Vol. 3 No. 05 (2023): Volume 03 Issue 05

At the present stage of development, one of the most common pathological conditions of the gastrointestinal tract (GIT) in children is chronic constipation. Chronic constipation is a serious medical and social problem in all countries of the world, due to its wide prevalence, low effectiveness of therapy, reduced social activity, impaired quality of life of patients and increased use of healthcare resources.

This study aims to determine the optimal dosage for m-Tablet, a novel pharmaceutical technology, to maximize convenience and patient compliance. Medication non-compliance is a significant issue that affects treatment outcomes. m-Tablet offers potential advantages such as personalized dosing, convenience, and patient engagement. A randomized controlled trial design was utilized, and participants were assigned to different dosage groups of m-Tablet. Data was collected through patient interviews, self-reporting, and electronic monitoring devices. The results indicated that a specific dosage strength or regimen of m-Tablet provided the highest level of convenience for patients, resulting in improved patient compliance. This study highlights the importance of convenience and patient compliance in medication adherence and suggests that m-Tablet has the potential to revolutionize medication delivery.

The article presents the results of a prospective cohort study, which included 26 pregnant women at high risk of infection, who in the postpartum period were divided into 2 groups: I – the main (n=14) and II – the comparison group (n=12). The groups were comparable in age, according to somatic and obstetric-gynecological anamnesis. The comprehensive examination included an assessment of anamnestic data and the results of clinical, microbiological, and instrumental research methods.

Limitations in trial design, accrual, and data reporting impact efficient and reliable drug evaluation in cancer clinical trials. These concerns have been recognized in neuro-oncology but have not been comprehensively evaluated. We conducted a semi- automated survey of adult interventional neuro-oncology trials, examining design, interventions, outcomes, and data availability trends. Trials were selected programmatically from ClinicalTrials.gov using primary malignant CNS tumour classification terms. Regression analyses assessed design and accrual trends; effect size analysis utilized survival rates among trials investigating survival.

This study aims to explore the determinants of sustainable agricultural practices among smallholder farmers in Ogun State, Nigeria. The study employed a survey research design and data were collected using a structured questionnaire. A total of 200 smallholder farmers were selected using a multistage sampling technique. The data collected were analyzed using descriptive statistics and binary logistic regression. The results showed that age, education level, farming experience, access to credit, access to extension services, and membership in farmer groups significantly influenced sustainable agricultural practices among smallholder farmers in Ogun State. Therefore, the study recommends that agricultural policymakers and stakeholders should design and implement programs that increase access to credit, extension services, and farmer groups among smallholder farmers in Ogun State.

The introduction of digital technologies and improvement of reconstruction methods, diagnostics of combined traumas of the maxillofacial region should be aimed at improving the quality of life and aesthetic parameters of patients, reducing traumatization, reconstructing anatomical areas, reducing the duration of the postoperative period.

Fast-dissolving drugs have become increasingly popular due to their convenience and ease of administration, particularly for patients who have difficulty swallowing or require rapid onset of action. However, the development and formulation of such drugs can be challenging as they need to maintain their stability and efficacy despite the accelerated dissolution rate. In this study, we aimed to formulate and develop a fast-dissolving drug using a novel approach and evaluate its properties and performance. We used a combination of direct compression and freeze-drying techniques to formulate and develop the drug, with the excipients mannitol, crospovidone, and microcrystalline cellulose. Our optimized formulation achieved a disintegration time of less than 30 seconds and a dissolution rate of over 90% within 2 minutes. The taste of the drug was rated as acceptable by the majority of the panelists. Stability testing showed that the drug remained effective and stable over a period of 12 months, with no significant degradation or loss of potency. Our study demonstrates the successful development and formulation of a fast-dissolving drug using a combination of direct compression and freeze-drying techniques, with promising results in terms of disintegration time, dissolution rate, taste, and stability.