T A D Q I Q O T L A R
jahon ilmiy – metodik jurnali
https://scientific-jl.com
63-son_1-to’plam_Iyun-2025
385
ISSN:3030-3613
COMPARATIVE CHARACTERISTICS OF MORPHOLOGICAL INDICES
OF THE STOMACH IN EXPERIMENTAL LIVER DAMAGE
Sanoyev Farhod Fayzulloyevich
Department of Clinical Sciences, Zarmed University
Annotation:
Numerous fundamental studies devoted to the problem of the
complex influence of exogenous and endogenous effects on the human div have
proven their depressive effect on the div's regulatory systems. At the same time, the
study of morphological indices of gastric tissue, sensitive to homeostasis disturbances
in experimental conditions with liver damage, remains relevant for researchers.
Key words:
liver damage, hepatotoxicity, stomach, morphology
Relevance
. Drug-induced liver injury is a heterogeneous group of clinical
and morphological variants of liver damage caused by the use of drugs. The
terms "drug-induced hepatotoxicity" and "hepatotoxic reactions" are synonyms
for DLI. Drug-induced liver injury (DILI) accounts for about 10% of adverse
drug reactions, causing 2-5% of all cases of jaundice and up to 25% of cases of
fulminant liver necrosis. The incidence of DLI depends on gender, age, genetic
predisposition, activity of metabolic processes in the div, the use of other drugs
or alcohol, and concomitant liver diseases. In the presence of a high connection
of the drug with plasma proteins, a deficiency of proteins in food and
hypoalbuminemia contribute to an increase in the toxic effect [Yu.R. Zyuzya,
2025]. Drug-induced liver damage can vary in severity, manifesting as acute
hepatitis (up to acute massive liver necrosis) and hepatosis, and the same
substance can cause both hepatitis and hepatosis in different patients. The
outcomes of these conditions are chronic hepatitis, liver cirrhosis, and
hepatobiliary malignancies. Drug-induced hepatitis carries the risk of fulminant
liver failure, and with the development of hepatic coma, mortality reaches 70%
or more [Ivanova, 2025].
Almost half of the world's population suffers from gastrointestinal
diseases. Statistics show that the prevalence of gastritis among gastrointestinal
diseases is more than 80%. Today, this serious disease is often observed not only
in adults, but also in school-age children and students. The most common cause
of gastritis is poor nutrition: hasty and unsystematic eating, unchewed or dry
food; too hot or too cold food; consumption of spicy food (mainly spicy and very
salty). Most often, diseases develop in people who are in a state of nervous and
mental stress, neglect healthy eating, abuse alcohol and smoking [Abatov A.E.,
T A D Q I Q O T L A R
jahon ilmiy – metodik jurnali
https://scientific-jl.com
63-son_1-to’plam_Iyun-2025
386
ISSN:3030-3613
2020].
Functional dyspepsia (FD) is the most common nosology in the group o f
functional diseases of the gastrointestinal tract [Knill-Jones R.P., 2021].
According to population studies, from 10 to 30% of the general population
complain of dyspeptic disorders [McQuaid K. et al., 2018; Talley N.J. et al.,
2020; Tack J. et al., 2016; Piessevaux H. et al., 2019; Houghton L.A. et al.,
2016], but only about a quarter of them seek medical help. Thus, among all cases
of visits to general practitioners, the proportion of patients with dyspeptic
syndrome is 2-5% of patients [Holtmann G., Talley N.J., 2020; Peura D., 2015].
Dyspeptic symptoms account for 20-40% of gastroenterological complaints
[Bova A.A., Kriushev P.V., 2019], according to the literature, organic causes are
identified in 40% of patients, while in the rest dyspepsia is functi onal [Hotz J.
Reizmagen, 2022; Shaib Y., El-Serag, 2014; Mahadeva S., 2016; Palsson O.S.,
2014]. Approximately 50% of patients with FD experience a decrease in working
capacity and daily activities [Van Oudenhove L. et al., 2018]. Consequently, FD
significantly affects the physical, social, emotional and psychological
functioning of the patient, which leads to a decrease in the quality of life
[Wiklund I. et al., 2018; Staque M.J., 2017; Allescher H.D., 2020; Mones J. et
al., 2022]. Numerous fundamental studies devoted to the problem of the complex
influence of exogenous and endogenous influences on the human div have
proven their depressive effect on the regulatory systems of the div. At the same
time, the study of morphological parameters of gastric tiss ue, sensitive to
homeostasis disturbances in case of liver damage under experimental conditions,
remains relevant for researchers.
Literature
1.
Balukova E. V., Uspensky Yu. P., Fominykh Yu. A. Liver lesions of various
origins (toxic, drug-induced, dysmetabolic): from etiological heterogeneity to
a single unified therapy for patients // RMJ. Medical Review. - 2018. - Vol.
2. - No. 1-1. - P. 35-40.
2.
Zyuzya Yu. R., Toshchevikov M. V., Maltsev R. V. Acute toxic liver
dystrophy as an unpredictable dose-dependent reaction during anti-
tuberculosis therapy // Tuberculosis and socially significant diseases. - 2025.
- No. 1-2. - P. 52-57.
3.
Ivanova D. A., Tityukhina M. V. Drug-induced liver damage in the treatment
of patients with tuberculosis // Tuberculosis and socially significant diseases.
- 2025. - No. 1-2. - P. 32-43.
