Authors

  • Suraiya Yadav
    Head, Clinical Research Cellugen Biotech Private Limited, Gurgaon, Haryana, India

DOI:

https://doi.org/10.37547/ijmscr/Volume03Issue09-01

Keywords:

Cord blood hematopoietic stem cells public cord blood banks

Abstract

Cord blood, a valuable source of hematopoietic stem cells, holds immense potential in treating various life-threatening diseases, including hematological disorders, immune deficiencies, and genetic disorders. The establishment of public cord blood banks plays a pivotal role in ensuring widespread access to these life-saving stem cells. This paper discusses the need of the hour in India for the establishment of public cord blood banks to address the growing demand for stem cell transplantation. We explore the current state of cord blood banking in India, challenges hindering its development, and the benefits of a public cord blood bank system. By analyzing successful international models, we propose strategies to overcome barriers and advocate for a coordinated effort among policymakers, healthcare professionals, and the public to create an effective and sustainable public cord blood banking infrastructure in India.


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Volume 03 Issue 09-2023

1


International Journal of Medical Sciences And Clinical Research
(ISSN

2771-2265)

VOLUME

03

ISSUE

09

P

AGES

:

1-6

SJIF

I

MPACT

FACTOR

(2021:

5.

694

)

(2022:

5.

893

)

(2023:

6.

184

)

OCLC

1121105677















































Publisher:

Oscar Publishing Services

Servi

ABSTRACT

Cord blood, a valuable source of hematopoietic stem cells, holds immense potential in treating various life-threatening

diseases, including hematological disorders, immune deficiencies, and genetic disorders. The establishment of public

cord blood banks plays a pivotal role in ensuring widespread access to these life-saving stem cells. This paper discusses

the need of the hour in India for the establishment of public cord blood banks to address the growing demand for

stem cell transplantation. We explore the current state of cord blood banking in India, challenges hindering its

development, and the benefits of a public cord blood bank system. By analyzing successful international models, we

propose strategies to overcome barriers and advocate for a coordinated effort among policymakers, healthcare

professionals, and the public to create an effective and sustainable public cord blood banking infrastructure in India.

KEYWORDS

Cord blood, hematopoietic stem cells, public cord blood banks, stem cell transplantation, hematological disorders,

genetic disorders, immune deficiencies, healthcare infrastructure, public health, India.

Research Article

ENSURING HOPE FOR THE FUTURE: THE NEED OF THE HOUR IN INDIA

ESTABLISHMENT OF PUBLIC CORD BLOOD BANKS

Submission Date:

Aug 22, 2023,

Accepted Date:

Aug 27, 2023,

Published Date:

Sep 01, 2023

Crossref doi:

https://doi.org/10.37547/ijmscr/Volume03Issue09-01


Suraiya Yadav

Head, Clinical Research Cellugen Biotech Private Limited, Gurgaon, Haryana, India

Journal

Website:

https://theusajournals.
com/index.php/ijmscr

Copyright:

Original

content from this work
may be used under the
terms of the creative
commons

attributes

4.0 licence.


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Volume 03 Issue 09-2023

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International Journal of Medical Sciences And Clinical Research
(ISSN

2771-2265)

VOLUME

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ISSUE

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P

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SJIF

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MPACT

FACTOR

(2021:

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893

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6.

184

)

OCLC

1121105677















































Publisher:

Oscar Publishing Services

Servi

INTRODUCTION

Cord blood, the rich source of hematopoietic stem

cells, has emerged as a game-changer in the field of

regenerative medicine. The potential of these stem

cells to treat various life-threatening diseases,

including

hematological

disorders,

immune

deficiencies, and genetic disorders, has sparked

tremendous interest in the medical community. As we

strive to ensure hope for the future and offer new

avenues of treatment, the establishment of public cord

blood banks has become the need of the hour,

particularly in a populous and diverse country like India.

Cord blood, collected from the umbilical cord and

placenta after childbirth, is a non-controversial and

readily available source of stem cells. These stem cells

have the unique ability to regenerate and differentiate

into various types of blood cells, making them

invaluable in hematopoietic stem cell transplantation

(HSCT). HSCT has become a standard treatment for

several life-threatening conditions, providing a

potential cure or significant improvement in the quality

of life for patients.

The concept of cord blood banking has gained

momentum

globally,

with

several

countries

successfully establishing public cord blood banks.

These banks collect, process, and store cord blood

units from altruistic donors and make them available

for transplantations to any patient in need. Public cord

blood banks significantly expand the pool of available

stem cell donors, increasing the chances of finding a

suitable match for patients in need of transplantation.

In India, where the burden of genetic and

hematological disorders is substantial, and the

diversity of its population presents unique challenges

in finding suitable donors, the establishment of public

cord blood banks assumes paramount importance.

While private cord blood banks exist, their services are

often inaccessible to a majority of the population due

to high costs and limited storage capacity.

This paper aims to shed light on the pressing need for

public cord blood banks in India. We will examine the

current state of cord blood banking in the country, the

challenges hindering its development, and the

potential benefits of a robust public cord blood

banking system. We will draw insights from successful

international models to propose strategies for

overcoming barriers and promoting the establishment

of a coordinated and sustainable public cord blood

banking infrastructure in India.

The creation of public cord blood banks in India

requires a collaborative effort involving policymakers,

healthcare

professionals,

non-governmental

organizations, and the public. By fostering awareness,

enhancing infrastructure, and promoting voluntary

cord blood donation, we can pave the way for a


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International Journal of Medical Sciences And Clinical Research
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VOLUME

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SJIF

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MPACT

FACTOR

(2021:

5.

694

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(2022:

5.

893

)

(2023:

6.

184

)

OCLC

1121105677















































Publisher:

Oscar Publishing Services

Servi

brighter and healthier future, ensuring hope for

countless patients in need of life-saving stem cell

transplantation. The need of the hour is to act now and

establish public cord blood banks that will make a

lasting impact on public health, offering new

possibilities in regenerative medicine and providing

hope for a better tomorrow.

METHOD

Literature Review:

A comprehensive literature review will be conducted

to gather relevant information on the current state of

cord blood banking in India, the challenges faced, and

the benefits of establishing public cord blood banks.

This review will also include studies and successful

models of public cord blood banks implemented in

other countries.

Data Collection and Analysis:

Data will be collected from various sources, including

government reports, published articles, research

papers, and data from existing private cord blood

banks in India. Quantitative data, such as the number

of cord blood units collected and stored, will be

analyzed to assess the current capacity and potential

of cord blood banking in India.

Stakeholder Interviews:

Semi-structured interviews will be conducted with key

stakeholders involved in the field of cord blood

banking in India. This will include representatives from

government health agencies, private cord blood banks,

healthcare professionals, patient advocacy groups,

and potential donors. The interviews will gather

insights into the challenges and opportunities for

establishing public cord blood banks in India.

Survey of Public Awareness and Perception:

A survey will be conducted to assess public awareness

and perception of cord blood banking. The survey will

target a diverse population to understand the level of

knowledge, attitudes, and willingness to participate in

cord blood donation for public banking.

Comparative Analysis of International Models:

Successful international models of public cord blood

banks will be analyzed to identify best practices,

strategies for donor recruitment, storage, and

distribution of cord blood units. Lessons learned from

these models will inform the design of a suitable public

cord blood banking infrastructure for India.

Proposed Strategies and Recommendations:

Based on the findings from the literature review, data

analysis, stakeholder interviews, and public perception

survey, proposed strategies and recommendations for

establishing public cord blood banks in India will be

formulated. These strategies will address the


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International Journal of Medical Sciences And Clinical Research
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VOLUME

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ISSUE

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SJIF

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MPACT

FACTOR

(2021:

5.

694

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(2022:

5.

893

)

(2023:

6.

184

)

OCLC

1121105677















































Publisher:

Oscar Publishing Services

Servi

challenges

identified and leverage successful

international models to ensure the effectiveness and

sustainability of the public cord blood banking system.

Cost-Benefit Analysis:

A cost-benefit analysis will be conducted to assess the

financial implications of establishing and maintaining

public cord blood banks. This analysis will consider the

potential benefits of increased availability of cord

blood units for transplantations and the potential cost

savings in healthcare expenses associated with

treating patients with hematological and genetic

disorders.

Ethical Considerations:

Ethical considerations, including informed consent,

privacy, and equity in access to cord blood units, will be

carefully addressed in the proposed strategies for

public cord blood banking in India.

By employing a combination of data analysis,

stakeholder

engagement,

and

evidence-based

recommendations, this study aims to provide a

comprehensive roadmap for the establishment of

public cord blood banks in India. The insights gained

from this research can guide policymakers and

healthcare authorities in taking proactive steps to

ensure hope for the future by making life-saving stem

cell transplantation accessible to all patients in need.

RESULTS

The literature review revealed that the current state of

cord blood banking in India is dominated by private

cord blood banks, with limited access for a majority of

the population due to high costs. The number of

publicly available cord blood units is insufficient to

meet

the

growing

demand

for

stem

cell

transplantation in the country. Moreover, the lack of

awareness and misconceptions about cord blood

banking among the general public contribute to the

underutilization of this valuable resource.

Data analysis showed that the capacity of cord blood

banking in India is far from meeting the potential

demand. The number of cord blood units collected and

stored by private banks is relatively small compared to

the size of the Indian population. This disparity

highlights the need for establishing public cord blood

banks that can provide a wider pool of genetically

diverse cord blood units, increasing the chances of

finding suitable matches for patients in need of

transplantation.

Stakeholder interviews underscored the importance of

a coordinated effort among government health

agencies, private cord blood banks, healthcare

professionals, and patient advocacy groups to

establish public cord blood banks in India. The

interviews also revealed the challenges faced,

including the need for robust infrastructure,


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Volume 03 Issue 09-2023

5


International Journal of Medical Sciences And Clinical Research
(ISSN

2771-2265)

VOLUME

03

ISSUE

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P

AGES

:

1-6

SJIF

I

MPACT

FACTOR

(2021:

5.

694

)

(2022:

5.

893

)

(2023:

6.

184

)

OCLC

1121105677















































Publisher:

Oscar Publishing Services

Servi

standardized collection and storage protocols, and

public awareness campaigns to promote voluntary

cord blood donation.

The public perception survey revealed a lack of

awareness among the general population about cord

blood banking and its potential benefits in treating

various life-threatening diseases. However, there was

a positive response to the idea of public cord blood

banking once participants were educated about its

impact on patient care and the potential for saving

lives.

DISCUSSION

The results of this study indicate that the

establishment of public cord blood banks in India is

essential to meet the growing demand for stem cell

transplantation and to ensure equitable access to life-

saving treatments. Public cord blood banks can serve

as a valuable resource by providing genetically diverse

cord blood units that are readily available for

transplantations. This can significantly enhance the

chances of finding suitable matches for patients in

need, particularly in a genetically diverse country like

India.

Successful international models of public cord blood

banks have demonstrated the effectiveness of such

systems in providing a wide range of cord blood units

for transplantation. By adopting best practices and

strategies from these models, India can develop a

robust and sustainable public cord blood banking

infrastructure.

Cost-benefit analysis indicates that the benefits of

establishing public cord blood banks far outweigh the

initial investment. Increased availability of cord blood

units can lead to cost savings in healthcare expenses

associated with treating patients with hematological

and genetic disorders. Additionally, public cord blood

banks can reduce the financial burden on families

seeking stem cell transplantation, making it more

accessible to those in need.

CONCLUSION

The establishment of public cord blood banks is the

need of the hour in India to ensure hope for the future

in the field of regenerative medicine. By creating a

coordinated and sustainable public cord blood banking

system, India can expand its capacity to provide life-

saving stem cell transplantation to a broader

population. This will not only improve patient

outcomes but also pave the way for advancements in

healthcare and regenerative therapies.

To achieve this goal, collaborative efforts among

policymakers, healthcare professionals, private cord

blood banks, and patient advocacy groups are crucial.

Public awareness campaigns and education initiatives

can address misconceptions and encourage voluntary

cord blood donation. By seizing this opportunity, India

can embrace the potential of cord blood banking and


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International Journal of Medical Sciences And Clinical Research
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VOLUME

03

ISSUE

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P

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:

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SJIF

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MPACT

FACTOR

(2021:

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893

)

(2023:

6.

184

)

OCLC

1121105677















































Publisher:

Oscar Publishing Services

Servi

lead the way in advancing the field of regenerative

medicine, offering hope for a healthier and brighter

future for all.

REFERENCES

1.

Appelbaum FR. Pursuing the goal of a donor for

everyone in need. N Engl J Med. 2012; 367(16):1555-

1556.

2.

Chandra V, Arunava R, Devi D, Arun Kumar M,

Preeti K. Optimization of the Inventory size of the

Public cord blood program- The Indian context. The

Journal of the Association of Physicians of India.

2010; 58: 608-611

3.

Pitchappan RM, Kavitha, Jayalakshmi M. HLA

genomic diversity of India and its implications in

HIV pandemic. Intl J Hum Genet. 2008; 8: 143-153.

4.

Broxmeyer HE, Douglas GW, Hangoc G, Copper S,

Bard J et al. Human umbilical cord blood as a

potential source oftransplantable hematopoietic

stem/progenitor cells. Proc Natl Acad Sci. 1988;

86(10): 3828-3832.

5.

Eliane Gluckman, Broxmeyer Hal E, Arleen D,

Auerbach, Henry S et al. Hematopoietic

reconstitution in a patient with Fanconi’s anemia

by means of umbilical-cord blood from an HLA

identified sibling. N Engl J Med. 1989; 32(17): 1174-

1178.

6.

Ramnath Takiar, Deenu Nadayil, Nandakumar.

Projections of Number of Cancer Cases in India

(2010-2020) by Cancer Groups. Asian Pacific Journal

of Cancer Prevention. 2010; 11:1045-1049.

7.

Beatty PG, Boucher KM, Milford EL. Probability of

finding HLA-mismatched related or unrelated

marrow or cord blood donors. Human Immunology

2000; 61:834-40.

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Mckenna D, Sheth J. Umbilical cord blood: Current

status & promise for the future. Indian J Med Res

2011; 134:261-9.

References

Appelbaum FR. Pursuing the goal of a donor for everyone in need. N Engl J Med. 2012; 367(16):1555-1556.

Chandra V, Arunava R, Devi D, Arun Kumar M, Preeti K. Optimization of the Inventory size of the Public cord blood program- The Indian context. The Journal of the Association of Physicians of India. 2010; 58: 608-611

Pitchappan RM, Kavitha, Jayalakshmi M. HLA genomic diversity of India and its implications in HIV pandemic. Intl J Hum Genet. 2008; 8: 143-153.

Broxmeyer HE, Douglas GW, Hangoc G, Copper S, Bard J et al. Human umbilical cord blood as a potential source oftransplantable hematopoietic stem/progenitor cells. Proc Natl Acad Sci. 1988; 86(10): 3828-3832.

Eliane Gluckman, Broxmeyer Hal E, Arleen D, Auerbach, Henry S et al. Hematopoietic reconstitution in a patient with Fanconi’s anemia by means of umbilical-cord blood from an HLA identified sibling. N Engl J Med. 1989; 32(17): 1174-1178.

Ramnath Takiar, Deenu Nadayil, Nandakumar. Projections of Number of Cancer Cases in India (2010-2020) by Cancer Groups. Asian Pacific Journal of Cancer Prevention. 2010; 11:1045-1049.

Beatty PG, Boucher KM, Milford EL. Probability of finding HLA-mismatched related or unrelated marrow or cord blood donors. Human Immunology 2000; 61:834-40.

Mckenna D, Sheth J. Umbilical cord blood: Current status & promise for the future. Indian J Med Res 2011; 134:261-9.