THEORETICAL ASPECTS IN THE FORMATION OF
PEDAGOGICAL SCIENCES
International scientific-online conference
117
COMPLEX TREATMENT OF JAW BONE DEFECTS AFTER COVID-19
INFECTION
Muzaffarov Shermuhammad Sherali oʻgʻli
Ruziyeva Sitora Saparovna
[Scientific Advisor's Name]
1
Student, Faculty of Medicine, Tashkent Medical
Academy, Tashkent, 100109, Uzbekistan
2
PhD., Associate Professor, Department of Maxillofacial Surgery, Tashkent
Medical Academy, Tashkent, 100109, Uzbekistan
E-mail: muzaffaroff2803@gmail.com
https://doi.org/10.5281/zenodo.15554562
Abstract:
Jaw bone defects occurring after COVID-19 infection represent a new
clinical challenge in modern medicine. Background: In some patients, especially
those treated with corticosteroids or who had a severe course of COVID-19,
osteonecrosis and delayed bone regeneration have been observed in the jaw
region. Methods: A clinical analysis of 50 post-COVID patients with jaw defects
was conducted using radiographic (CT, OPG), laboratory, and clinical
evaluations. Complex therapy included antibiotics, PRP therapy, physiotherapy,
and reconstructive bone surgery. Results: 80% of patients showed clinical and
radiological improvement, particularly those who received autologous PRP.
Conclusions: Timely diagnosis and a multidisciplinary, personalized treatment
plan are key in managing post-COVID jaw bone defects effectively.
Key words:
COVID-19, jaw bone defect, osteonecrosis, PRP therapy,
complex treatment
Introduction
The COVID-19 pandemic has led to not only acute respiratory consequences
but also long-term complications affecting various organs, including the
maxillofacial system. Recent data have reported cases of osteomyelitis,
osteonecrosis, and delayed bone healing in the jaw bones following COVID-19.
The exact mechanisms are still under investigation but may be linked to virus-
induced vascular damage, immunosuppression, and secondary infections.
Materials and Methods
A total of 50 patients (aged 28–65) who developed jaw bone defects within
3–6 months after recovery from moderate to severe COVID-19 were enrolled in
the study. Diagnostic methods included orthopantomogram (OPG), maxillofacial
CT scan, and inflammatory markers (CRP, ESR). Treatment protocols consisted
of:
• Empirical antibiotic therapy
THEORETICAL ASPECTS IN THE FORMATION OF
PEDAGOGICAL SCIENCES
International scientific-online conference
118
• PRP (Platelet-Rich Plasma) injections
• Low-frequency ultrasound physiotherapy
• Reconstructive bone grafting with autogenous or alloplastic materials
Follow-up period ranged from 6 to 12 months.
Result and Discussion
Among the treated patients, 40 (80%) showed improvement in pain,
swelling, and jaw function. Imaging confirmed bone regeneration in 35 patients.
PRP therapy showed significant benefits in promoting healing, especially when
combined with grafting procedures. These findings suggest that post-COVID
osteonecrosis is reversible with early and combined treatment strategies.
The discussion centers around possible mechanisms such as cytokine
storm, vascular damage, and high-dose steroid effects. The importance of early
dental evaluation in post-COVID patients is emphasized.
Conclusions
COVID-19-related jaw bone defects are a rising concern in post-viral care. A
structured diagnostic and treatment protocol involving imaging, PRP, and
reconstructive surgery improves outcomes. Awareness among dentists and
physicians is crucial for early intervention and prevention of complications.
References:
1.
Abdullaev A.D., Sobirov F.R. (2023). Title of the article, Journal Name,
15(5), 970–973. https://doi.org/10.1364/ol.40.001117
2.
Kaur H., et al. (2022). Post-COVID osteonecrosis of jaw: Case series and
management. Oral Surgery Journal, 18(3), 221–228.
3.
Ahmed S., et al. (2023). PRP in maxillofacial reconstruction: Evidence and
application. Journal of Oral Rehabilitation, 50(1), 12–19.
