Volume 03 Issue 07-2023
9
International Journal of Medical Sciences And Clinical Research
(ISSN
–
2771-2265)
VOLUME
03
ISSUE
07
P
AGES
:
09-12
SJIF
I
MPACT
FACTOR
(2021:
5.
694
)
(2022:
5.
893
)
(2023:
6.
184
)
OCLC
–
1121105677
Publisher:
Oscar Publishing Services
Servi
ABSTRACT
Ozone treatment is currently one of the topical issues. This article discusses treatment of epiduritis with ozone therapy
in traumatological patients, its modern methods.
KEYWORDS
Traumatic disease, surgical interventions, epiduritis, epidural hemorrhages, spinal canal.
INTRODUCTION
Relevance of the problem: In the near future, after a
fracture of the vertebrae, cicatricial changes often
occur in the spinal canal. This is primarily due to
hemorrhage into the spinal canal at the time of injury
and instability of the spine. The resulting cicatricial
adhesive processes lead to aggravation of the course
of traumatic disease of the spine and spinal cord,
deterioration of the neurological picture of the victim
(1,2,3). The existing various methods for preventing the
development of scarring, in particular, blowing air,
oxygen into the spinal canal, repeated surgical
interventions to remove scars, often do not give a
good effect, since excision of scar conglomerates does
not guarantee the formation of a repeated cicatricial
Research Article
THE USE OF OZONE IN THE TREATMENT OF EXPERIMENTAL TRAUMATIC
EPIDURITIS
Submission Date:
July 01, 2023,
Accepted Date:
July 05, 2023,
Published Date:
July 11, 2023
Crossref doi:
https://doi.org/10.37547/ijmscr/Volume03Issue07-03
A.B.Bolgaev
Termez Branch Of Tashkent Medical Academy, Uzbekistan
Ishburiev.N
Termez Branch Of Tashkent Medical Academy, Uzbekistan
Joynarov.Y.
Termez Branch Of Tashkent Medical Academy, Uzbekistan
Journal
Website:
https://theusajournals.
com/index.php/ijmscr
Copyright:
Original
content from this work
may be used under the
terms of the creative
commons
attributes
4.0 licence.
Volume 03 Issue 07-2023
10
International Journal of Medical Sciences And Clinical Research
(ISSN
–
2771-2265)
VOLUME
03
ISSUE
07
P
AGES
:
09-12
SJIF
I
MPACT
FACTOR
(2021:
5.
694
)
(2022:
5.
893
)
(2023:
6.
184
)
OCLC
–
1121105677
Publisher:
Oscar Publishing Services
Servi
process in the spinal canal, in particular the epidural
space ( 4.5).
MATERIAL AND METHOD
In vertebral-spiral injuries, the outflowing blood
transforms into a connective tissue scar within 3-4
weeks. To study this process, we conducted
experimental work on 45 rabbits in the Department of
Experimental Surgery of the Scientific Research
Institute of Health of the Uzbek SSR according to the
following method: hemilaminactomia was performed
from the posterior access on the arch of the 12th
thoracic or 1st lumbar vertebra, followed by the
introduction of 1 ml of the rabbit’s own b
lood into the
epidural space from the ear vein. Surgical induction of
trauma is widely used in the work of CITO and UzNIITO
employees. Two series of experiments were
performed.
1. The processes of formation of adhesions and scars in
the epidural space in intact animals (without the
introduction of ozone) on 15 rabbits were studied.
2. Study of the effects of ozone on the course of
adhesions and scars in the epidermal space when it is
introduced into the spinal canal in 30 rabbits. Ozone
was injected into the area of damage in the amount of
5-10 cm3 for 5-10-20-30 days after the injury, having
received it with the apparatus and methodology
developed by us. As an ozonizer, a Darsonval spark-
discharge high-frequency apparatus and an electrode
are used, which are enclosed in a glass cylinder.
Oxygen from the tank enters the latter through the
tubes, under the influence of high-frequency spark
discharges, the incoming oxygen is converted into
ozone (03), which is drawn into the syringe through
sterile tubes and the lumen of the tube located in the
spinal canal is directed.
To check the formation of ozone, I.A. Vetokhin
proposed iodine starch strip of filter paper, which turns
blue at a concentration of more than 1%. Work with
ozone in the presence of it up to 15% is considered safe
in this interval there is no explosive danger of gas.
Results and their discussion: In the control series of
experiments after fracture and resection of the
processes of the vertebral arch and injection of 1 ml of
blood into the epidural space during follow-up up to 10
days after injury, histological examination of
transverse sections of the vertebral column and spinal
cord on various hematomas in the epidural space and
the occurrence in the spinal membranes brain acute
circulatory disorders. Serous-proliferative epiduritis
with acute circulatory disorders occurs at individual
levels in the damaged area. In the area of damage to
the vertebral arch, a progressive periosteal and
endosteal reaction is noted with a pronounced
neoplasm of small bone trabeculae. In further periods
of observation up to 20-30 days, there is a complete
disappearance of traces of injected blood from the
epidural space. At the same time, an unevenly
Volume 03 Issue 07-2023
11
International Journal of Medical Sciences And Clinical Research
(ISSN
–
2771-2265)
VOLUME
03
ISSUE
07
P
AGES
:
09-12
SJIF
I
MPACT
FACTOR
(2021:
5.
694
)
(2022:
5.
893
)
(2023:
6.
184
)
OCLC
–
1121105677
Publisher:
Oscar Publishing Services
Servi
expressed proliferation of connective tissue and an
increase in the phenomenon of its fibrosis are noted.
Such scarring often leads, as a result of their tension,
to translocation of the spinal cord with the formation
of areas of cicatricial fusion of the dura mater with the
periosteum of the inner surface of the vertebrae and in
the lateral anterior and posterior parts of the spinal
canal. The data of these studies indicate that after an
injury to the spinal column, periodically repeated
epidural administration of ozone contributes to a
significant decrease in the severity of acute circulatory
disorders and reactive changes in epidural tissue, and
also reduces the severity of its subsequent fibrosis. As
a result, the severity of such consequences of fibrosis
as the occurrence of cicatricial translocation of the
spinal cord and secondary circulatory disorders
accompanied by a moderate manifestation of
congestion with the expansion of venous vessels and
the separation of erythrocyte mass from blood plasma
is significantly reduced. However, in contrast to the
control series of experiments, no fresh epidural
hemorrhages were observed. Judging by the more
uniform height of the epi and subdural space, there are
no leveled disorders of the blood and blood circulation.
In all cases of the experimental series in the area of
bone
tissue
damage,
the
preservation
of
hematopoietic bone marrow rich in cells is noted. In
the control series, by the end of 4 weeks, the scar
became more rough and formed. In the experimental
series of rabbits that underwent ozone insufflation
into the spinal canal, adhesion-cicatricial process was
not detected in the epidural space by the end of the
month. This once again confirms that ozone promotes
the destruction and resorption of adhesions and scars
in the epidural space of the spinal canal. Thus, in our
opinion, the positive effect of the introduction of
ozone is due to its physicochemical properties. When
introduced into the epidural space, it inflates it, as it
were, breaking the resulting adhesions between the
dura mater and the inner surface of the spinal canal of
rabbits. In addition, this unstable gas is an energetic
oxidizing agent; when introduced into the spinal canal,
it quickly splits into atomic active oxygen,
accompanied by the release of a certain amount of
energy. This energy contributes to the enhancement of
redox processes in the spinal canal, the resorption of
scar adhesions in it. The absence of adhesions of scars
in the epidural space leads to the normalization of
blood and liquor circulation in the spinal canal, the
improvement of the function of the spinal cord, the
disappearance or alignment of neurological changes
that occurred as a result of a spinal cord injury to the
spinal cord. Thus, ozone insufflation into the spinal
canal in case of a spinal injury in a rabbit contributes to
the prevention of adhesive and cicatricial processes in
the spinal canal and to the strengthening of the
regenerative functions of damaged bone tissues.
REFERENCES
Volume 03 Issue 07-2023
12
International Journal of Medical Sciences And Clinical Research
(ISSN
–
2771-2265)
VOLUME
03
ISSUE
07
P
AGES
:
09-12
SJIF
I
MPACT
FACTOR
(2021:
5.
694
)
(2022:
5.
893
)
(2023:
6.
184
)
OCLC
–
1121105677
Publisher:
Oscar Publishing Services
Servi
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