One of the pathogenetic factors of bronchial metaplasia in smokers, susceptibility to poor-quality transforming diseases and measures to prevent early formation were examined by the authors. In smokers, a predisposition to bronchial metapilation is observed in 15% of patients, with long-term exposure to the airways, flat multilayered metaplasia of the columnar epithelium is observed. Accordingly, mitigation measures have been taken and early prevention investigated.