ISSN: 3030-3931, Impact factor: 7,241
Volume 6, issue 2, Mart 2025
https://worldlyjournals.com/index.php/Yangiizlanuvchi
worldly knowledge
OAK Index bazalari :
research gate, research bib.
Qo’shimcha index bazalari:
zenodo, open aire. google scholar.
Original article
265
MODERN TREATMENT OF PSORIASIS.
Ahrorbek Abdurahmanov Avazbek o‘g‘li
,
Department of Dermatovenerology,
Andijan State Medical Institute, Uzbekistan
Relevance.
Psoriasis is a chronic inflammatory disease that affects the skin and sometimes the
joints (psoriatic arthritis). According to WHO, psoriasis affects 2 to 3% of the world's population.
Modern research indicates its autoimmune nature, involving cytokines (TNF-α, IL-17, IL-23, etc.)
in the inflammatory process. In recent years, psoriasis therapy has undergone significant changes,
especially due to the development of targeted biological drugs and new synthetic agents (e.g.,
JAK inhibitors), which makes the topic of modern psoriasis treatment extremely relevant [1,2].
Objective.
The main objective is to analyze the latest advances in psoriasis treatment, paying
special attention to biological drugs, new oral agents and combination approaches, and to
evaluate their effectiveness, safety and impact on the quality of life of patients.
Methods.
Scientific literature review: systematic review of peer-reviewed articles, meta-analyses,
and clinical trial results published over the past 5-7 years.
International guideline review: comparison of recommendations from different dermatological
associations (e.g., AAD, EADV) to identify common trends and inconsistencies [3]. Patient data
collection: review of real-world cases and registries to assess long-term efficacy, side effects,
and patient compliance.
Results.
High efficacy of biologics: targeted therapy (TNF-α, IL-17, IL-23 inhibitors) shows
high skin clearance (PASI 75–100) and improved quality of life.
New oral agents: JAK inhibitors and other small molecules offer alternative options for patients
who are unsuitable for or have no access to biologic therapy.
Improved long-term outcomes: modern treatment regimens achieve sustained remission and
reduce the risk of systemic complications.
Limitations: Despite the successes, there are still problems related to the availability of therapy
(high cost, need for regular monitoring), as well as individual variability in the response to
treatment.
Conclusions.
The modern approach to psoriasis therapy has significantly expanded due to the
development of targeted biological agents and innovative oral drugs [4]. The use of these
methods in combination with comprehensive patient management (lifestyle, psychological
support, control of comorbidities) allows not only to achieve a significant improvement in the
skin condition, but also to improve the overall quality of life. However, despite the progress, it is
important to continue research in the field of safety, availability and cost-effectiveness of therapy,
as well as to develop a personalized approach that takes into account the individual
characteristics of patients.
ISSN: 3030-3931, Impact factor: 7,241
Volume 6, issue 2, Mart 2025
https://worldlyjournals.com/index.php/Yangiizlanuvchi
worldly knowledge
OAK Index bazalari :
research gate, research bib.
Qo’shimcha index bazalari:
zenodo, open aire. google scholar.
Original article
266
References:
1.
Stepanova Zh. V. Fungal diseases. - Moscow: Kron-Press. - 1996. - P. 176.
2.
Stepanova Zh. V. - Doctor of Medical Sciences, Leading Researcher of the Mycology
Group of the Central Research Institute of Skin and Venereal Diseases of the Ministry of Health
of the Russian Federation, Moscow.
3.
Bahadyrovna, N.N., 2024. THE SIGNIFICANCE OF PSORIASIS AT PRESENT.
Ethiopian International Journal of Multidisciplinary Research, 11(03), pp.202-204.
4.
Akiljanovna, M.L., 2024. THE COURSE OF PSORIASIS IN YOUNG AND OLD
CHILDREN. Ethiopian International Journal of Multidisciplinary Research, 11(03), pp.205-207.
5.
Mukhamedova, M., Orziev, D. Z., Uzokov, J. K., & Abdullaev, A. X. (2023).
Optimization of antiplatelet therapy in patients with coronary artery disease and type 2 diabetes
mellitus after percutaneous coronary interventions. European Journal of Cardiovascular Nursing,
22(Supplement_1), zvad064-111.
6.
Nasirova, G. A., & Mukhamedova, M. G. (2023). Chronic heart failure and COVID-19.
International Journal of Scientific Research Updates, 5(1), 138-42.
7.
Фозилов, Х. Г., Шек, А. Б., Бекметова, Ф. М., Алиева, Р. Б., Мухамедова, М. Г.,
Муллабаева, Г. У., ... & Хотамова, М. Н. (2021). Особенности деформационных свойств
левого желудочка у больных с поражением коронарных артерий. Клиническая и
экспериментальная хирургия, 9(3), 118-124.
8.
Karimov, B., Abidova, D., Muyassar, M., Uzakova, M., Orziev, D., Ubaydullaev, S., &
Naezulloeva, D. (2022, June). Plasma B-type natriuretic peptide in patients with coronary artery
disease and metabolic syndrome. In EUROPEAN JOURNAL OF CLINICAL
INVESTIGATION (Vol. 52). 111 RIVER ST, HOBOKEN 07030-5774, NJ USA: WILEY.
9.
Qizi, B. O. S., Qizi, X. D. A., & Yusupovich, M. I. (2022). IJTIMOIY SIYOSAT:
ROSSIYADA INKLYUZIV TA? LIM HAQIDA. FAN, TA'LIM VA AMALIYOTNING
INTEGRASIYASI, 922-930.
10.
Yusup o‘g’li, M. I. (2022). Mustaqil ta’limni blended learning texnologiyasi asosida
tashkil etish. FAN, TA'LIM VA AMALIYOTNING INTEGRASIYASI, 126-131.
11.
Taxirovich, A. S. (2025). TEACHING THE TOPIC OF INTESTINAL INFECTIONS
USING THE EXAMPLE OF ACL (ACTIVE COLLABORATIVE LEARNING). Ethiopian
International Journal of Multidisciplinary Research, 12(01), 557-559.
12.
Kuzieva, S. U., Imomova, D. A., & Duschanova, G. M. (2019). Structural features of
vegetative organs Spiraea hypericifolia L., growing in Uzbekistan. American Journal of Plant
Sciences, 10(11), 2086-2095.
13.
Yusup o‘g‘li, M. I. (2024). OLIY TА’LIM MUАSSАLАRIDА INKLYUZIV TА’LIMNI
RIVOJLАNTIRISH: MUАMMO VА YECHIMLАR. FAN, TA'LIM VA AMALIYOTNING
INTEGRASIYASI, 5(1), 1-10.
14.
Бозоров, Ш. Т., Гафуров, А. А., Юлдашев, М. А., Абдукодиров, Ш. Т., &
Розимаматова, Г. С. (2022). КОЛОСТОМИЯ ПРИ ОСЛОЖНЕНИЯХ ХИРУРГИЧЕСКОЙ
КОРРЕКЦИИ АНОРЕКТАЛЬНОЙ МАЛЬФОРМАЦИЙ У ДЕТЕЙ. Экономика и социум,
(8 (99)), 139-144.
15.
Кузиева, С. У., & Ишонкулова, Д. У. (2018).
ВЫДЕЛЕНИЕ И
ЭЛЕКТРОФОРЕТИЧЕСКИЕ СВОЙСТВА МАЛАТДЕГИДРОГЕНАЗЫ ХЛОПЧАТНИКА.
In INTERNATIONAL SCIENTIFIC REVIEW OF THE PROBLEMS AND PROSPECTS OF
MODERN SCIENCE AND EDUCATION (pp. 14-16).
