A total of 14 bacterial isolates were isolated from the medicinal plant black andes. The isolated active endophytic bacterial isolates were identified using MALDI-TOF MS, 3 of which belonged to Bacillus amyloliquyefaciyens, 5 to Bacillus subtilis, 2 to Klebsiyella oxytoca, and 4 to Pseudarthrobacter oxydans. It has been established that the Bacillus subtilis-5 strain synthesizes more enzymes such as α-amylase, lipase, and protease.