СОВРЕМЕННЫЕ АСПЕКТЫ ОБЕСПЕЧЕНИЯ ЭФФЕКТИВНОЙ И БЕЗОПАСНОЙ ФАРМАКОТЕРАПИИ

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Эшонхужаев O., & Хасанова , Ш. (2022). СОВРЕМЕННЫЕ АСПЕКТЫ ОБЕСПЕЧЕНИЯ ЭФФЕКТИВНОЙ И БЕЗОПАСНОЙ ФАРМАКОТЕРАПИИ. Медицинская наука Узбекистана, (1), 08–10. извлечено от https://inlibrary.uz/index.php/medical_scienceuz/article/view/8627
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Аннотация

Фармакотерапия являясь самым основным методом консервативного лечения, на сегодняшний день, одна из направлений достигших пика своего развития. По последним данным, в настоящее время на мировом фармакологическом рынке в обороте имеется около 30000 (!) наименований лекарственных препаратов. В связи с этим перед практикующим врачом стоит такая актуальная задача как не только запоминание вышеупомянутых лекарственных средств, но и их рациональное использование в ежедневной практике. По оценке экспертов ВОЗ, более половины всех лекарственных средств неправильно назначаются, отпускаются или продаются, а половина всех пациентов, получающих лекарственные средства, неправильно принимают их. Чрезмерное, недостаточное или неправильное использование лекарств приводит к расточительному расходованию ограниченных ресурсов и возникновению широко распространенных угроз для здоровья.


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MODERN ASPECTS OF PROVIDING EFFECTIVE AND SAFE

PHARMACOTHERAPY

Eshonkhujaev O.O.

1

, Khasanova Sh.J.

1

Andijan State Medical Institute, Andijan, Uzbekistan

Annotation:

The rapid development of pharmaceutical chemistry, pharmacology and the pharmaceutical industry

in recent years has led to an unprecedented expansion and growth of the pharmaceutical market. According to the latest

data, today about 30000 (!) names of medicines are converted on the world pharmacological market. Therefore, the

practitioner has an urgent task not only to remember the names of the above drugs, but also to use them correctly in

everyday activities. In addition, the doctor will need to know the advantages and disadvantages of new drugs compared

to old ones, the interaction of drugs in the div. The effective, safe use of drugs can be studied by a physician as a result

of many years of experience and skilled practice. The WHO estimates that more than half of all medicines are misused,

dispensed or sold, and half of all patients receiving medicines are taking them incorrectly. Over-use, under-use or misuse

of drugs is wasting limited resources and widespread health threats.

Relevance of the topic.

Pharmacotherapy

is one of the main methods of conservative

treatment and is one of the most advanced

areas of clinical medicine today in terms of

development [1]. «Pharmacotherapy» is the

treatment of any type of disease or patient with

drugs, which, in the traditional sense, is one of

the main methods of conservative treatment.

Historically, mankind has had empirical

knowledge since ancient times about the

medicinal and toxic effects of various products

derived from plants and animals. Even before

our era, there were attempts to introduce

effective methods of treatment into medicine, but

misconceptions about the origin of the disease at

that time led to the ineffectiveness of its treatment

and monitoring [1,3].

Introduction.

In the following years

he developed pharmaceutical chemistry,

pharmacology and pharmaceutical industry

medication sunprecedented expansion of the

market and called According to the latest data,

today in the world pharmacological market there

are about 30000 (!) names of drugs [3,4,5].

Therefore practitioner above medication in

front of a doctor name remember not only to

receiver their daily activities use settings keep

up to date in. In addition, doctor the advantages

and disadvantages of new drugs over old ones,

preparation in the div own interactions know

both need will be [2]. WHO experts note that

more than half of medicines are incorrectly

Key words:

drug container, drugs, pharmacotherapy, pharmaceutical market, patients, skilled practice.

Article

www.fdoctors.uz

published: 30 July 2022

2022 / Issue 01 / Article 02

8

Medical science of Uzbekistan

recommended, distributed, sold or not properly

received by patients. The use of drugs in excess,

incorrectly or insufficiently leads not only to an

increase in costs, but also to the ineffectiveness

of on going pharmacotherapy, along with a direct

greater risk to human health [3,6].

Deffective, safe use of bees doctor many

years of experienceand qualifying practiceas a

result can learn. However, is the pharmacotherapy

performed by that treating physician always

effective and safe? There is a second very

important aspect of the issue, without which the

ultimate goal cannot be achieved. That is, the

importance of how patients take the medications

recommended by their physicians is no less

important than the above [7].

Ingestion of drugs leads to a sharp change in

the pharmacocynetic parameters of drugs, which

becomes one of the main factors directly affecting

the pharmacodynamics of drugs, changes in

potency and quality of pharmacotherapy. As a

result, pharmacotherapy is not only ineffective and

even in some cases, can lead to life-threatening

complications in the patient [3,8,9,10].

The purpose of the study.

Improving the

effectiveness and safety of pharmacotherapy by

achieving timely and accurate patient acceptance

of medications recommended by physicians

using a multi-cabin counter medication box.

Materials and methods.

The authors

studied this topical issue by conducting

retrospective surveys among treating physicians

Received:

17 july 2022

Accepted:

24 july 2022

Published:

30 july 2022

doi.org/10.56121/2181-3612-2022-1-08-10


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published: 30 July 2022

Medical science of Uzbekistan

www.fdoctors.uz

2022 / Issue 01 / Article 02

9

and patients in several hospitals in order to find a

positive solution.

In this case, doctors ask about their

specialization, whether there are patients taking

regular medications, how many times a day, how

many and how many different drugs they take,

and the side effects of taking medications on

time or not taking them on time. it was concluded

by asking physicians questions about how to

regulate the timely administration of medications

to their patients.

Patients were asked about their age,

what disease they were suffering from, how long

they had been ill, how long they had been taking

medication (year, month, week, day), how many

times a day, how many and how many different

medications they had taken, and how long they

had been on time. how to regulate, what is the

effect of timely medication, whether there are any

adverse effects such as recurrence, exacerbation

or complications as a result of untimely medication,

and finally information about other patients who

recovered quickly due to timely medication were

asked questions about their possessions.

Results and discussion.

In the course of

studying the problem, responses were received

that the treating physicians should give patients a

100% clear understanding of the medication they

should take and prescribe them the time to take

it. However, it was also pointed out that they do

not guarantee that they will drink exactly that way.

The study found that treating physicians provide

their patients with a clear understanding of the

medication they need to take on a regular basis.

According to the results of the survey - 92% of

patients received a response that they are aware

of the benefits of taking medications in a timely

manner. However, 69% of them admitted that

they did not take the medication on time. Only

25% of respondents admitted that they take

medicines recommended by a doctor, strictly as

prescribed. 6% of patients paid attention only to

the fact of taking medicine regardless of doctor’s

recommendations.

According to the world medical statistics

of this field, in the United States of America, in

studies conducted by WHO experts (Bertram

G. Katsung, Lawrence, G. Duques), in the early

2000s, in the field of clinical pharmacology, in

900,000 cases, various errors were made when

taking drugs by patients within 1 year, and there

have been 200,000 deaths due to these errors...

When the problem was studied, it was found

that the above condition is mainly related to the

patient’s personal qualities, which are primarily

caused by factors such as lack of understanding

of the essence of the problem, inattention,

inability to concentrate, as well as decreased

vision, hearing and memory.

For this reason, it is necessary to ensure

that patients receive their medications on time,

which should be considered as the main criterion

for increasing the effectiveness and safety of

pharmacotherapy.

Various measures have been taken at

the state level to address this issue: improving

the medical culture of patients, strength control

over the reception of drugs by medical staff, and

others. However, so far these measures have not

yielded results.

Conclusion.

By incorporating multi-

cabin innovative timer box activity into the


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published: 30 July 2022

Medical science of Uzbekistan

www.fdoctors.uz

2022 / Issue 01 / Article 02

10

pharmacotherapy process, patients are able

to receive the recommended medications in a

timely and accurate manner. This will increase

the effectiveness and safety of pharmacotherapy

and lead to cost savings.

Literature.

1. Sheiner LB. The intellectual health of

clinical drug evaluation. Clin. Pharmacol. Ther. -

1991-; 50: 4–9.

2. Thummel KE, Shen DD. Design

and optimization of dosage regimens:

Pharmacokinetic data.In: Hardman JG, Limbird

LE, Gilman AG, eds. Goodman & Gilman’s The

pharmacological basis of therapeutics. 10th ed.

New York: Mc Graw-Hill;-2001.-p. 1924–2023.

3. Eshonxo’jaev O.O. Kurbanova D.I.,

Ziyaeva D.F. Timer medicine box - an innovative

innovation in the process of pharmacotherapy //

Scientific-methodical journal «UZ Academia» -

2020. - №1, Part 3 - 304 p.

4. Rational use of medicines. Educational

and methodological recommendation of the

Health project. // «UBI Consulting» in cooperation

with «Edburgh Consultants»-2008.-17-35 p.

5. Guidelines for the rational use of

medicines. // Under the editorship of Academician

Chuchalin A.G., Belousov Yu.B., Khabriev R.U.,

Ziganshina L.E.-M .: GEOTAR-Media-2006.-

5-34 s.

6. Vekov T.Y. Rational pharmacotherapy,

based on the results of pharmacoeconomic audit:

principles and application in Bulgaria // Rational

pharmacotherapy in cardiology – 2014 - ;10(4):

402-405.

https://doi.org/10.20996/1819-6446-

2014-10-4-402-405

7. Reidenberg MM Clinical pharmacology:

The scienti fi c basis of therapeutics. Clin

Pharmacol Ther-1999-; 66: 2–8

8. Atkinson AJ Jr, Nordstrom K. The

challenge of in-hospital medication use: An

opportunity for clinical pharmacology. Clin

Pharmacol Ther-1996-; 60: 363–7.

9. Bertram G. Katzung R. Basic & Clinical

Pharmacology // Prentice-Hall International Inc.

University of California-2011.-1590 p.

10. Clinical pharmacology. Edited by

V.G. Kukes, A.K. Starodubtsev // Textbook. M.:

GEOTAR-Media - 2012 - 832 p.

Библиографические ссылки

Sheiner LB. The intellectual health of clinical drug evaluation. Clin. Pharmacol. Ther. - 1991-; 50: 4–9.

Thummel KE, Shen DD. Design and optimization of dosage regimens: Pharmacokinetic data.In: Hardman JG, Limbird LE, Gilman AG, eds. Goodman & Gilman's The pharmacological basis of therapeutics. 10th ed. New York: Mc Graw-Hill;-2001.-p. 1924–2023.

Eshonxo'jaev O.O. Kurbanova D.I., Ziyaeva D.F. Timer medicine box - an innovative innovation in the process of pharmacotherapy // Scientific-methodical journal "UZ Academia" - 2020. - №1, Part 3 - 304 p.

Rational use of medicines. Educational and methodological recommendation of the Health project. // "UBI Consulting" in cooperation with "Edburgh Consultants"-2008.-17-35 p.

Guidelines for the rational use of medicines. // Under the editorship of Academician Chuchalin A.G., Belousov Yu.B., Khabriev R.U., Ziganshina L.E.-M .: GEOTAR-Media-2006.- 5-34 s.

Vekov T.Y. Rational pharmacotherapy, based on the results of pharmacoeconomic audit: principles and application in Bulgaria // Rational pharmacotherapy in cardiology – 2014 - ;10(4): 402-405 Https://doi.org/10.20996/1819-6446-2014-10-4-402-405

Reidenberg MM Clinical pharmacology: The scienti fi c basis of therapeutics. Clin Pharmacol Ther-1999-; 66: 2–8

Atkinson AJ Jr, Nordstrom K. The challenge of in-hospital medication use: An opportunity for clinical pharmacology. Clin Pharmacol Ther-1996-; 60: 363–7.

Bertram G. Katzung R. Basic & Clinical Pharmacology // Prentice-Hall International Inc. University of California-2011.-1590 p.

Clinical pharmacology. Edited by V.G. Kukes, A.K. Starodubtsev // Textbook. M.: GEOTAR-Media - 2012 - 832 p.

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