Volume 03 Issue 09-2023
27
International Journal of Medical Sciences And Clinical Research
(ISSN
–
2771-2265)
VOLUME
03
ISSUE
09
P
AGES
:
27-29
SJIF
I
MPACT
FACTOR
(2021:
5.
694
)
(2022:
5.
893
)
(2023:
6.
184
)
OCLC
–
1121105677
Publisher:
Oscar Publishing Services
Servi
ABSTRACT
Comorbid pathology is widespread in patients with myocardial infarction. One of the current directions of modern
cardiology is to study the contribution of comorbidity to the prognosis in patients who have suffered a myocardial
infarction, as well as the assessment of endothelial dysfunction as one of the key links in the pathogenesis of
atherosclerosis. 106 patients with myocardial infarction were included in the study.
KEYWORDS
Endothelial dysfunction, comorbidity, myocardial infarction.
INTRODUCTION
In modern society, there is a high level of disability and
mortality from cardiovascular pathology[4]. The
probability of developing fatal cardiovascular
complications increases with various combinations of
risk factors with comorbid conditions [1,5].
Mortality from cardiovascular diseases (CVD) and their
complications in the structure of total mortality occupy
the first place among the four main causes; and for
them, in particular, they are 50% higher than those from
cerebrovascular diseases in general[8].
MI is a pathological condition characterized by an
absolute or relative violation of the blood supply to the
myocardium due to damage to the coronary arteries of
the heart (definition of the World Health Organization,
1965) [3,7].
Research Article
PREVENTION OF RISK FACTORS OBSERVED IN MYOCARDIAL
INFARCTION WITH COMORBID PATHOLOGY
Submission Date:
September 20, 2023,
Accepted Date:
September 25, 2023,
Published Date:
September 30, 2023
Crossref doi:
https://doi.org/10.37547/ijmscr/Volume03Issue09-06
Yaminova Nafisa Khaydaralievna
Andijan State Medical Institute, Uzbekistan
Journal
Website:
https://theusajournals.
com/index.php/ijmscr
Copyright:
Original
content from this work
may be used under the
terms of the creative
commons
attributes
4.0 licence.
Volume 03 Issue 09-2023
28
International Journal of Medical Sciences And Clinical Research
(ISSN
–
2771-2265)
VOLUME
03
ISSUE
09
P
AGES
:
27-29
SJIF
I
MPACT
FACTOR
(2021:
5.
694
)
(2022:
5.
893
)
(2023:
6.
184
)
OCLC
–
1121105677
Publisher:
Oscar Publishing Services
Servi
Recently, this definition has not been changed. CVD
pathogenetically associated with atherosclerosis, as
well as their complications, are the leading cause of
mortality and disability in Western Europe among
adults, the United States and Japan, as well as in
Russia.
The annual mortality from MI is 2-3%, and non-fatal
myocardial infarction has a frequency of about 3%. It is
important to emphasize that the mortality rates from
MI among male patients aged 45-74 years in Russia
from 1965 to 1998 increased from 499 to 1152, and
among women of the same age group - from 237 to 402
per 100 thousand population [2,6]
The purpose of the study.To study the regional
features of the prevalence of the main risk factors and
the structure of comorbid pathology in patients with
MI in order to optimize secondary prevention in
patients with MI.
Materials and methods of research. 106 patients with
MI were included in the study. Inclusion was carried
out with informed consent. Exclusion criteria: age of
the patient over 75 years, acute or chronic exogenous
intoxication, refusal of the patient from the study.
The results of the study. All patients underwent a
general clinical examination (blood test, including
lipidogram, echocardiography, daily monitoring
electrocardiography (ECG)). To assess the functional
class (FC) of CHF, a six-minute walking test (TSH) was
used. On the 10th-14th day of MI, after 3, 6 months and
1 year, the functional state of the endothelium was
determined by peripheral arterial tonometry (PAT) on
the endo-RAT-2000 device with the ItamarMedicalLtd
software.
The most common behavioral risk factors for patients
with MI living in the Republic of Uzbekistan are eating
disorders (100%), physical inactivity (53% with a
predominance in women), and for men smoking is
added to these factors (24.3%).
The prevalence of the main risk factors is Arterial
hypertension (AH), Hypercholesterolemia (HHS),
petroleum
hydrocarbon
in
the
soil
(NUV),
Cardiovascular complications have no sex differences
(SSR), the aortic opening (AO) is more common in
women, the age of onset of MI in women is less than in
men
The main efforts in the correction of FR MTR are aimed
at achieving the target blood pressure level (57.4%),
however, due to the lack of proper laboratory control,
the
correction
of
hyperglycemia
(34%)
and
hypercholesterolemia (7.5%) are at an extremely low
level.
In patients with MI, gastrointestinal and COPD diseases
are most often detected. Gastric ulcer, urolithiasis and
COPD in men with MI are detected 2 times more often
than in women (p<0.01)
Volume 03 Issue 09-2023
29
International Journal of Medical Sciences And Clinical Research
(ISSN
–
2771-2265)
VOLUME
03
ISSUE
09
P
AGES
:
27-29
SJIF
I
MPACT
FACTOR
(2021:
5.
694
)
(2022:
5.
893
)
(2023:
6.
184
)
OCLC
–
1121105677
Publisher:
Oscar Publishing Services
Servi
Somatic diseases have the greatest reliable correlation
with behavioral factors (eating disorders, physical
inactivity, smoking, excessive alcohol intake) and AO,
hypercholesterolemia,
hyperglycemia
and
hypertension.
Consequently, the correction of risk factors for MTR
will not only reduce the risk of developing MTR, but will
also contribute to achieving remission of comorbid
diseases.
CONCLUSION
The tactics of treatment and prevention in patients
with angina pectoris should be multicomponent in
nature, taking into account a wide range of socio-
demographic indicators, the main risk factors and
concomitant diseases. Such tactics can improve the
quality and life expectancy of patients with comorbid
pathology.
To improve the diagnosis and correction of the main
risk factors for MTR and concomitant diseases, it is
necessary to expand programs to improve the
knowledge of doctors and medical staff. It is also
necessary to organize health schools for MI patients
with comorbid pathology.
REFERENCES
1.
Akimova E.V., Pushkarev G.S., Smaznov V.Yu.,
Gafarov V.V., Kuznetsov V.A. Socio-economic risk
factors of cardiovascular death: data from a 12-year
prospective study. Russian Journal of Cardiology.
2014. No. 6 (110). pp. 7-11.
2.
Gilyarevsky S.R., Rezvan V.V., Kuzmina I.M.,
Golshmid M.V.. Modern approaches to anti-
ischemic therapy of patients with a stable course of
coronary heart disease. Russian Medical Journal.
2014. Vol. 22. No. 12. pp. 928-932.
3.
Kantemirova R.K., Krivenkov S.G., Fedorova Z.D.
Factors significant for clinical and labor prognosis
in elderly patients with coronary heart disease who
underwent surgical myocardial revascularization.
The successes of gerontology. 2014. Vol. 27. No. 1.
pp. 120-123.
