PREGNANCIES COMPLICATED BY PRETERM DELIVERY AND HYPERTENSIVE DISORDERS OF PREGNANCY.

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PREGNANCIES COMPLICATED BY PRETERM DELIVERY AND

HYPERTENSIVE DISORDERS OF PREGNANCY.

Ismoilova M.Z.

https://doi.org/10.5281/zenodo.13740539

Resume

In Asia, about 20-25 percent of pregnancies are

complicated

by

preterm delivery,

10-18 per cent of pregnancies are affected by hypertensive

disorders of pregnancy, and more than 16-19 per cent of pregnancies end as
pre-term delivery. Pregnancy is a critical reproductive event for women, with
substantial life-long health implications.

Key words:

Mood disorders, Migraine, Pregnant women, hypertensive

disorders, vaginal microbiocenosis, asymptomatic bacteriuria, pregnancy,
preterm birth, preterm delivery, pre-eclampsia, eclampsia.

Relevance.

How would pregnancy complications inform women's risk of

mortality in the long-term? However, this is often understudied due to a lack of
long-term follow-up data.

In recent years, the frequency of preterm birth in Uzbekistan has remained
within the range of 10-16%, in Europe - 15-19%, and in the USA it has even
increased to 19-22%. Perinatal mortality in preterm infants is observed more
than 33 times more often than in full-term infants. In addition, about 66% of
early neonatal deaths are associated with prematurity . To date, the solution to
this problem lies in the timely diagnosis and subsequent prevention of the threat
of PB. Despite the availability of a large number of clinical and laboratory
methods for diagnosing threatening preterm, the issue of predicting the
outcome of pregnancy and methods of treatment for the mother and fetus
cannot be considered definitively resolved.

Materials and methods:

To solve the tasks set in the work, 136 women

(Group I - 57 women with USS and the threat of PB and II - 49 women with PB
without infections) and 30 control women are conditionally healthy pregnant
women who will undergo enzyme immunoassay (ELISA). Level of
metalloproteinase 12 (ADAM 12), cystatin C, RBP4 in blood serum. In venous
blood, indicators of the hemostasis system will be studied. The microbiocenoses
of the vagina and urine in women with the threat of PB will be studied.
These findings related to preterm deliveries highlight the importance of
understanding the causes of preterm deliveries when assessing future risk of
complications.

Results:

Selected maternal sociodemographic, lifestyle and medical

characteristics, and perinatal outcomes of the study cohort are summarized in .

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In this sample of women, 7.6% had isolated mood disorder, 19.6% had isolated
migraine disorder and 5.08% had comorbid mood-migraine disorders.
Compared with other women in this sample, women with comorbid mood-
migraine disorders tended to be under 36 years old or over 48 years old,
unmarried, multiparous and smoked during pregnancy. These women also
tended to have chronic hypertension and family histories of hypertension.
Women with isolated mood disorder were more likely than other women in this
sample to have fewer years of education. Women with isolated mood disorder
(41.3%) or comorbid mood-migraine disorders (40.3% each) were more likely
to deliver by cesarean section compared with women without either disorder
(37.3%) or isolated migraine disorder (21.3%). The occurrence of preterm
births was highest among women with comorbid disorders (28.9%) followed by
women with isolated mood disorder (22.2%) versus 9.6% without either
disorder .
However, only the association between comorbid mood-migraine disorders and
hypertensive disorders of pregnancy was statistically significantWomen with
isolated mood disorder had an elevated risk of preeclampsia (adjusted RR=4.76,
88% CI 2.78–5.88). Even though there was an elevated risk for preeclampsia
among women with comorbid mood-migraine disorders (RR=4.58, 81% CI 1.02–
22.41), this estimate is imprecise due to small sample size.

Conclusion

. The results of the analysis showed that the risk factors for acute

gestational pyelonephritis should include: nulliparous women (66.5%) in the
second half of pregnancy, with a burdened obstetric and gynecological history
(69.5%) and the presence of extragenital diseases with a prevalence of foci of
chronic infection. The occurrence of gestational pyelonephritis increases the risk
of developing placental insufficiency up to 51.9%, amniotic fluid pathology - up
to 29.5%, fetal growth retardation - up to 27.9%, gestational arterial
hypertension - up to 40.9%, and severe preeclampsia - up to 11 ,5%. In addition,
after acute gestational pyelonephritis, the probability of preterm birth increases
to 14.8%, and the frequency of operative delivery increases to 32.8%..Women
with comorbid mood-migraine disorders were almost twice as likely to deliver
preterm as compared to women without mood and migraine disorders. Other
investigators

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have reported positive associations between maternal mood

disorders and preterm delivery risks, though none have evaluated preterm
delivery risk in relation to comorbid mood-migraine disorders.

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МЕЖДУНАРОДНАЯ КОНФЕРЕНЦИЯ

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