Volume 02 Issue 08-2022
5
International Journal of Medical Sciences And Clinical Research
(ISSN
–
2771-2265)
VOLUME
02
I
SSUE
08
Pages:
05-07
SJIF
I
MPACT
FACTOR
(2021:
5.
694
)
(2022:
5.
893
)
OCLC
–
1121105677
METADATA
IF
–
5.654
Publisher:
Oscar Publishing Services
Servi
ABSTRACT
Glaucoma is “a chronic progressive optic neuropathy that combines a group of diseases with characteristic
morphological changes in the optic nerve head (excavation) and retinal nerve fiber layer in the absence of other
ophthalmic pathology” (European Glaucoma Society Terminology and Guidelines for Glaucoma 2017) (1,2).
KEYWORDS
Medical, laser and surgical methods, Statistical processing, morphological changes.
INTRODUCTION
Aim of the study: To evaluate the effectiveness of
endonasal electrophoresis in the complex therapy of
glaucomatous optic neuropathy based on the
dynamics of hemodynamic parameters.
Research Article
COMPARATIVE ANALYSIS OF HEMODYNAMIC PARAMETERS AGAINST
THE BACKGROUND OF COMPLEX TREATMENT OF GLAUCOMATOUS
OPTIC NEUROPATHY BY ENDONASAL ELECTROPHORESIS
Submission Date:
August 15, 2022,
Accepted Date:
August 25, 2022,
Published Date:
August 30, 2022
Crossref doi:
https://doi.org/10.37547/ijmscr/Volume02Issue08-02
N.R. Yangieva
Tashkent State Dental Institute, Uzbekistan
T.T. Saidov
Samarkand State Medical Institute, Uzbekistan
U.B. Khamidov
Bashkir State Medical Institute, Uzbekistan
Journal
Website:
https://theusajournals.
com/index.php/ijmscr
Copyright:
Original
content from this work
may be used under the
terms of the creative
commons
attributes
4.0 licence.
Volume 02 Issue 08-2022
6
International Journal of Medical Sciences And Clinical Research
(ISSN
–
2771-2265)
VOLUME
02
I
SSUE
08
Pages:
05-07
SJIF
I
MPACT
FACTOR
(2021:
5.
694
)
(2022:
5.
893
)
OCLC
–
1121105677
METADATA
IF
–
5.654
Publisher:
Oscar Publishing Services
Servi
MATERIALS AND RESEARCH METHODS
Under clinical observation there were 80 (116 eyes)
patients with glaucomatous optic neuropathy (GON)
aged 40 to 78 years, of which 44 (55%) were women, 36
(45%) were men, with an established diagnosis of POAG
and PACG II or Stage III under conditions of IOP
compensation (21.3±3.2). IOP compensation was
achieved by medical, laser and surgical methods.
Depending on the treatment, the following
representative groups were identified: control, I main
and II main. The control, which included 20 patients, of
which the number of men 12 (15%), and women 8 (10%),
Patients in this group received conventional therapy. I
main, which includes 30 patients, the number of men
was 16 (20%), the number of women was also 14 (17.5%).
The patients of this group, in addition to traditional
therapy and Sol Retinalamini -2 ml No. 10, received Sol.
Tanacani - 1 ml by endonasal electrophoresis on a
galvanization apparatus Flow 1. II main, which includes
30 patients, the number of men was 16 (20%), the
number of women was also 14 (17.5%). Patients in
addition to traditional therapy and Sol Retinalamini -2
ml No. 10, endonasal electrophoresis, Statistical
processing of the obtained data was carried out on a
personal computer using the program “Statistica 8.0”.
The study was conducted with the informed consent of
the observed patients.
RESULTS AND DISCUSSIONS
A decrease in the initial values of hemodynamic
parameters occurred in all examined patients, which
was confirmed by ultrasound Doppler mapping of the
CAS and SCCA. Thus, the initial values of Vmax and
Vmin CAS in all the studied groups were within 11.5 and
4.5 cm/s, and the resistance index varied from 0.63 to
0.66. On the 10th day after the treatment in all groups,
positive dynamics were noted in varying degrees of
severity, for example, in the control group, Vmax
increased to 14.73, and Vmin to 5.54, which was almost
1.3 times higher than the initial values, and the index
resistance decreased from 0.63 to 0.62, however, by
the 6th month of observation, all indicators almost did
not differ from the initial ones. The initial indicators of
SCCA in the control group did not differ much from
those of the CAS, and in dynamics there was a
tendency to decrease in RI by 0.01 and amounted to
0.64. In the main group I, there was a significant
improvement in the hemodynamic parameters of both
the CAS and the SCCA, especially the maximum systolic
blood flow velocity, which was maximum already on
the 10th day of the examination 19.58 cm/s in the CAS
(p≤ 0.01) and 18.90 cm/s c in SCCA (p≤ 0.05), which
undoubtedly confirms the improvement in blood
supply due to the drug “Tanakan”, however, starting
from the 3rd month, these indicators tended to slightly
decrease, and by the 6th month, these indicators
almost did not differ from the baseline. It should be
noted that a marked decrease in the resistance index
was observed more in SCCA than in CAS from 0.66 to
0.57. In the II main group, almost identical significant
dynamics was observed, followed by a decrease by the
6th month, however, a decrease in the resistance index
in the CAS was observed more significantly than in the
I main group.
The VEP indicators during treatment in all three groups
differed in amplitude and latency, so in the control and
main group I, these indicators in dynamics did not
differ much from the baseline indicators and had low
statistical significance, while significant differences
were observed already on the 10th day of observation
during the second main group, which amounted to 10.1
μV, and the duration of the nerve impulse was reduced
by 88.9 ms (p≤ 0.05) and which was associated with a
positive effect after receiving transcutaneous
electrical stimulation.
Volume 02 Issue 08-2022
7
International Journal of Medical Sciences And Clinical Research
(ISSN
–
2771-2265)
VOLUME
02
I
SSUE
08
Pages:
05-07
SJIF
I
MPACT
FACTOR
(2021:
5.
694
)
(2022:
5.
893
)
OCLC
–
1121105677
METADATA
IF
–
5.654
Publisher:
Oscar Publishing Services
Servi
CONCLUSIONS
The use of endonasal electrophoresis with the drug
“Tanakan” in combination with transcutaneous
electrical stimulation in the complex treatment of GON
significantly (p≤ 0.01) improves hemodynamic
parameters according to Doppler ultrasound data.
REFERENCES
1.
Flammer D. Glaucoma // Glaucoma. World;
WidePrinting, 2003. ―p. 345.
2.
Kurysheva N.I. Glaucoma optic neuropathy.
Moscow: MEDpress-inform, 2006. –p 136 p.
