Dermatology

Currently, the Uzbek market is dominated by imported medical and cosmetic products, which outweigh domestic medicines.

Study of the psychological characteristics of patients with psoriasis for the purpose of correction is set to conduct an adequate effective therapy. The aim of the study was to determine the level of situational and personal anxiety of patients and to identify high-level structure of anxiety. We examined patients using integrative anxiety test (1AT). Correction emotional background of patients will improve the results of treatment and improve the quality of life for people with this disorder.

To solve the problems in the surveyed 45 patients: examination, laboratory complex, immune and in-strumental methods. All 45 patients with SLE kidney disease manifested itself in the form of lupus nephritis. Syndrome hypertension vstre-chalsya in 35.5% of cases, the syndrome of chronic renal failure in 37.7% of cases. Urinary syndrome characterized by moderate proteinuria (75.5%), hematuria (73.3%) and leukocyturia (73.3%). Positive correlation of tumor necrosis factor α, C-reactive protein level of creatinine, urea, ESR and SLE activity, which confirms the participation of the factors described in the immune process lupus inflam-mation.

This article analyzes the global distribution characteristics of hymenolepiasis and the epidemiological situation in the territories of Uzbekistan and the Republic of Karakalpakstan. The etiology of the disease, transmission routes, and spread factors are examined. Epidemiological observations conducted in Karakalpakstan reveal a higher prevalence of the disease among children compared to other groups. Based on the research results, the high incidence of hymenolepiasis is attributed to the population living in unfavorable sanitary and hygienic conditions, failing to seek timely medical care, and consequently, the inability to diagnose the disease in a timely manner. The article has practical significance in developing preventive measures against this parasitic infection.

Systemic lupus erythematosus (SLE) is a systemic autoimmune disease of unknown etiology, characterized by hyperproduction of non-organ-specific autoantibodies to various components of cell poison with the development of immune-inflammatory damage to tissues and internal organs [1].

On the basis of the Resolutions of the President of the Republic of Uzbekistan No. PQ 5369 of March 24, 2018, No. PQ 3630 of March 29. 2018, No. PQ 4202 of February 20. 2018, rural settlements are developing not only economically but also socially. At the same time, new important and urgent problems have arisen in the science of hygiene and sanitary practice. Addressing these issues is directly related to improving working and living conditions in rural areas.

The given article describes the significant decrease of SD 3 - lymphocytes (T-cells), CD-4 lymphocytes (T-
helper cells), the absorptive function of neutrophils and average importance of IgM in patients with chronic eczema.
The Factors of SD-22 (B-cells) and CIC (circulating immune complexes) as well as the average importances of IgA and
IgG of all patients were higher than reliable factors. Using Immunomaks in complex with traditional terapy prevents the development relapse disease (12.5% against 75,0 % in group of the comparison (R<0.01) and greatly shortens the peri-od of the treatment

Itlardagi mavjud patologiyalar orasida ichki yuqumsiz kasalliklaridan keyin yetakchi o'rinlardan birini jarrohlik kasalliklar egallaydi. Teri yalligTanishlarini optimal davolash yoTlarini topish. patogenetik asoslangan davolashni belgilash. toksik - allergik holatlami rivojlanishiga olib keladigan medikametozli terapiya xajmini qisqartirish veterinariyaning aktual muammosi bo Tib qolmoqda. Sintetik preparatlar ko'proq toksik bo Tib. qiyin boshqariladigan autoimmun patologiyalar rivojlanishiga olib kelishi munikm. Allergik holatlami rivojlanishiga olib keladigan medikametozli terapiya xajmini qisqartirish veterinariyaning asosiy muammosi bo‘lib qolmoqda. Bunday vazifalami tibbiyot va veterinariyada qadimdan qo'llanib kelgan dorivor o'simliklar bajarib kelgan.

The article presents the current trends in biotechnology and the prospects for cell therapy. The main methods for obtaining dermal equivalents to optimize the regeneration of superficial and deep skin and soft tissue defects are presented. When analyzing the available literature data, it was determined that today there is no “perfect” dermal equivalent. However, huge commercial interest in bioengineering designs and large investments in such projects will help to obtain optimal skin equivalents in the near future.

The work was carried out examination and treatment of 30 patients with systemic lupus erythematosus (SLE). All patients underwent synchronous intensive therapy (SIT), which included a three-fold plasmapheresis (PF) with removal of 40-60 ml of plasma per kg of patient weight at intervals of 4-5 days. After each PF intra-venously over 45 minutes was administered 1.0 MP, and after the second - more added 1.0 cyclophosphamide. The dose of oral prednisolone should not exceed 40 mg / day. In the second phase was introduced on a monthly basis only 1.0 cyclophosphamide. Significantly decreased the frequency of erythema in the form of "butterfly", stomatitis, cheilitis enantemy and lupus, edema syndrome. Completely regressed pulmonary process, fever, lymphadenopathy, stabilized body weight, less defined polyserositis, arthritis

In the context of globalisation and the tightening of technical regulations of the Eurasian Economic Union TR 009/2011, it is important to analyse the market structure, consumer
preferences and the potential for localising the production of cosmetic products.

510 patients aged 60-92 with deep bums had been under the observation of the authors 100 burnt patients were admitted
in a shock state. They demonstrated stable hypotony. elevated CIT (Central Intraocular tension) the change in ECG and less
marked hemoconcertration.
I.T.T. in the first 24 hours resulted in hemodynamic stabilization on the background of cardiac glucosides
administration. The authors succeeded in taking 69% of burnt patients out of shock state. I.T.T. in the period of acute bum toxaemia (in 169) and septicotoxaemia (in 184) was directed to the struggle against intoxication, anaemia, hypo and dysproteinaemia. To tear away necrotic tissues proteolytic ferments were used, 10% solution of urea, laserotherapy, propolis ointment and metallocomplexes. 409 patients were operated. Out of 72 persons died (17,6%)

The article analyzes the results of the prevention and treatment of multiple organ failure in severely
burned. The object of the study were 330 victims with deep burns, aged 18 to 74 years. 320 (96.97%) patients
had IIIB-IV deep burns over 10% of the body surface. Studies have shown that complex against shock infusion-
transfusion therapy with inotropic and organ-protective support, depending on impaired function of vital or-
gans and early active surgical tactics facilitates the course of burn disease, reduces the number of multiple or-
gan failure and mortality in severely burned

The study included 177 patients aged 14 to 65 years who entered the state of burn shock of varying de-grees. The frequency of the development of digestive and absorption disorders depends on the severity of the thermal injury. Treatment of patients with the syndrome of intestinal insufficiency helps to reduce complica-tions and mortality in patients with heavy burns

Multiple organ failure complicates the course of the burn disease and increases the likelihood of death in patients with severe thermal trauma. The analysis of 210 victims (mean age 25.5±5.4 years) with deep burns of more than 25% of the body surface and a burn shock of I-II-III degree (deep burn area of 20-40% bw) from 2010 to 2017 years. The structure of polyorganic insufficiency, frequency (cardiovascular, respiratory, renal, hepatic insufficiency, dysfunction of the central nervous system, gastrointestinal tract) and methods of its cor-rection are studied.

The incidence of cutaneous leishmaniasis in the Republic of Uzbekistan in recent years has not tended to decline, and the use of drugs recommended by WHO remains unavailable in the pharmacy network for the public, which leads to the search and use of new alternative therapies. The article presents a new complex method for the treatment of cutaneous leishmaniasis, developed at the Scientific Research Institute of Medical Parasitology named after L.M. Isayev.

Application of the new complex method of treatment for all types of cutaneous leishmaniasis contributed to the
rapid relief of inflammation in the outbreak and scar formation in a shorter time.

The study showed that from the moment when the graft remains alive epithelial cells, lymphoid infiltration is stopped and at the same time there is a reaction to a foreign body - a particle of matter horny skin. Polyblasts and multi-nucleated macrophages can be either local origin, or formed of lymphocytes involved in graft infiltration.

Ultrathin slices from the human abdominal skin and platinum – carbonic replicas, obtained by means of the freeze – fracture method have been studied electron microscopically. Transmembranous proteins are revealed on the membrane surface as membranebinded particles with the diameter 5 – 7 mm.

Thermal burn is a severe form of injury, causing structural and functional disorders in numerous body systems. Because of the complexity of the process and the involvement of several body systems, it is impossible
to analyze this state by in vitro experiments. Over the past two decades, a number of experimental burn models
have been developed. The review examines the healing of wounds in animals with burn injury, the advantages
and disadvantages of these models for rational use. The paper considers three main types of animals used for
modeling burn wounds.

The aim of present work was work out prognosis iridodiagnosticand dermatogliphic markers for sui-cidents. At process of study the dermatogliphic indices and iridodiagnosi speculiarities were revealed at per-sons’ cadavers, being killed themselves with suicide, the informativity of iridodiagnostic and dermatogliphicin-dices, were specified. For the first time the interconnection of dermatologic and iridodiagnostic indices in sui-cidents were researched.

According to the World Health Organization, there are about 12 million leishmaniasis patients, about 2 million people get this disease every year. An analysis of the situation on skin leishmaniasis, as well as an assessment of the possible impact of climate change on vector carriers, is carried out by mathematical modeling using climate predictors. Modeling the spread of cutaneous leishmaniasis allows to obtain a number of data for possible approximation of the disease in the future.

Burns are one of the most common types of injuries that can occur at home or at work, and are not only a medical but also a socio-economic problem.

Anamnestic analysis of the causes of keloid scars in the region showed that the main cause of keloids is a post-acne keloid scars that occur in adulthood

Conducted comprehensive studies in endemic areas with the analysis of the spatial distribution of cases in relation to environmental factors and taking into account other risk factors such as socio-economic status of the community, the activities of carriers and / or CL tanks is essential to identify areas of high risk. In recent years, the widespread use of geographic information systems (GIS) for the analysis of risk factors associated with disease vectors usually used in the study of leishmaniasis in different countries. Definition of high-risk ar-eas of the disease is crucial to mobilize resources for health in order to reduce the disease. Analysis of the re-
sults of predictive risk maps distributed in geographic space of great importance in the management of the control of leishmaniasis