Авторы

  • Davron Khojimetov
    Andijan State Medical Institute
  • Farrux Akbarov
    Andijan State Medical Institute

DOI:

https://doi.org/10.71337/inlibrary.uz.arims.75923

Аннотация

Acute pancreatitis (AP) is a serious pathology of the abdominal organs, which to this day is one of the most important problems of emergency abdominal surgery. Indeed, the incidence and consistently high mortality rates are confirmed by the indicators. The etiological factors of pancreatitis are mainly gallstone disease, alimentary tract, and alcoholism. Acute pancreatitis of biliary etiology occurs in about 30-50% of cases in European and North American countries, while the overall mortality rate is about 10% and has almost no tendency to decrease. With destructive pancreatitis, pancreatic necrosis, it reaches 75%.


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ACADEMIC RESEARCH IN MODERN SCIENCE

International scientific-online conference

102

OPTIMIZATION OF ENDOSCOPIC TREATMENT METHODS IN

PATIENTS WITH ACUTE PANCREATITIS.

Khojimetov Davron Shukhratbekovich

Akbarov Farrux Saydaliyevich

Andijan State Medical Institute

https://doi.org/10.5281/zenodo.15104757

Relevance:

Acute pancreatitis (AP) is a serious pathology of the abdominal

organs, which to this day is one of the most important problems of emergency
abdominal surgery. Indeed, the incidence and consistently high mortality rates
are confirmed by the indicators. The etiological factors of pancreatitis are mainly
gallstone disease, alimentary tract, and alcoholism. Acute pancreatitis of biliary
etiology occurs in about 30-50% of cases in European and North American
countries, while the overall mortality rate is about 10% and has almost no
tendency to decrease. With destructive pancreatitis, pancreatic necrosis, it
reaches 75%.

Objective:

To optimize the use of retrograde endoscopic techniques to

reduce complications, mortality, and improve outcomes in patients with acute
pancreatitis.

Material and methods.

All patients with acute pancreatitis treated in the

surgical department of the 3rd clinic of the ADTI and the surgical departments of
the ASMSH from 2020 to 2024 participated in the study. All patients were
admitted to the emergency department as an emergency or transferred from
specialized departments with clinical manifestations of acute pancreatitis. The
majority of the study included patients aged 21 to 65 years. 100 men (43
percent), 100 women (57 percent). The average age of the patients was 44 +- 2.0
years. The patients were mainly divided into 2 groups. 36 patients in group 1
were treated retrospectively with standard conservative drugs. Group 2
included 32 patients who underwent endoscopic papillosphincterotomy and
stenting of the Wirsung tract in combination with the Santdart conservative
method.

Results and discussion.

The results of treatment of patients with pancreatitis and pancreatic

necrosis complicated by endoscopic methods of pancreatic duct decompression
depend on the nature of pancreatic necrosis and the time of onset of the disease.
In group I, patients were hospitalized in the late stages with various
complications after laparotomy, external drainage of the common bile duct, and
28% (10) of patients died, while in group II, patients underwent laparotomy,
endoscopic papillosphincterotomy and stenting of the Wirsung tract with the


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Santdart conservative method. Thus, based on the obtained data, in order to
accurately diagnose pancreatic necrosis, we recommend that abdominal
ultrasound and CT be performed in the first hours (initial 2-6 hours) of the
patient's hospitalization.

Conclusion:

Thus, endoscopic operations in patients with pancreatic

necrosis are performed as part of a complex of therapeutic interventions in
patients with pancreatic necrosis. They are performed early in the course of
pancreatic necrosis. The volume of endoscopic interventions depends on the
etiology of the disease, the state of the bile ducts and the pancreatic ducts
(Wirsung). In addition, the availability of trained doctors and specialized
hospital departments with experience in the treatment of patients with
pancreatic necrosis and endoscopic interventions in the bile ducts and
pancreatic ducts is of great importance in reducing the number of complications
of pancreatic necrosis and death, and endoscopic operations should be
performed by a qualified endoscopist.

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Munigala S, Yadav D. Case-fatality from acute pancreatitis is decreasing but

its population mortality shows little change. Pancreatology. 2016; 16(4): 542-
550.
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Kurti F, Shpata V, Kuqo A, Duni A, Roshi E, Basho J. Incidence of acute

pancreatitis in Albanian population. Mater Sociomed. 2015; 27(6): 376-369.
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Karakayali FY. Surgical and interventional management of complications

caused by acute pancreatitis. World J Gastroenterol. 2014; 20(37): 13412-
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Styazhkina SN, Sitnikov VA, Ledneva AV. Acute destructive pancreatitis in

urgent surgery. Bulletin of Saint Petersburg University. 2010; 354-355. Russian
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Huang Q., Shao F., Wang C. et al. Nasobiliary drainage can reduce the

incidence of post-ERCP pancreatitis after papillary large balloon dilation plus
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ACADEMIC RESEARCH IN MODERN SCIENCE

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cost-effectiveness analysis // Rev. Esp. Enferm. Dig. - 2017. - Vol. 109, № 3. - P.
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pancreatitis: an overview. World J Gastroenterol. 2014; 20(43): 16106-16112.
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Библиографические ссылки

Munigala S, Yadav D. Case-fatality from acute pancreatitis is decreasing but its population mortality shows little change. Pancreatology. 2016; 16(4): 542-550.

Kurti F, Shpata V, Kuqo A, Duni A, Roshi E, Basho J. Incidence of acute pancreatitis in Albanian population. Mater Sociomed. 2015; 27(6): 376-369.

Karakayali FY. Surgical and interventional management of complications caused by acute pancreatitis. World J Gastroenterol. 2014; 20(37): 13412-13423.

Styazhkina SN, Sitnikov VA, Ledneva AV. Acute destructive pancreatitis in urgent surgery. Bulletin of Saint Petersburg University. 2010; 354-355. Russian (Стяжкина С.Н., Ситников В.А., Леднева А.В., Варганов М.В.

He Q. B., Xu T., Wang J. et al. Factors for post-ERCP pancreatitis and hyperamylasemia: A retrospective single-center study // J. Dig. Dis. - 2015. - Vol. 16, № 8. - P. 471-478. https://doi.org/10.1111/1751-2980.12258.

Huang Q., Shao F., Wang C. et al. Nasobiliary drainage can reduce the incidence of post-ERCP pancreatitis after papillary large balloon dilation plus endoscopic biliary sphincterotomy: a randomized controlled trial // Scand. J. Gastroenterol. - 2018. - Vol. 53, № 1. - P. 114-119. https://doi.org/10.1080/00365521.2017.1391329.

Hwang H. J., Guidi M. A., Curvale C. et al. Post-ERCP pancreatitis: early precut or pancreatic duct stent? A multicenter, randomized-controlled trial and cost-effectiveness analysis // Rev. Esp. Enferm. Dig. - 2017. - Vol. 109, № 3. - P. 174-179. https://doi.org/10.17235/reed.2017.4565/2016.

Keulemans Y. C. A., de Wijkerslooth T. R., van de Vrie W. et al. Dutch Pancreatitis Study Group. Aggressive fluid hydration plus non-steroidal anti-inflammatory drugs versus non-steroidal anti-inflammatory drugs alone for post-endoscopic retrograde cholangiopancreatography pancreatitis (FLUYT): a multicentre, open-label, randomised, controlled trial // Lancet Gastroenterol. Hepatol. - 2021. - Vol. 6, № 5. - P. 350-358. https://doi.org/10.1016/S2468-1253(21)00057-1.

Ostrovskiy VK, Makarov SV, Smol’kina AV, Alimova RI, Nurtdinova GI, Frolov AI, et al. Pancreatic necrosis is the main cause of mortality from peritonitis outside the hospital. Modern Problems of Science and Education. 2015; 1-1: 1313.

Kokosis G, Perez A, Pappas TN. Surgical management of necrotizing pancreatitis: an overview. World J Gastroenterol. 2014; 20(43): 16106-16112.

Borodin NA, Maltceva OV, Gibert BK, Zaitcev EJ. Modern approaches to treatment of destructive forms of pancreatitis, ways to reduce mortality. Medical Science and Education of the Ural. 2015; 16: 2-1(82): 70-73.