American Journal Of Social Sciences And Humanity Research
117
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VOLUME
Vol.05 Issue05 2025
PAGE NO.
117-121
10.37547/ajsshr/Volume05Issue05-28
The Use and Effectiveness of Therapeutic Red Echinacea
In the Complex Treatment of Chronic Recurrent
Aphthous Stomatitis in Patients with Chronic
Gastroduodenitis
INDIAMINOVA Gavkhar Nuriddinovna
Doctor of Philosophy medical sciences (PhD), Samarkand State Medical University, Uzbekistan
Received:
28 March 2025;
Accepted:
24 April 2025;
Published:
26 May 2025
Abstract:
Objective: to increase the effectiveness of treatment of chronic recurrent aphthous stomatitis of the
oral mucosa against the background of chronic gastroduodenitis by correcting dysbiotic disorders and enhancing
antioxidant protection through pathogenetic therapy.
Methods: General clinical, laboratory, biochemical, functional, instrumental and statistical methods were used in
the course of the study.
Results: Clinical studies in patients with chronic recurrent aphthous stomatitis of the oral mucosa against the
background of chronic gastroduodenitis have shown: a decrease in the following indicators by 1.24 times, a
deterioration in hygiene by 1.92 times, an increase in the Schiller-Pisarev test by 2.06 times, an increase in
stimulated salivation by 1.84 times and the absence of stimulated salivation by 2.09 times, a shift in The pH is in
the acidic side.
Conclusions: The results of clinical and laboratory studies during operative and long-term follow-up showed that
the therapeutic and prophylactic complex developed by us for the treatment of oral mucosal diseases in chronic
gastroduodenitis has a long-term bactericidal effect against pathological microbes. The local immune status of
the oral cavity was observed to approach the norm.
Keywords:
Chronic recurrent aphthous stomatitis, dental caries, periodontal diseases, epidemiological study,
chronic aphthous stomatitis, oral mucosa.
Introduction:
it has been proven that in patients with
gastroduodenitis, the activity of the intestinal
microflora decreases and the activity of intestinal
enzymes decreases. As a result of a violation of
normomicrobiosis in the div, intestinal dysbiosis
occurs, in which the intestinal microflora degrades,
which leads to disruption of the normal functioning of
the intestinal biocenosis. This substance has anti-
inflammatory and antioxidant effects, and also has
anti-inflammatory and anti-inflammatory effects on
the div, which contributes to the development of
cancer. Activation of coagulase, a precursor to
dysbiotic bacteria such as staphylococci, hemolytic
streptococci, lactobacilli, corynobacteria, aerobic
gram-positive bacteria (pathogenic fungi) and
nematode fungi.adventurous and forced to be a normal
Florentine shepherd. The presence of pathogenic
microflora in the oral cavity leads to aphthous
stomatitis (sepsis).
The examination revealed that 30% of patients with
chronic dental disease had caries, and 60% of patients
with chronic dental disease had recurrent stomatitis.
Due to increased sensitivity to the effects of microflora,
antibacterial therapy and the irrational use of
antifungal and antifungal agents in conditions of
increased risk of recurrence of inflammatory lung
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American Journal Of Social Sciences And Humanity Research (ISSN: 2771-2141)
diseases, it is possible that this will lead to a
deterioration in the well-being of patients.
The methods of diagnosis of stomatitis developed by
him, based on the study of cervical pathologies, as well
as the pathogenetic mechanisms of the development
of such complications, have significantly expanded the
horizons of patients.We believe.
A special role in the development of malignant
neoplasms is played by exo- and endogenous malignant
neoplasms -biological enzymes of substrates, Haus,
naphthalene enzymes and their specific reactions of
inhibition of ultraviolet rays. "distress"), that is, as a
stress agent.
Due to the fact that people with hearing impairments
do not have teeth and gums, they may be at risk of
developing diseases characterized by increased
sensitivity to UV rays. This suggests that the tooth
pathology is flagellated, may be chronic, or may be
related to the sensory response of the entire organism.
One of the main areas of research in dentistry is the
study of pathologies and concomitant diseases of the
gums and gums, the study of the regulation of gum
homeostasis and the regulation of the regulation of
homeostasis in the div.in this regard, periodontal
diseases may develop an inferiority complex.
In modern dentistry, there is no single approach to the
diagnosis and treatment of aphthous stomatitis, unlike
most other diseases, including dental diseases, which
are not independent and are not associated with
certain physical and social needs.
The etiology of gastroduodenitis in children and
adolescents with disabilities includes the following
areas of therapy: drug therapy; drug therapy for
gastroduodenitis;
drug
therapy
for
acute
gastroduodenitis;
drug
therapy
for
acute
gastroduodenitis;
drug
therapy
for
acute
gastroduodenitis;
drug
therapy
for
acute
gastroduodenitis;
drug
therapy
for
acute
gastroduodenitis; therapy for acute gastroduodenitis.
and pathogenetics
The aim of the study was to identify increased levels of
dysbiotic cholinergic receptors and pathogenetic
therapy using antioxidants in patients with
gastroesophageal gastroduodenitis.
METHODS
Materials and methods of tadiiotdacha: we used
tadiiotdacha methods to complete the tasks. Clinical
features of the development of gastroduodenitis in
patients with chronic gastroduodenitis not stimulated
by oral fluids, biochemical studies, microbiological
studies. To achieve this goal, 118 patients aged 24 to 56
years were examined: 70 of them were men and 48
were women. 118 people worked in the clinic (Table 1).
Of these, 34 Nafarians are patients with somatic
pathology,
84
Nafarians
are
patients
with
gastroduodenitis. The diagnosis of "gastritis and
duodenitis", K29.9 with the HCT-10 code was made by
gastroenterologists
based
on
a
history
of
gastroduodenitis.
The first (antisocial) survey conducted by People
magazine consisted of 46 people (25 men and 21
women) suffering from aphthous stomatitis and rare
gastroduodenitis. For the treatment of aphthous
stomatitis, anti-aging products are used, that is,
products containing antibiotics, antiseptics, antiviral,
bactericidal and antiviral drugs, keratoplasty.
Journalists have found out that in patients suffering
from gastroduodenitis, special pressure algorithms can
be used in the treatment of aphthous stomatitis in the
anamnesis (see Fig.1). One of the most well-known and
scientifically proven theories is the immunological
concept of the pathogenesis of this pathology.
Depending on the severity of the disease,
immunomodulatory therapy is prescribed. One of the
methods of immunomodulation is to enhance the
immune response in case of bacterial infection with
lipopolysaccharides. Bacterial lysosomes include the
immune system.
The second (comparative group) - 38 patients (24 men
and 14 women) with chronic recurrent aphthous
stomatitis
of
the
oral
cavity
and
chronic
gastroduodenitis were treated according to generally
accepted (traditional therapy) norms. Patients in the
main group and comparison group had to repeat the
course of treatment after 6 months. The third (control
group) - 34 people (21 men and 13 women) - includes
individuals
without
somatic
pathology.
The
examination data and the course of treatment were
entered into the personal notebook of the developed
patient. The effectiveness of the treatment was
assessed by clinical results, biochemical and
microbiological indicators after 14 days and 30 days.
Long-term results-after 12 months of observation.
Ozone has a number of advantages over other
substances as a disinfectant:
* Ozone is an extremely powerful disinfectant, able to
resist 99.9% of pathogenic microorganisms
• Rapid reaction to other antiseptic substances enters
• Ozone molecules have the property of acting up to
nano - structures due to their size being 150% smaller
than the molecules contained in other liquid antiseptics
The topical application of a generirating ozonochlorode
solution in the Prozone apparatus with high clinical
efficacy significantly reduced the demand for the use of
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American Journal Of Social Sciences And Humanity Research (ISSN: 2771-2141)
a number of drugs with side effects, making it possible
to completely end subsequent relapses.
Clinical experience accumulated in recent years shows
that pathology of the organs and tissues of the oral
cavity can only be stopped with the help of treatment
measures, but cannot be completely cured. In this
regard, it is necessary to develop and widely introduce
measures for the Prevention of major dental diseases
into practice, to understand the laws of functioning of
a healthy organism.
Diseases of the oral mucosa, which often persist with
chronic and periodic remissions and lambs, occur
against the background of an increased secondary
immunodeficiency state of the div. One of the
modern and scientifically proven theories is the
immunological concept of pathogenesis of this
pathology.
For this reason, the priority of SQAS treatment is
immunomodulation
therapy.
One
method
of
immunomodulation is to strengthen the immune
system with lipopolysaccharides of bacterial origin.
Drugs that store bacterial lysates include imunal.
Imunal is an immunocorrector of biological origin
(made from a dwarf exinacea plant), whose
immunocorrectional effect is manifested in increasing
phagocytic activity, increasing and increasing the
amount of secretory immunoglobulins belonging to
Class A, increasing and increasing the number of
immunocompetent cells responsible for the production
of antibodies, slowing the oxidative metabolism of
polymorphyadroly
leukocytes
(Figure
2).
The
composition of the drug includes 13 strains of the
following bacteria: Str. pyogenes groupe A, Str. sanguis,
St. Louis aureus, K. pneumoniae, S. pseu.
dodiphteriticum, F. nucleatum subs, nucleatum, C.
albicans, Lactobacllus acidophilus, L. helveticus, L.
lactis, L. includes a mixture of fermentatum lysates. The
composition - due to the multivalent antigen complex-
the drug is practically a locally used dry vaccine that
allows you to carry out infectious and anti-
inflammatory Immunotherapy of diseases of the oral
cavity. Imunal is used as a prophylactic agent in
complex therapy both in the acute period and in the
stage of chronic periodontitis, red flat lishay, herpes
lesions, remission of oral dysbacteriosis. The results of
the clinical effect obtained from the use of the drug
revealed a decrease in pain, swelling, bleeding of
pathological areas, significant shrinkage of the peptic
ulcer areas and an acceleration of epithelization
processes.
Figure 2. Immunal preparation made from the Scarlet exinacea plant
Immunal is an immune-stimulating drug made from
medicinal plant raw materials. The causative agent of
Immunal drops is the flowering Crimson exinacea
(Echinasea purpurea (L.) Moench) is the juice of a
freshly harvested herb of the plant.
The active substances of scarlet exinacea strengthen
the div's natural protective forces and act as a
nospecific stimulant of immunity. By increasing the
number of leukocytes (granulocytes and macrophages)
and activating phagocytosis, they contribute to the
destruction of disease-calling microorganisms in the
human div.
Research results: the results of the clinical examination
are confirmed by biochemical studies. Analysis of the
change in indicators 14 days after the use of the
treatment-prophylactic complex in the main group
indicates a decrease in elastase activity by 1.81 times (p
<0.05) and MDA concentration by 1.56 times. Ozonized
water with anti-inflammatory action and "imunal"
prevent the accumulation of lipid peroxidation
products in the oral cavity.
A significant increase in MDA concentration as an
indicator of Lipid peroxidation processes was
completely lost in the main group 30 days after the
complex of treatment measures. There was a
significant decrease in the level of signs of
inflammation: the content of the proteolytic enzyme
elastase decreased by 2.53 times (p<0.02) and MDA
decreased by 2.15 times (p<0.05), respectively, almost
reached the norm.
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American Journal Of Social Sciences And Humanity Research (ISSN: 2771-2141)
Long-term results after 1 year of observation in the
main group show that elastase activity decreased 2.0
times (p <0.02), MDA level decreased 1.87 times (p
<0.05), which corresponds to normal values.
After 14 days, a decrease in elastase activity and MDA
concentration in the comparison group was recorded
1.17 times, which remained at a very high level. A
significant decrease in the level of signs of
inflammation was observed after 30 days - elastase
1.94 times and MDA 2.0 times (p <0.05).
In the comparison group, the results of studies after 1
year showed the short-term effect of treatment using
the standard method. The Paul indicator did not reach
the norm: the MDA level practically did not change - a
decrease of 1.12 times and remained significantly
higher than the indicators of the main group, the
activity of elastase decreased slightly - 1.21 times.
The state of the div's peroxidation processes and
antioxidant systems has been more accurately
observed with API dynamics before and after
treatment. In the main group of observations, 30 days
after treatment, the activity of the antioxidant catalase
enzyme increased significantly by 3.0 times (p <0.01)
and approached normal values as close as possible.
Treatment of patients in the comparison group did not
have a significant effect on this enzyme, which
increased by 1.67 times (p <0.02). The API index,
calculated based on MDA and catalase detection,
showed a significant growth trend in core group
patients - 6.96 times (p <0.001), with slightly increased
API index in comparison group patients - by. 2.18 times
(p <0.001).
1 year after treatment, positive trends were noted in
the biochemical study of UN-stimulated oral fluid in
patients in the main group. The use of" ozonized water
" (rinsing and oral administration) has enabled catalase
activity to increase to 2.75 times (p<0.01) and API index
to 6.21 times (p<0.001), corresponding to the values of
healthy individuals.
The pronounced antioxidant properties of food
concentrate
help
normalize
the
antioxidant-
prooxidizing system and indicate its long-term effect.
The long-term results obtained prove the ability of"
ozonized water " to prevent pathological processes
caused by excessive lipid peroxide levels in the oral
cavity for a long time. After 1 year of follow-up, the rate
of dysbiosis in the main group of patients decreased by
3.06 times (p <0.01), indicating the beneficial effects of
therapeutic and prophylactic agents on oral
microbiocenosis. In patients in the comparison group,
dd decreased by 1.28 times compared to the initial
condition, as evidenced by a decrease in the protective
function of the oral cavity, a state of local immunity of
the oral cavity and a deterioration in the level of
protective forces. contributes to the development of
antimicrobial enzyme systems, increased UPM growth
in the oral cavity and increased microbial growth, and
complicates the clinical condition of chronic stomatitis.
Recommended "ozonized water" for rinsing and
impedes the process of imunal microbial colonization.
It can be used to prevent colonization of the oral cavity
with candidiasis, as well as to treat the oral cavity to
prevent
the
appearance
of
bacterial-fungal
complications in the oral cavity.
The results of studies have shown that the use of our
recommended complex for the treatment and
Prevention of candidiasis lesions of the oral cavity
suppresses the growth of fungi. Сandida prevents
recurrence of chronic forms of candidiasis and
exacerbation of this disease.
CONCLUSION
In patients with chronic recurrent aphthous stomatitis
of the oral mucosa against the background of chronic
gastroduodenitis, clinical studies have shown: the
following decrease in indicators was 1.24 times,
deterioration of hygienic condition was 1.92 times,
Schiller-Pisarev fracture increased by 2.06 times,
stimulated salivation by 1.84 times and non -
stimulated salivary detachment-by 2.09 times, acid
shift of pH. During biochemical testing of stimulated
oral fluid in patients with chronic gastroduodenitis, a
significant increase in the activity of inflammatory signs
was observed: elastase 3.45 times and MDA 1.87 times;
reduction of the antioxidant catalase enzyme by 3.5
times; decrease in API index reflects significant changes
in antioxidant-prooxidant balance by 6.25 times. The
use of the set of therapeutic measures proposed by US
normalizes the activity of MDA, elastase and catalase,
restores antioxidant protection, contributes to a
significant decrease in urease levels and a significant
increase in lysozyme secretion, normalizes oral
microbiocenosis.
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