This paper presents a comprehensive framework designed to preserve kidney vitality by effectively managing and preventing drug-induced end-stage renal disease (ESRD). With an increasing incidence of renal complications linked to pharmaceutical agents, a holistic approach is crucial. The proposed framework integrates medical, pharmacological, and lifestyle interventions, emphasizing early detection, risk mitigation, and patient education. By addressing both the underlying causes and proactive preventive measures, this approach aims to minimize the impact of drug-induced ESRD, promoting renal health and well-being.