Volume 03 Issue 02-2023
54
International Journal of Medical Sciences And Clinical Research
(ISSN
–
2771-2265)
VOLUME
03
ISSUE
02
P
AGES
:
54-57
SJIF
I
MPACT
FACTOR
(2021:
5.
694
)
(2022:
5.
893
)
(2023:
6.
184
)
OCLC
–
1121105677
Publisher:
Oscar Publishing Services
Servi
ABSTRACT
The development of mucormycosis is also caused by the lack of timely diagnosis and treatment of patients with
chronic hemisinusitis after suffering from Covid-19, as well as the omission of intraocular and intracerebral
complications. Timely diagnosis and treatment of mucormycosis during a pandemic are of great importance in the
rapid recovery of the general condition of patients, and prevention of sinus thrombosis and other complications.
KEYWORDS
Mucormycosis, fungus, Loss of smell, Rhizopus, Lichtheimia Hemisinusitis.
INTRODUCTION
Antibacterial, hormone therapy, diuretics, antiviral
drugs,
anticoagulant,
antiaggregant,
hepatoprotectors, cardioprotectors, and symptomatic
treatments were carried out in the process of timely
Research Article
ANALYSIS OF EARLY DIAGNOSIS AND TREATMENT OF MUCORMYCOSIS
IN PATIENTS WITH COVID-19
Submission Date:
February 18, 2023,
Accepted Date:
February 23, 2023,
Published Date:
February 28, 2023
Crossref doi:
https://doi.org/10.37547/ijmscr/Volume03Issue02-11
Mirzaqandov Elyor Erkinjon Ogli
Assistant, Department Of Stomatology And Otorhinolaryngology, Fergana Public Health Medical Institute,
Fergana, Uzbekistan
Moydinov Ravshanjon Rakhimjonovich
Assistant, Department Of Stomatology And Otorhinolaryngology, Fergana Public Health Medical Institute,
Fergana, Uzbekistan
Usmonov Sanjar Bahromjon Ogli
Assistant, Department Of Stomatology And Otorhinolaryngology, Fergana Public Health Medical Institute,
Fergana, Uzbekistan
Journal
Website:
https://theusajournals.
com/index.php/ijmscr
Copyright:
Original
content from this work
may be used under the
terms of the creative
commons
attributes
4.0 licence.
Volume 03 Issue 02-2023
55
International Journal of Medical Sciences And Clinical Research
(ISSN
–
2771-2265)
VOLUME
03
ISSUE
02
P
AGES
:
54-57
SJIF
I
MPACT
FACTOR
(2021:
5.
694
)
(2022:
5.
893
)
(2023:
6.
184
)
OCLC
–
1121105677
Publisher:
Oscar Publishing Services
Servi
diagnosis and treatment of mucormycosis in patients,
rapid recovery of the general condition of patients,
prevention
of
sinus
thrombosis
and
other
complications.
Including Mucormycosis-black mould or black fungus
[1], an infection caused by the genera Mucor, Rhizopus,
and Rhizomucor of the Mucoreles family. The most
common symptoms of the disease are invasive necrotic
lesions in the nose and palate, causing pain, fever,
orbital cellulitis with proptosis, and purulent discharge
from the nose [2].
THE MAIN PART
Mucormycosis mainly starts in the mouth or nose and
spreads to the central nervous system by affecting the
eyes [2].
If this disease starts from the nose or paranasal sinuses
and passes to the brain, the signs and symptoms of the
disease are observed unilaterally. These are unilateral
eye pain, headache and facial pain, insomnia, fever,
loss of smell, and nasal and paranasal sinuses with
itching. symptoms such as congestion or flu are
considered.
Many
patients
develop
cholardagemysinusitis [3]. Swelling on one side of the
face, rapidly growing "black lesions" from the nose or
hard palate in the upper part of the mouth, one eye is
swollen and bulging, and vision may be blurred or
completely lost [1], [3].
Mucormycosis invasion of blood vessels can lead to
thrombosis and death of surrounding tissues due to
loss of blood supply [5].
Disseminated mucormycosis usually occurs in people
with other chronic conditions, so it can be difficult to
determine
which
symptoms
are
related
to
mucormycosis. As a clear example of these, patients
with diabetes can be seen. Looking back at history, the
first case of mucormycosis was described by Friedrich
Küchenmeister in 1855 [7].
Fürbringer first described the disease in the lungs in
1876[8]. In 1884, Lichtheim traced the development of
the disease in rabbits and described two types. "Mucor
corymbifera" and "Mucor rhizopodiformis", later
called "Lichtheimia" and "Rhizopus" [7].
In 1953, Saxenayea vasiform, which was found to cause
several cases, was isolated from forest soil in India, and
in 1979, PC Misra examined soil from an Indian mango
orchard, where Apophizomyces was isolated, later
identified as the major cause of mucormycosis [7].
Since then, several species of Mucorales have been
described [7]. In the mid-1950s, an American author
thought it was a new disease caused by the use of
antibiotics, ACTH, and steroids [8]. Until the second
half of the 20th century, the only treatment was
potassium iodide. In a review of pulmonary cases
diagnosed after flexible bronchoscopy between 1970
and 2000, survival was found to be better with surgery
and conservative treatment, mainly with amphotericin
B [8].
During the COVID-19 pandemic in Uzbekistan, this
disease has become another important health
problem. As of 2020-2021, 537 patients with diseases of
the nose and paranasal sinuses were treated in the
Otorhinolaryngology Department of the Regional
Multidisciplinary Medical Center in the Fergana region.
More than 50 patients were treated with
mucormycosis. The risk of developing this type of
disease is highest in coronavirus patients who have
diabetes or are immunocompromised. Late detection
of this infection in humans is fatal. For this reason,
doctors advised patients with coronavirus to take
"black mould" seriously and consult a doctor when
symptoms are observed [12].
Volume 03 Issue 02-2023
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International Journal of Medical Sciences And Clinical Research
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03
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P
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54-57
SJIF
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(2021:
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(2022:
5.
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)
(2023:
6.
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OCLC
–
1121105677
Publisher:
Oscar Publishing Services
Servi
Many media outlets have referred to it as black fungus,
which is caused by a fungus found in dead and dying
tissue.
Even before the COVID-19 pandemic, the incidence of
mucormycosis was observed worldwide and was
approximately 70 times higher in India compared to
other mucormycosis-endemic countries [9].
Due to the rapid increase in the number of cases, many
states and governments of India have declared the
mucormycosis
epidemic[10].
Several
cases
of
mucormycosis, aspergillosis and candidiasis were
reported to be associated with immunosuppressive
treatment for COVID-19 during the 2020/21 pandemic in
India [11].
In early 2021, one review of the association between
mucormycosis and COVID-19 reported eight cases of
mucormycosis. In particular, three were from the USA,
two from India, Brazil, and Italy and one from the UK.
CONCLUSION
Early diagnosis and treatment of hemisinusitis in
patients with Covid-19 will help prevent complications
of the disease such as mucormycosis and sinus
thrombosis among patients.
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Soutik Biswas. “Mucormycosis: The 'black
fungus' maiming Covid patients in India”. BBC.
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Volume 03 Issue 02-2023
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International Journal of Medical Sciences And Clinical Research
(ISSN
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03
ISSUE
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P
AGES
:
54-57
SJIF
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FACTOR
(2021:
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)
(2022:
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893
)
(2023:
6.
184
)
OCLC
–
1121105677
Publisher:
Oscar Publishing Services
Servi
enterprises in the origin of respiratory tract
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