МЕЖДУНАРОДНАЯ КОНФЕРЕНЦИЯ
АКАДЕМИЧЕСКИХ НАУК
56
RISKS OF GENERALIZATION OF INFECTION IN LONG-TERM NON-
HEALING WOUNDS: CLINICAL FEATURES AND PREVENTION
Umarov B.Ya.
Aripova T..U.
Bukhara State Medical Institute, Republic of Uzbekistan, Bukhara
https://doi.org/10.5281/zenodo.14894127
Abstract
The study is aimed at studying the formation of infectious complications in
patients with long-term non-healing wounds (DNZR). The study included 169
patients divided into control and main groups. Patients with pressure sores,
neurotrophic ulcers, and trophic ulcers after thrombophlebitis accounted for
38.5%, 32.5%, and 29%, respectively. The risk of generalization of infection in
the main group was 30% lower than in the control group, which indicates the
importance of complex therapy with antibacterial and immunomodulatory
agents. The data obtained made it possible to develop effective methods for the
prevention of infectious complications in chronic wounds.
Key words
: chronic wounds, long-term non-healing wounds, infectious
complications, prevention, pressure sores, neurotrophic ulcers, trophic ulcers,
antibacterial therapy, immunomodulators.
Relevance
Long-term non-healing wounds (DLDS) are a common medical problem,
especially among patients with chronic diseases such as diabetes,
thrombophlebitis, and hypodynamia. Complications, such as generalization of
infection, can lead to serious consequences, including sepsis. In this study, three
main forms of DNZR were considered: pressure sores, neurotrophic ulcers in
diabetic foot syndrome, and trophic ulcers after thrombophlebitis. These forms
account for 38.5%, 32.5% and 29% of the total number of patients, respectively.
Effective prevention and treatment of infectious complications is crucial for
improving patients ' quality of life and reducing morbidity. It is important to
emphasize the need to predict the risks of generalization of infection and
develop individualized methods of prevention and therapy for each group of
patients.
Objective
The aim of the study was to assess the frequency of generalization of infection
and to develop effective prevention methods in patients with various forms of
long-term non-healing wounds.
Materials and methods
The study involved 169 patients divided into the control group (84 people) and
МЕЖДУНАРОДНАЯ КОНФЕРЕНЦИЯ
АКАДЕМИЧЕСКИХ НАУК
57
the main group (85 people). The main forms of DNZR are bedsores of various
localization (38.5%), neurotrophic ulcers in diabetic foot (32.5%) and trophic
ulcers after thrombophlebitis (29%). The condition was assessed using clinical
tests, microbiological studies, C-reactive protein levels, and other laboratory
parameters. Patients in the main group received combination therapy, including
antibiotics and immunomodulators.
Results
From 169 patients, 38.5% had pressure sores, 32.5% had neurotrophic ulcers in
diabetic foot syndrome, and 29% had trophic ulcers after thrombophlebitis. In
the main group receiving combination therapy, the incidence of generalization of
infection decreased by 30%, which allowed to accelerate wound healing by 25%
compared to the control group. Clinical improvement was observed in 72% of
patients with pressure sores and 65% with neurotrophic ulcers.
Заключение
Generalization of infection is an important complication in long-term non-
healing wounds, especially in patients with chronic diseases. The use of
combination therapy, including antibacterial and immunomodulators,
significantly reduces the risk of generalization of infection and accelerates the
healing process. Effective prevention and individualized treatment of patients
with pressure ulcers, neurotrophic ulcers and trophic ulcers after
thrombophlebitis can significantly improve clinical outcomes and reduce the
incidence of complications.
Literature:
1.
Кулдашев Д. Р., Хошимов Б. Л. Морфологическая характеристика
репаративной регенерации костной ткани под влиянием цикло-3-форта
сравнительно с остеогеноном при экспериментальных костных дефектах
//Врач-аспирант. – 2011. – Т. 47. – №. 4.4. – С. 619-624.
2.
Хошимов Б. Л. МОРФОЛОГИЧЕСКИЕ ИЗМЕНЕНИЕ СОСУДОВ ПРИ
ЭКСПЕРИМЕНТАЛЬНОМ САХАРНОМ ДИАБЕТЕ //PEDAGOGS. – 2024. – Т. 52.
– №. 2. – С. 13-17.
3.
Khoshimov B. L., Akhmedova S. M. METABOLIK SINDROMDA
BIOKIMYOVIY O ‘ZGARISHLAR VA QON TOMIRLARDAGI MORFOLOGIK O
‘ZGARISHLAR BOG ‘LIQLIGI //Журнал гуманитарных и естественных наук. –
2024. – №. 14 [1]. – С. 183-189.
4.
Хошимов Б. Л., Ахмедова С. М. АТЕРОСКЛЕРОЗ СОСУДОВ —
ПРОЯВЛЕНИЕ ОСЛОЖНЕНИЙ МЕТАБОЛИЧЕСКОГО СИНДРОМА //
КОНФЕРЕНЦИЯ «РОЛЬ И ЗНАЧЕНИЕ НАУКИ В СОВРЕМЕННОМ МИРЕ». —
2024. — Т. 1. — №. 8. — С. 10-15.
МЕЖДУНАРОДНАЯ КОНФЕРЕНЦИЯ
АКАДЕМИЧЕСКИХ НАУК
58
5.
Лукмонович К. Б., Мухамадовна А. С. Реактивные изменения в аорте
при экспериментальном метаболическом синдроме // Журнал
«Биомедицина и практика». – 2024. – Т. 9. – №. 2.
