DEVELOPMENT AND INNOVATIONS IN SCIENCE
International scientific-online conference
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CLINICAL AND IMMUNOLOGICAL ASPECTS OF PROGNOSIS AND
PREVENTION OF GENERALIZATION OF INFECTION IN PATIENTS
WITH CHRONIC WOUNDS
Umarov B.Ya.
Khamdamov B.Z.
Bukhara State Medical Institute, Republic of Uzbekistan, Bukhara
https://doi.org/10.5281/zenodo.14894038
Аннотация
The article deals with clinical and immunological aspects of prognosis and
prevention of generalization of infection in patients with chronic non-healing
wounds. Risk factors for infectious complications, mechanisms of inflammation,
and features of the immune response in the context of long-term wound healing
are discussed. Methods for diagnosing and monitoring the state of the immune
system, as well as the principles of treatment and prevention of infection,
including the use of antibacterial and immunomodulatory drugs, are described.
Recommendations for optimizing approaches in the treatment and prevention of
generalization of infection are proposed.
Key words:
chronic wounds, generalization of infection, immune response,
infection prevention, antibacterial therapy, inflammation, immunomodulation,
clinical aspects.
Relevance
Chronic non-healing wounds are a serious medical problem that requires a
comprehensive approach to the treatment and prevention of infectious
complications. Existing treatments often do not lead to complete healing, which
increases the risk of generalization of infection, the development of sepsis and
other serious diseases. An important role in preventing these complications is
played by the patient's immunological status, which can significantly affect the
rate of healing and the risk of infectious complications. The relevance of this
work is determined by the need to develop new effective methods of diagnosis
and therapy to prevent generalization of infection in such patients. The
development of techniques aimed at strengthening the immune response and
reducing the inflammatory process is crucial for improving the prognosis and
quality of life of patients with chronic wounds.
Objective
The aim of the study is to assess the clinical and immunological factors
affecting the generalization of infection in patients with chronic non-healing
wounds, as well as to develop effective methods for the prevention and
treatment of infectious complications.
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Materials and methods
The study used clinical data from 50 patients with chronic non-healing
wounds treated in dermatological and surgical clinics. The research methods
included clinical examination, laboratory blood tests (including indicators of
inflammation and immune response), microbiological examination of wound
material, as well as immunological tests to assess the state of the immune
system. Standard regimens of antibacterial therapy were used, as well as
therapy aimed at correcting the immune status of patients.
Results
The results showed that the majority of patients with chronic wounds show
a marked decrease in the activity of cellular and humoral immunity. A high rate
of infection of wound surfaces with many pathogenic microorganisms, including
antibiotic-resistant strains, was also revealed. The use of combination therapy,
including antibacterial drugs and immunomodulators, helped to accelerate
wound healing and reduce the risk of generalization of infection. In most cases,
there was an improvement in the clinical condition, a decrease in the level of
inflammation, and normalization of immune response indicators.
Conclusion
The studied clinical and immunological aspects confirm the importance of
an integrated approach in the treatment of chronic non-healing wounds.
Prevention of generalization of infection in such patients requires not only the
use of antibacterial agents, but also correction of the immune status. The use of
immunomodulatory drugs improves wound healing and reduces the frequency
of infectious complications. The results of the study emphasize the need for an
individual approach to each patient, taking into account the characteristics of
the immune system and infectious background.
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International scientific-online conference
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