Vol. 4 No. 04 (2024): Volume 04 Issue 04

Molecular allergological diagnostics is a modern method of determining sensitization, which allows to diagnose specific IgE with higher accuracy than traditional diagnostic methods, especially skin tests. This study was conducted in order to determine the types of allergenic molecules to which patients with allergic diseases are sensitive.

Recent research in this area has shown that in many tissues, including skin, stem cells become dormant as they mature, slowing down their rate of division and not responding as effectively to stimulation [1]. A decrease in the activity of stem cells leads to the fact that the rate of skin renewal slows down and defects begin to accumulate in it; the skin ages [2]. Recently, the attention of scientists has been attracted by plant stem cells, which produce a complex of molecular regulators that are universal. These regulators are capable of changing the functioning of human skin stem cells, partially returning them the energy of youth [3]. One of the most popular ingredients today is Swiss apple stem cells. Each adult apple stem cell can independently generate new cells and, in a concentration of just 0.1%, stimulate the division of human stem cells by 80% [4]. Phytostem (plant) cells were discovered relatively recently - only in the second half of the 20th century [5]. And the most effective in influencing human cells are considered to be plant stem cells, green apple phytostem cells. Scientists have proven that they are active biostimulators of human cells [6]. Plant cell preparations are absolutely hypoallergenic, unlike those obtained from animal or human tissues.

The article contains information about the development of livestock farming in our republic, the introduction of cattle breeding, increasing the production of cattle breeds, cattle products, and increasing the productivity of animals.

This article describes the diversity of insects and their world, the practical use of insects and the use of pest control methods in agriculture, the life functions of insects, their behavior, and population dynamics.

In this article, we look at the cutting-edge research and innovation that is transforming the sodium silicate pentahydrate production landscape. We will explore the basic conditions and scientific principles behind this technology, providing a comprehensive overview of the process from liquid glass processing to the production of the pentahydrate product. Additionally, we'll look at the potential economic, environmental and industrial impacts of this homegrown advance, illuminating how it could reshape the global sodium silicate market.

The efficacy of bio-drugs is a critical aspect of modern healthcare, influencing treatment decisions and patient outcomes. Assessing the effectiveness of these drugs involves complex methodologies and considerations, spanning from molecular interactions to clinical trials. This review provides an overview of the various approaches used to evaluate bio-drug efficacy, including in vitro assays, animal models, and clinical studies. Additionally, it discusses the challenges and advancements in this field, such as personalized medicine and novel biomarkers. Understanding bio-drug efficacy is essential for optimizing therapeutic interventions and improving patient care across diverse disease states.

Allergic diseases(AD) are one of the most urgent problems of modern medicine. The prevalence of bronchial asthma in children and adults in the Bukhara region was studied. The primary incidence of bronchial asthma in the age structure of the population was studied according to the coupons of an outpatient patient (form No. 025-12u) for 2015–2019 in 10 age groups (1–5 years, 5–9 years, 10–14, 19, 20–29, 30–39, 40–49, 50–59, 60 and older) in the city of Bukhara and twelve districts of the Bukhara region.The study of the distribution of indicators of the incidence of bronchial asthma in the Bukhara region revealed that the areas of risk for this pathology are areas with industrial zones: Karakul, Karulbazar and the city of Kagan. The risk groups for the incidence of bronchial asthma are children under 9 years of age and adults aged 60 years and older. The prevalence of bronchial asthma ranges from 5.5 per 1,000 population in relatively clean areas of residence to 33.5 per 1,000 population in industrialized areas.        

Thus, the study showed that the highest incidence of general morbidity with bronchial asthma in children and adults is observed in the city of Kagan with the operation of an oil extraction plant, in the Karaulbazar district with an oil refinery and in the Karakul district with a Kandim gas processing plant. An increased risk of primary incidence of bronchial asthma exists for children aged 3 to 9 years and for adults 60 years of age and older.

Schizophrenia is a complex psychiatric disorder characterized by a range of cognitive, emotional, and behavioral symptoms. Despite significant advancements in pharmacotherapy, challenges such as poor treatment adherence, limited efficacy, and adverse side effects remain prevalent. Drug delivery systems have emerged as promising approaches to overcome these challenges by improving drug targeting, bioavailability, and patient compliance. This review explores recent advancements in drug delivery systems tailored for the targeted treatment of schizophrenia. Various strategies, including nanoparticle-based formulations, lipid-based carriers, depot injections, and transdermal patches, are examined for their potential to enhance the delivery of antipsychotic medications to the brain while minimizing systemic side effects. Additionally, the review discusses the application of novel technologies, such as implantable devices and nanoscale drug carriers, in optimizing drug release kinetics and achieving sustained therapeutic effects. By highlighting recent developments and future prospects in drug delivery for schizophrenia treatment, this review aims to inform researchers, clinicians, and pharmaceutical developers about the evolving landscape of targeted therapy in mental health care.