal line must have an antigenic connection. In this work, we present materials confirming this position. The research was conducted in 2 stages. At the first stage, we studied the presence of an antigenic link between the Escherichia coli of mothers and their newborns. As well as how long the antigenic link between the Escherichia of mothers and their children persists. Finding out this question is the second stage of our research.

Early diagnosis of Myeloproliferative diseases (MPD) is one of the serious problems of oncohematological practice. MPD efers to multifactorial diseases, the development of which is influenced by both environmental factors and genetic predisposition. The study studied the association of the carriage of the genotype for the polymorphic marker encoding glycoprotein-P and the development of MPD. The homozygous T / T genotype of the rs1045642 polymorphism of the MDR1 gene is a significant determinant of the increased risk of developing MPD in Uzbekistan (P<0.05). Conclusion. Genotype association the rs1045642 polymorphism of the MDR1 gene is associated with the risk of developing MPD.