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AGE-RELATED MORPHOLOGICAL CHANGES AND CLINICAL
DYNAMICS OF POST-TRAUMATIC NASAL SEPTUM DEVIATION-
ASSOCIATED NASAL POLYPOSIS
Yuldashev Kahramonjon Shukurjon ugili
Fergana Public Health Medical Institute., assistant
.
Mahkamov Nosirjon Juraevich
Andijan State Medical Institute, DSc, Professor
https://doi.org/10.5281/zenodo.17008015
Introduction
Nasal polyposis (NP) is one of the most common manifestations of chronic
rhinosinusitis, characterized by persistent inflammation and tissue remodeling
within the sinonasal mucosa. Post-traumatic nasal septum deviation and related
structural damage often accelerate the development of nasal polyposis through
long-standing inflammatory processes. Age-related morphological variations of
the nasal mucosa are of particular interest, as they may influence both
histopathological features and the clinical course of the disease. Understanding
these differences is essential for optimizing age-specific therapeutic strategies.
Objective
To analyze age-related morphological changes in post-traumatic nasal
polyposis and evaluate their association with the clinical dynamics of the
disease.
Materials and Methods
- A total of 42 patients with post-traumatic nasal polyposis were studied.
- Patients were divided into two age groups:
а) Group I (18–35 years) – 21 patients
b) Group II (36–60 years) – 21 patients
- Polyp tissue samples were examined using standard histological staining
and morphometric analysis.
- The following parameters were evaluated: epithelial integrity,
inflammatory cell infiltration, granulation tissue formation, fibrosis, and
microvascular alterations.
Results
1. Younger patients (18–35 years):
- Marked epithelial hyperplasia and focal degeneration were frequently
observed.
- Pronounced granulation tissue formation with enhanced vascularization
was characteristic.
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- Inflammatory infiltration was dominated by eosinophils, indicating a
strong allergic-inflammatory component.
- Clinically, these patients demonstrated more frequent recurrences and
exacerbations.
2.Older patients (36–60 years):
-
Fibrosis and hyalinization of the submucosal layer were predominant.
- Microvascular changes included venous stasis and vascular wall sclerosis.
- Inflammatory infiltration was mainly lymphocytic in nature, suggesting a
more chronic immune response.
- Clinically, symptoms persisted but demonstrated a more stable, chronic
course compared to younger patients.
Conclusion
Age-related differences play a significant role in the morphological features
and clinical course of post-traumatic nasal polyposis.
-
Younger patients are characterized by active inflammatory and
proliferative processes with a tendency toward recurrence.
- Older patients show chronic fibrotic remodeling with less pronounced
recurrence but persistent symptoms.
These findings suggest that age-related histopathological assessment can
provide valuable insights for predicting disease dynamics and tailoring
individualized treatment strategies in patients with post-traumatic nasal
polyposis.
References:
1. Fokkens WJ, Lund VJ, Hopkins C, et al. European Position Paper on
Rhinosinusitis and Nasal Polyps 2020. Rhinology. 2020;58(S29):1–464.
2. Schleimer RP. Immunopathogenesis of chronic rhinosinusitis and nasal
polyposis. Annu Rev Pathol. 2017;12:331–357.
3. Van Bruaene N, Perez-Novo CA, Basinski TM, et al. T-cell regulation in chronic
paranasal sinus disease. J Allergy Clin Immunol. 2008;121(6):1435–1441.
4. Bachert C, Zhang N, Holtappels G, De Lobel L, van Cauwenberge P. Nasal
polyposis: Molecular and cellular mechanisms. Allergy. 2007;62(4):331–341.
5. Soyka MB, Wawrzyniak P, Eiwegger T, et al. Defective epithelial barrier in
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