Mualliflar

  • Patel Bhakti
    Andijon davlat universiteti
  • Priyadarshi Gautam
    Andijon davlat universiteti
  • Kumar Dipak
    Andijon davlat universiteti
  • Patel Ashish
    Andijon davlat universiteti

DOI:

https://doi.org/10.71337/inlibrary.uz.universaljurnal.110712

Kalit so‘zlar:

Amfoterisin B tsellyuloza nanofiber Vitamin B12 Leishmania donovani sitotoksiklik MTT tahlili

Annotasiya

Leyshmanioz butun dunyo bo'ylab e'tibordan chetda qoladigan yuqumli kasallik bo'lib, protozoa parazitlari sabab bo'ladi. Leyshmaniozni davolash cheklangan va ko'pincha jiddiy yon ta'sirlar bilan bog'liq. Amfoterisin B - leyshmaniga qarshi yuqori samarali dori; ammo, uni og'iz orqali qabul qilish past bioavailability va toksikligi bilan cheklangan. Ushbu muammoni hal qilish uchun AmB ni og'iz orqali yuborish uchun VitB12-PEG4000-AmB-CNFs yangi formulasi ishlab chiqilgan. Formulyatsiya 28,53 sirt zaryadiga ega bo'lgan 490 nm zarracha hajmini ko'rsatdi va CNFlarning BET sirt maydoni 42,08 m2 / g dori yuklash imkoniyatini osonlashtirdi. FTIR va XRD funktsiyani, preparatni yuklashni va konjugatlarning inkapsulyatsiyasini tasdiqladi. Formulyatsiya SEM tasvirlarida yuzaki tartibsiz va AmB-CNFlarda VitB12-PEG4000 konjugatlarining ko'p qatlamli funksionallashuvi bilan kuzatildi, bu EDS spektrlari N ning og'irligining% o'sishini ko'rsatganligini tasdiqlaydi. amastigotlar mezbon hujayralarga sitotoksiklikni kamaytiradi. Ushbu innovatsion yondashuv leyshmaniozni davolashdagi doimiy muammolarni samarali hal qilish uchun maqsadli etkazib berishni kam yon ta'sirlar bilan birlashtirgan istiqbolli terapevtik alternativani taqdim etadi.


background image

“ZAMONAVIY BIOLOGIYANING DOLZARB MUAMMOLARI VA

RIVOJLANISH ISTIQBOLLARI”

xalqaro ilmiy-amaliy anjuman materiallari

adu.uz

universaljurnal.uz

11

BRIDGING NANOSCIENCE AND PARASITOLOGY: AMINE-FUNCTIONALIZED

CELLULOSE NANOFIBERS WITH AMPHOTERICIN B AND VITAMIN B12 FOR

PRECISION DRUG DELIVERY IN LEISHMANIASIS TREATMENT

Bhakti Patel

1

, Gautam Priyadarshi

1

, Dipak Kumar Sahoo

2

, and Ashish Patel

1

*

1

Department of Life Sciences, Hemchandracharya North Gujarat University, Patan-384265,

Gujarat, India; bhaktipatel2233@gmail.com (B.P.); priyadarshigautam411@gmail.com (G.P.)

2

Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State

University, Ames, Iowa, USA;

*Corresponding author: Ashish Patel (uni.ashish@gmail.com (A.P.))

KEYWORDS: Amphotericin B, cellulose nanofiber, Vitamin B12, Leishmania

donovani, cytotoxicity, MTT assay

ABSTRACT

Leishmaniasis is a globally neglected infectious disease that is caused by protozoan parasites.

The treatment of leishmaniasis is constrained and frequently associated with serious side effects.
Amphotericin B is a highly effective anti-leishmanial drug; however, its oral administration is
restricted by its low bioavailability and toxicity. To address this problem, a novel formulation,
VitB12-PEG4000-AmB-CNFs, was developed for oral delivery of AmB. The formulation showed a
particle size of 490 nm with a surface charge of 28.53, and the BET surface area of the CNFs was
42.08 m2/g facilitated drug loading capacity. FTIR and XRD confirmed the functionalization, loading
of the drug, and encapsulation of the conjugates. The formulation was observed in SEM images with
irregular surface and multi-layered functionalization of VitB12-PEG4000 conjugates on AmB-CNFs,
supporting that EDS spectra showed an increase in the% weight of N. VitB12-PEG4000-AmB-CNFs
showed strong anti-leishmanial activity against Leishmania donovani intramacrophage amastigotes
while minimizing cytotoxicity to host cells. This innovative approach presents a promising
therapeutic alternative, combining targeted delivery with reduced side effects to effectively address
the persistent challenges in treating leishmaniasis.