Volume 03 Issue 12-2023
44
International Journal of Medical Sciences And Clinical Research
(ISSN
–
2771-2265)
VOLUME
03
ISSUE
12
P
AGES
:
44-48
SJIF
I
MPACT
FACTOR
(2021:
5.
694
)
(2022:
5.
893
)
(2023:
6.
184
)
OCLC
–
1121105677
Publisher:
Oscar Publishing Services
Servi
ABSTRACT
The COVID-19 pandemic has shown that this is a disease that affects almost all organs and systems. At the same time,
the problem of damage to the nervous system that leads to serious consequences in the form of various vascular
inflammation and degenerative pathologies (stroke, encephalitis, polyneuropathy) of the brain and peripheral nerves
are increasing. The question of the origin of cognitive impairment at a young age in people who did not have any
problems with intellectual functions before COVID-19 is more complicated. This issue is closely related to the issue of
the pathogenesis of damage to the nervous system in COVID-19. At the same time, the cognitive function of a person
also closely depends on the emotional state, educational qualification, gender and age. These factors are not well
covered in the literature. With this in mind, we conducted this study.
KEYWORDS
Cognitive impairment, anxiety-depressive devices, COVID-19, MMSE, MoCa.
INTRODUCTION
Research Article
FACTORS AFFEKTING THE DEVELOPMENT OF COGNITIVE FYNCTION IN
PERSONS WHO SURVIVED COVID-19
Submission Date:
December 11, 2023,
Accepted Date:
December 16, 2023,
Published Date:
December 21, 2023
Crossref doi:
https://doi.org/10.37547/ijmscr/Volume03Issue12-09
Gafurov Bakhtiyor Gafurovich
Development Of Professional Qualification Of Their Medical Workers Of The Ministry Of Health Of The
Republic Of Uzbekistan
Mamadjonova Tursunoy Toxir Qizi
Researcher, Development Of Professional Qualification Of Their Medical Workers Of The Ministry Of Health Of
The Republic Of Uzbekistan
Journal
Website:
https://theusajournals.
com/index.php/ijmscr
Copyright:
Original
content from this work
may be used under the
terms of the creative
commons
attributes
4.0 licence.
Volume 03 Issue 12-2023
45
International Journal of Medical Sciences And Clinical Research
(ISSN
–
2771-2265)
VOLUME
03
ISSUE
12
P
AGES
:
44-48
SJIF
I
MPACT
FACTOR
(2021:
5.
694
)
(2022:
5.
893
)
(2023:
6.
184
)
OCLC
–
1121105677
Publisher:
Oscar Publishing Services
Servi
Material and methods of investigation: The material for
the study was 120 patients from COVID-19 and 40
people of the same age as the control group. The
group of patients infected with COVID-19 is those who
have been discharged from the hospital after the main
clinical symptoms of the disease and a negative PCR
test. the distribution of sex, age and education levels
of patients is presented in the table.
All patients underwent a clinical and neurological
examination, a detailed history was taken. MMSE test
(Mini-Mental State Examination) and Montreal
Cognitive Assessment MoCA
(Montreal Cognitive Assessment) were used to assess
the level of cognitive impairment. The studies were
conducted in a private room in a confidential and quiet
environment. The MMSE test was evaluated according
to the following criteria: a total score of 30. Evaluation
criteria: 27
–
25 - moderate cognitive impairment, 24 or
less - severe cognitive impairment. The Montreal
Cognitive Scale (MoCA) is widely used as a screening
tool for cognitive impairment, the questionnaire is a
one-page test with 30 items that takes an average of 10
minutes to complete.
To assess anxiety, we use Yu.L. Khanina (1976). An
important advantage of this scale is the ability to
distinguish two types of anxiety - anxiety as a
personality trait (constitutional, personal anxiety) and
anxiety as a temporary clinical condition (reactive
anxiety). Interpretation of results: the final score is up
to 30 points. - low anxiety; 31-45 - moderate anxiety; 46
and more - high anxiety.
Results and Discussion: Clinical and neurological
examination revealed significant differences between
healthy and post-COVID-19 patient groups.
48
72
58
62
83
37
21
19
15
25
29
11
M A N
W O M A N
U P T O 4 0 Y E A R S
O L D
O V E R 4 0 Y E A R S
O L D
S E C O N D A R Y
E D U C A T I O N
H I G H L Y
E D U C A T E D
Those infected with
С
OVID-19
comparison group
Volume 03 Issue 12-2023
46
International Journal of Medical Sciences And Clinical Research
(ISSN
–
2771-2265)
VOLUME
03
ISSUE
12
P
AGES
:
44-48
SJIF
I
MPACT
FACTOR
(2021:
5.
694
)
(2022:
5.
893
)
(2023:
6.
184
)
OCLC
–
1121105677
Publisher:
Oscar Publishing Services
Servi
Among the complaints of patients in the main group,
psychoemotional disorders prevailed, 116 patients
(97%) had symptoms of asthenia in the form of
weakness and reduced work capacity, 110 patients
(92%) had fatigue, 95 patients complained of
headaches (79%), dizziness - 80 patients ( 67%),
nocturnal sleep disorder in 96 patients (80%), tinnitus
in 72 patients, excessive irritability and nervousness in
behavior in 60% of patients 78 (65%), isolation - 24
patients who passed through COVID-19 (20%).
It should be noted that all patients of the main group
complained of memory loss. Analysis of focal
neurological symptoms showed that: 54 (45%) of the
examined patients had central paresis of the VII pair of
cranial nerves, central paresis of the XII pair of cranial
nerves, respectively, in 30 (25%).
Reflexes of oral automatism occurred in 12 (10%)
patients, respectively, anisoreflexia in 68 (57%)
patients, instability in the Romberg position in 54 (45%)
patients, and intention during finger-nose examination
in 34 patients.
Subjective and objective neurological disorders were
minimally expressed in the control group. Considering
the increased anxiety effect after suffering from
COVID-19, we first analyzed the structure of anxiety
disorders in the examined groups (Figure 2).
25.1
26.8
24.2
25.1
24.8
24.8
26.2
23.4
24.4
23.1
25.1
22.1
24.5
23.8
26.8
26.8
25.8
26.4
26.6
25.2
26.8
27.8
27.8
26.5
27.2
25.2
28.4
26.2
0
5
10
15
20
25
30
general group
man
women
Up to 40 years
old
Over 40 years
old
secondary
education
highly educated
Level of anxiety in the surveyed groups according to
the Spielberger test
high anxiety group MMSE
high anxiety group MoCa
low anxiety group MMSE
low anxiety group MoCa
Volume 03 Issue 12-2023
47
International Journal of Medical Sciences And Clinical Research
(ISSN
–
2771-2265)
VOLUME
03
ISSUE
12
P
AGES
:
44-48
SJIF
I
MPACT
FACTOR
(2021:
5.
694
)
(2022:
5.
893
)
(2023:
6.
184
)
OCLC
–
1121105677
Publisher:
Oscar Publishing Services
Servi
The data presented in the figure show that both
reactive and personal anxiety are significantly
prevalent in people with COVID-19. At the same time,
significant differences were found in men only in RT,
and in women in both indicators of anxiety.
Analysis by age revealed a significant prevalence of
anxiety in the older subgroup. Reliably, compared to
the control group, anxiety was more prevalent in the
subgroup of highly educated individuals. Comparisons
between identified subgroups showed that RT and LT
were significantly superior in women in the main and
control groups.
A significant increase in the level of LT was found in the
subgroup of older patients compared to younger
patients. The RT rate was significantly higher in the
group of patients in the older age subgroup.
To study the relationship between cognitive
impairment and anxiety, we divided the patients with
Covid into two groups: high anxiety and low anxiety.
The results showed that cognitive impairment was
significantly more pronounced in high anxiety patients
compared to low anxiety patients. Women in the
MMSE and MOCA high anxiety group had more clear
cognitive impairment than men.
In addition, cognitive impairment in the subgroup of
patients with high anxiety over the age of 40 was
significantly greater than in younger patients with low
anxiety.
At the same time, it should be noted that the level of
cognitive impairment in patients with different levels
of education was almost the same, and the main
differences were only related to the level of anxiety.
Conclusion: Thus, the study of cognitive status and
psycho-emotional status using clinical scales showed
that cognitive deficits are characteristic of patients
who have passed through COVID-19, are not related to
the level of education, and worsen cognitive
dysfunction in existing patients. cognitive disorders,
disorders that require mandatory correction in the
early stages of recovery.
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44-48
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Oscar Publishing Services
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